BGC0000137: rifamycin biosynthetic gene cluster from Salinispora arenicola CNS-205
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Location: 1,375,747 - 1,480,342 nt. (total: 104,596 nt).
This entry is originally from NCBI GenBank CP000850.1.

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Biosynthesis
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NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0000137
Short description | rifamycin biosynthetic gene cluster from Salinispora arenicola CNS-205
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Unknown)

Loci
CP000850.1
1388770 - 1480342
via
Compounds

- rifamycin

Species Salinispora arenicola CNS-205 [taxonomy]
References

- [1] Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction. Kim TK et al., Appl Environ Microbiol (2006) PMID:16517661
- [2] Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450. Wilson MC et al., J Am Chem Soc (2010) PMID:20726561
- [3] LC-MS-based metabolomics study of marine bacterial secondary metabolite and antibiotic production in Salinispora arenicola. Bose U et al., Mar Drugs (2015) PMID:25574739

Chemical products information
rifamycin Evidence:
Copy SMILES
C37H47N1O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
Sare_1240 ABV97145.1 | 1388770 - 1389078 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
Sare_1241 ABV97146.1 | 1389748 - 1391679 (+) | multicopper oxidase type 2 |  |  | copy AA seq copy Nt seq
Sare_1242 ABV97147.1 | 1392183 - 1393169 (+) | oxidoreductase domain protein |  |  | copy AA seq copy Nt seq
Sare_1243 ABV97148.1 | 1393166 - 1394122 (+) | oxidoreductase domain protein |  |  | copy AA seq copy Nt seq
Sare_1244 ABV97149.1 | 1394176 - 1394472 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
Sare_1245 ABV97150.1 | 1394515 - 1395708 (+) | cytochrome P450 |  |  | copy AA seq copy Nt seq
Sare_1246 ABV97151.1 | 1395747 - 1411211 (+) | AMP-dependent synthetase and ligase |  |  | copy AA seq copy Nt seq
Sare_1247 ABV97152.1 | 1411245 - 1427012 (+) | Beta-ketoacyl synthase |  |  | copy AA seq copy Nt seq
Sare_1248 ABV97153.1 | 1427057 - 1432552 (+) | Beta-ketoacyl synthase |  |  | copy AA seq copy Nt seq
Sare_1249 ABV97154.1 | 1432589 - 1437958 (+) | Beta-ketoacyl synthase |  |  | copy AA seq copy Nt seq
Sare_1250 ABV97155.1 | 1438010 - 1448494 (+) | Acyl transferase |  |  | copy AA seq copy Nt seq
Sare_1251 ABV97156.1 | 1448509 - 1449285 (+) | N-acetyltransferase |  |  | copy AA seq copy Nt seq
Sare_1252 ABV97157.1 | 1449319 - 1449489 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
Sare_1253 ABV97158.1 | 1449486 - 1450547 (+) | 3-dehydroquinate synthase |  |  | copy AA seq copy Nt seq
Sare_1254 ABV97159.1 | 1450544 - 1451884 (+) | 3-deoxy-7-phosphoheptulonate synthase |  |  | copy AA seq copy Nt seq
Sare_1255 ABV97160.1 | 1452288 - 1453454 (+) | Glutamine--scyllo-inositol transaminase |  |  | copy AA seq copy Nt seq
Sare_1256 ABV97161.1 | 1453451 - 1454524 (+) | oxidoreductase domain protein |  |  | copy AA seq copy Nt seq
Sare_1257 ABV97162.1 | 1454537 - 1455223 (+) | AHBA synthesis associated protein |  |  | copy AA seq copy Nt seq
Sare_1258 ABV97163.1 | 1455403 - 1455762 (-) | Rieske (2Fe-2S) domain protein |  |  | copy AA seq copy Nt seq
Sare_1259 ABV97164.1 | 1456076 - 1457344 (-) | cytochrome P450 |  |  | copy AA seq copy Nt seq
Sare_1260 ABV97165.1 | 1457669 - 1458934 (+) | cytochrome P450 |  |  | copy AA seq copy Nt seq
Sare_1261 ABV97166.1 | 1458931 - 1459125 (+) | protein of unknown function DUF1271 |  |  | copy AA seq copy Nt seq
Sare_1262 ABV97167.1 | 1459355 - 1460596 (-) | conserved polyketide synthase associated protein PapA5 |  |  | copy AA seq copy Nt seq
Sare_1263 ABV97168.1 | 1460901 - 1462064 (-) | protein of unknown function DUF1205 |  |  | copy AA seq copy Nt seq
Sare_1264 ABV97169.1 | 1462393 - 1463700 (+) | DegT/DnrJ/EryC1/StrS aminotransferase |  |  | copy AA seq copy Nt seq
Sare_1265 ABV97170.1 | 1463931 - 1465280 (-) | aminotransferase class-III |  |  | copy AA seq copy Nt seq
Sare_1266 ABV97171.1 | 1465454 - 1466464 (-) | oxidoreductase domain protein |  |  | copy AA seq copy Nt seq
Sare_1267 ABV97172.1 | 1467067 - 1468509 (+) | NDP-hexose 23-dehydratase |  |  | copy AA seq copy Nt seq
Sare_1268 ABV97173.1 | 1468568 - 1470160 (-) | monooxygenase FAD-binding |  |  | copy AA seq copy Nt seq
Sare_1269 ABV97174.1 | 1470157 - 1470927 (-) | Oleoyl-(acyl-carrier-protein) hydrolase |  |  | copy AA seq copy Nt seq
Sare_1270 ABV97175.1 | 1471788 - 1473053 (+) | transcriptional regulator, LuxR family |  |  | copy AA seq copy Nt seq
Sare_1271 ABV97176.1 | 1473050 - 1473874 (+) | Methyltransferase type 11 |  |  | copy AA seq copy Nt seq
Sare_1272 ABV97177.1 | 1473979 - 1474716 (+) | Transketolase domain protein |  |  | copy AA seq copy Nt seq
Sare_1273 ABV97178.1 | 1474713 - 1475624 (+) | Transketolase central region |  |  | copy AA seq copy Nt seq
Sare_1274 ABV97179.1 | 1475748 - 1476560 (-) | Shikimate dehydrogenase substrate binding domain protein |  |  | copy AA seq copy Nt seq
Sare_1275 ABV97180.1 | 1476676 - 1477614 (-) | ROK family protein |  |  | copy AA seq copy Nt seq
Sare_1276 ABV97181.1 | 1477624 - 1477977 (-) | DoxX family protein |  |  | copy AA seq copy Nt seq
Sare_1277 ABV97182.1 | 1478072 - 1478503 (-) | 3-dehydroquinate dehydratase |  |  | copy AA seq copy Nt seq
Sare_1278 ABV97183.1 | 1478771 - 1480342 (-) | FAD dependent oxidoreductase |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2019-10-16
Updated reference publication(s) (MIBiG Annotathon)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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