LOCUS       BGC0000140             15000 bp    DNA     linear   BCT 09-DEC-2009
DEFINITION  Streptomyces sp. 88-682 putative dipeptidyl aminopeptidase gene,
            complete cds; tetronate RK-682 biosynthetic gene cluster, complete
            sequence; and putative beta-lactamase domain-containing protein
            gene, complete cds.
ACCESSION   BGC0000140
VERSION     BGC0000140
KEYWORDS    .
SOURCE      Streptomyces sp. 88-682
  ORGANISM  Streptomyces sp. 88-682
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 12:58:15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15000
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..15000
                     /country="Japan: Kuroishi City, Aomori"
                     /db_xref="taxon:697274"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. 88-682"
                     /strain="88-682"
     subregion       1..15000
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15000
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(113..1258)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf1"
                     /product="putative dipeptidyl aminopeptidase"
                     /protein_id="ACZ65471.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-08, bitscore: 24.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.7e-11, bitscore:
                     34.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLFDDPAFDYQALRAAGYADFGGAQLGEIIAVASRIPGGDTDA
                     WRREWTALAERVHGLATAALAQHRTLDARAALLRAHTYYRTAEFFLRDDPLHDPEAARL
                     MRLSKETFAEAAGLMERPPEFVRIPYGDGSLPGYFYRADDSAGPRPTLIHHGGIDSTLE
                     EGYFFIAAAAQARGYHVLCFEGPGQGSVLREQGLTFRPDWEEVVTPVVDFALARPGVDP
                     ERVTLVGTSLGGLLAVRAAAFEHRLAGCVAHDAVWQLGDVVWLPPFVHEWVEQGCDDFA
                     NPVMYGIAVQQTFRAGCCGRRCGRSGRRAPPNCCAGCPRSASRTWSGRCAVRSWCSTPR
                     RTCSSPVWNTRRRCTRAWAAPRPCTCSPRTRAGEPTATPAP"
     gene            complement(1382..2071)
                     /gene="rkI"
     CDS             complement(1382..2071)
                     /codon_start=1
                     /gene="rkI"
                     /gene_functions="regulatory (smcogs) SMCOG1224:TetR family
                     transcriptional regulator (Score: 148.3; E-value: 3.9e-45)"
                     /gene_kind="regulatory"
                     /note="RkI"
                     /product="TetR transcriptional regulator"
                     /protein_id="ACZ65472.1"
                     /transl_table=11
                     /translation="MPPPVPPEAEGAAPTGLRPVPATGDGHAPAQRTARGGRQRDPAAD
                     RAILESTLGLLGEGCSFSALSMDLVAQRAGVARATIYRRWRNKEELVLAALSSLDVPVT
                     PSDGLPLRERLVDLVDQIRHRGQDTHLHRLLAGLLGEAVHRPQLVEAYENTAVAARRDA
                     MRQVLRDGLDSGELRPGLDVDQAIELLTGPMLARLILRQRPVESAAFAEAIVDTFLDGT
                     RSNPAPR"
     misc_feature    1382..13187
                     /note="tetronate RK-682 biosynthetic gene cluster"
     gene            complement(2074..3669)
                     /gene="rkH"
     CDS             complement(2074..3669)
                     /codon_start=1
                     /gene="rkH"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 390.4; E-value:
                     1.4e-118)"
                     /gene_kind="transport"
                     /note="RkH"
                     /product="antibiotic efflux protein"
                     /protein_id="ACZ65473.1"
                     /transl_table=11
                     /translation="MTTQLEPRKTEQDQAAAHRWWVLGVLVVSLLLVVLDTSILNVALK
                     TLAEPAPQGLGASSSALQWSVDSYTLVFAALLFSTGVLADRWGRKRTLVTGLVVFGGCS
                     LWSAYAGSAGELIAARAGLGVGGALVMPATLAIIMNVFPPAEHAKAVGIWAGAAGLAVA
                     VGPITGGALLEHFWWGSVFLINIPIVVIGTVAALVVVPESRDPGRGGFDPVGVALSVAG
                     LTLLVYGVIQGGESDDWAAGRVWGTMLGGLVVLAVFVGWERRAERPALDIALFRVPRFS
                     AAVTVIGLVFFALLGATFFLVFYLQSVRGWTPLQAGYCLLPLAVAQLAFSPPATLAAKR
                     IGVRPVCTTGMLLTTLAFVTVATVDEHTSLWLLESVFFVLGVGIACVMPPATAAVMSAL
                     PRQRAGTGSAVNTTFRQVGGALGVAVLGSVLSTAYRSRMSDHLGAVPDQLRDKAGESVQ
                     SSLAAADALGPRGASLAGHAVDSFVSAMHVTALVAAGVTFLGTLVSLLLLPARTPDEGA
                     GAPEAARVHHSSEV"
     gene            4025..5821
                     /gene="rkA"
     CDS             4025..5821
                     /NRPS_PKS="Domain: CAL_domain (37-472). E-value: 4.1e-112.
                     Score: 366.9. Matches aSDomain:
                     nrpspksdomains_rkA_CAL_domain.1"
                     /codon_start=1
                     /gene="rkA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     404.6; E-value: 8.1e-123)"
                     /gene_kind="biosynthetic-additional"
                     /note="RkA"
                     /product="palmitoyl-CoA synthetase"
                     /protein_id="ACZ65474.1"
                     /sec_met_domain="AMP-binding (E-value: 7.5e-91, bitscore:
                     294.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHQTLTEAVRAGAEQHPDRLAFVYLHEDGRTMRPEELTYAELDRR
                     ARLIATRLRQESLGDPSRPVLLLYPPTLDFVTAFLGCFYAGRTAIPAPLPDEPGERLAR
                     VSGILRDASVGAVLTLPEHRQGLAAWLAASGEQDVVCLAPEDDGEDPALWFPPQVRADD
                     IAFLQYSSGSTSQPKGVMVTHANLAANQEAIHHAMLTTPGVVTGSWLPLYHDMGLIGMT
                     LHPLWMGGTSVQMSPISFIKQPHRWLRMIHDYRVEGTASPDFGYELCARRTTDEQAEGL
                     DLSSLRVALNGAEPVRAATIRTFTARFAAQGLRPEALFPCYGLAENTLLASAGDTTAPH
                     VELAVDAHLLEQHELRPARPDRTSRTLVGCGTPAGSEVLIVDPMTCQALADGQVGEIWL
                     RGPSVARGYWNRPEATDETFRAETADGRNGYLRTGDLGGLVGGELFVTGRIKEMLIHHG
                     RNLYPQDIEQAVQDSGPALRRGGGAVFTVGDEEGERSHVVVVQEVRPNQQGEHDLPALA
                     ASVQTVLSRRFQLPAASVVLVRPGAIRKTTSGKTQRTLMRRLFLDGALSVLHQRLERPV
                     AELVARPAETPEHSAPLAAPGR"
     aSDomain        4136..5440
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rkA_CAL_domain.1"
                     /evalue="4.10E-112"
                     /label="rkA_CAL_domain.1"
                     /locus_tag="rkA"
                     /protein_end="472"
                     /protein_start="37"
                     /score="366.9"
                     /tool="antismash"
                     /translation="TYAELDRRARLIATRLRQESLGDPSRPVLLLYPPTLDFVTAFLGC
                     FYAGRTAIPAPLPDEPGERLARVSGILRDASVGAVLTLPEHRQGLAAWLAASGEQDVVC
                     LAPEDDGEDPALWFPPQVRADDIAFLQYSSGSTSQPKGVMVTHANLAANQEAIHHAMLT
                     TPGVVTGSWLPLYHDMGLIGMTLHPLWMGGTSVQMSPISFIKQPHRWLRMIHDYRVEGT
                     ASPDFGYELCARRTTDEQAEGLDLSSLRVALNGAEPVRAATIRTFTARFAAQGLRPEAL
                     FPCYGLAENTLLASAGDTTAPHVELAVDAHLLEQHELRPARPDRTSRTLVGCGTPAGSE
                     VLIVDPMTCQALADGQVGEIWLRGPSVARGYWNRPEATDETFRAETADGRNGYLRTGDL
                     GGLVGGELFVTGRIKEMLIHHGRNLYPQDIEQAVQD"
     CDS_motif       4517..4576
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkA_0001"
                     /evalue="1.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="rkA"
                     /protein_end="184"
                     /protein_start="164"
                     /score="24.2"
                     /tool="antismash"
                     /translation="AFLQYSSGSTSQPKGVMVTH"
     CDS_motif       5195..5281
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkA_0002"
                     /evalue="2.30E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="rkA"
                     /protein_end="419"
                     /protein_start="390"
                     /score="45.5"
                     /tool="antismash"
                     /translation="DGQVGEIWLRGPSVARGYWNRPEATDETF"
     gene            5864..6178
                     /gene="rkB"
     CDS             5864..6178
                     /NRPS_PKS="Domain: ACP (24-94). E-value: 1.1e-18. Score:
                     59.2. Matches aSDomain: nrpspksdomains_rkB_ACP.1"
                     /codon_start=1
                     /gene="rkB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047:phosphopantetheine-binding domain-containing
                     protein (Score: 76.3; E-value: 2.8e-23)"
                     /gene_kind="biosynthetic-additional"
                     /note="RkB"
                     /product="acyl carrier protein"
                     /protein_id="ACZ65475.1"
                     /sec_met_domain="PP-binding (E-value: 2.6e-16, bitscore:
                     49.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIAPDTRTAIRPQTPVLAPADLEKWLIDRVAFHLHRPAREIDPT
                     TPLADYGIDSVAAIGICGEIEERHLLAVPPTLAYDFPTVRAIAGHLAELLAVGDAGAAS
                     "
     aSDomain        5936..6145
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rkB_ACP.1"
                     /evalue="1.10E-18"
                     /label="rkB_ACP.1"
                     /locus_tag="rkB"
                     /protein_end="94"
                     /protein_start="24"
                     /score="59.2"
                     /tool="antismash"
                     /translation="KWLIDRVAFHLHRPAREIDPTTPLADYGIDSVAAIGICGEIEERH
                     LLAVPPTLAYDFPTVRAIAGHLAEL"
     gene            6175..9195
                     /gene="rkC"
     CDS             6175..9195
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (6-431). E-value:
                     5.2e-162. Score: 531.4. Matches aSDomain:
                     nrpspksdomains_rkC_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (531-814). E-value: 4.3e-96.
                     Score: 313.6. Matches aSDomain:
                     nrpspksdomains_rkC_PKS_AT.1"
                     /NRPS_PKS="Domain: PP-binding (922-988). E-value: 2.2e-11.
                     Score: 36.1. Matches aSDomain:
                     nrpspksdomains_rkC_PP-binding.1"
                     /codon_start=1
                     /gene="rkC"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 277.8; E-value: 3.5e-84)"
                     /gene_kind="biosynthetic"
                     /note="RkC"
                     /product="type I modular polyketide synthase"
                     /protein_id="ACZ65476.1"
                     /sec_met_domain="PKS_KS (E-value: 1e-162, bitscore: 531.4,
                     seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 8.4e-97, bitscore: 313.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.3e-12, bitscore:
                     36.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPEPVAVVGLDCRFPGARDAGEFWNLLMEGRDGTRRVPEERWE
                     ADRYMLADPAAPGEARPPGRSNTVRGGFIDDPDAFDPAFFGISPREAAAMDPQQRLLLQ
                     CSWRAIEDAAVAPEDLAGTDTGVFVGVMANEWAHLQLADYDGITARHGSGNGYFMGANR
                     VSYHLDLKGPSLAVDTACSSSLVALHLASGALRAGDCDYALAGGTNLIMTPVLNIFYTQ
                     AGLSAPDGRCKPFSASADGIGRAEGVAVLVLRRLADALADRQPVYAVLRGTGVNQDGRS
                     NGITAPNRWAQQQLIERVWRSAEVGADDIGFIEAHGTGTLLGDMMEAQALGHLTSGRSG
                     GSVALGSVKSNFGHAEGAAGIAGVVKTVLALHHRTVPPSRFADDENPGLQLPDRRLSLL
                     RSPLRLPSGTVHAAVSSFGMGGTNAHAVLSSPPRAVHRSAERVPGVFTVSARSARQLRP
                     NLLAQADALARLPEDRLAQLCWTSNRVKSRLPHRVAVAAGDLASVVAGLREAAERAHDE
                     EGGVRRTAPTVAFAFTGQGAQHPGMAASWYATSPVYARLFDEIDEHLAGHLGFSVRDAV
                     LAGDPGVHRTGLAQPALFAVEYAMAGALADAGIRPAAVIGHSIGEFAAACAAGVLEAAD
                     AARLVARRGALMEALPDGGGMLAVPLPEAEVAALLTDPARVCVAAVNGPRSTVVAGELD
                     ELALLRGTLADRGVNARPLTVSHAFHSPLMRPAVEPFRHEGTDVAAGAPSVPVFSTVYG
                     RVMGGEERMDADYWARQITAPVRFADAAAELFSSGVTHIVEVGPRAVLTPMLARLRPAD
                     ADPVSCLAAHPGERAPRHPLHHLLGQLWSAGADPTWDSLYPEADRVPRRLPPYVFDDSF
                     RAWRSATAEPPAPHLPVDAAAARPPVADLADPCPPTPDGGSPHGVSEVTHRLVCRVGGH
                     DPSAVRDRSRLAEDLGFDSIQVMELKTRIENELPELGSLPVEELLASLETVGDLARYLG
                     ERLLVPTAPSAPEGPRT"
     aSDomain        6193..7467
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rkC_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="5.20E-162"
                     /label="rkC_PKS_KS.1"
                     /locus_tag="rkC"
                     /protein_end="431"
                     /protein_start="6"
                     /score="531.4"
                     /tool="antismash"
                     /translation="VAVVGLDCRFPGARDAGEFWNLLMEGRDGTRRVPEERWEADRYML
                     ADPAAPGEARPPGRSNTVRGGFIDDPDAFDPAFFGISPREAAAMDPQQRLLLQCSWRAI
                     EDAAVAPEDLAGTDTGVFVGVMANEWAHLQLADYDGITARHGSGNGYFMGANRVSYHLD
                     LKGPSLAVDTACSSSLVALHLASGALRAGDCDYALAGGTNLIMTPVLNIFYTQAGLSAP
                     DGRCKPFSASADGIGRAEGVAVLVLRRLADALADRQPVYAVLRGTGVNQDGRSNGITAP
                     NRWAQQQLIERVWRSAEVGADDIGFIEAHGTGTLLGDMMEAQALGHLTSGRSGGSVALG
                     SVKSNFGHAEGAAGIAGVVKTVLALHHRTVPPSRFADDENPGLQLPDRRLSLLRSPLRL
                     PSGTVHAAVSSFGMGGTNAHAVLSSP"
     aSModule        6193..9138
                     /complete
                     /domains="nrpspksdomains_rkC_PKS_KS.1"
                     /domains="nrpspksdomains_rkC_PKS_AT.1"
                     /domains="nrpspksdomains_rkC_PP-binding.1"
                     /locus_tags="rkC"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       6688..6735
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0001"
                     /evalue="5.10E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="rkC"
                     /protein_end="187"
                     /protein_start="171"
                     /score="21.5"
                     /tool="antismash"
                     /translation="GPSLAVDTACSSSLVA"
     CDS_motif       6877..6915
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0002"
                     /evalue="1.10E-02"
                     /label="PKSI-KS_m4"
                     /locus_tag="rkC"
                     /protein_end="247"
                     /protein_start="234"
                     /score="9.2"
                     /tool="antismash"
                     /translation="FSASADGIGRAEG"
     CDS_motif       7108..7155
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0003"
                     /evalue="1.30E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="rkC"
                     /protein_end="327"
                     /protein_start="311"
                     /score="11.2"
                     /tool="antismash"
                     /translation="FIEAHGTGTLLGDMME"
     CDS_motif       7210..7254
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0004"
                     /evalue="1.90E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="rkC"
                     /protein_end="360"
                     /protein_start="345"
                     /score="10.9"
                     /tool="antismash"
                     /translation="GSVKSNFGHAEGAAG"
     CDS_motif       7390..7422
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0005"
                     /evalue="2.60E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="rkC"
                     /protein_end="416"
                     /protein_start="405"
                     /score="-1.3"
                     /tool="antismash"
                     /translation="PSGTVHAAVSS"
     CDS_motif       7768..7815
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0006"
                     /evalue="4.00E-05"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="rkC"
                     /protein_end="547"
                     /protein_start="531"
                     /score="16.2"
                     /tool="antismash"
                     /translation="FTGQGAQHPGMAASWY"
     aSDomain        7768..8616
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rkC_PKS_AT.1"
                     /evalue="4.30E-96"
                     /label="rkC_PKS_AT.1"
                     /locus_tag="rkC"
                     /protein_end="814"
                     /protein_start="531"
                     /score="313.6"
                     /tool="antismash"
                     /translation="FTGQGAQHPGMAASWYATSPVYARLFDEIDEHLAGHLGFSVRDAV
                     LAGDPGVHRTGLAQPALFAVEYAMAGALADAGIRPAAVIGHSIGEFAAACAAGVLEAAD
                     AARLVARRGALMEALPDGGGMLAVPLPEAEVAALLTDPARVCVAAVNGPRSTVVAGELD
                     ELALLRGTLADRGVNARPLTVSHAFHSPLMRPAVEPFRHEGTDVAAGAPSVPVFSTVYG
                     RVMGGEERMDADYWARQITAPVRFADAAAELFSSGVTHIVEVGPRAVLTPMLARLRPAD
                     AD"
     CDS_motif       7942..7977
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0007"
                     /evalue="4.20E-04"
                     /label="PKSI-AT-M_m2"
                     /locus_tag="rkC"
                     /protein_end="601"
                     /protein_start="589"
                     /score="13.0"
                     /tool="antismash"
                     /translation="QPALFAVEYAMA"
     CDS_motif       7996..8118
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0008"
                     /evalue="1.20E-21"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="rkC"
                     /protein_end="648"
                     /protein_start="607"
                     /score="69.0"
                     /tool="antismash"
                     /translation="GIRPAAVIGHSIGEFAAACAAGVLEAADAARLVARRGALME"
     CDS_motif       8209..8247
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0009"
                     /evalue="1.40E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="rkC"
                     /protein_end="691"
                     /protein_start="678"
                     /score="15.0"
                     /tool="antismash"
                     /translation="AAVNGPRSTVVAG"
     CDS_motif       8470..8505
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkC_0010"
                     /evalue="4.10E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="rkC"
                     /protein_end="777"
                     /protein_start="765"
                     /score="13.8"
                     /tool="antismash"
                     /translation="YWARQITAPVRF"
     aSDomain        8941..9138
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rkC_PP-binding.1"
                     /evalue="2.20E-11"
                     /label="rkC_PP-binding.1"
                     /locus_tag="rkC"
                     /protein_end="988"
                     /protein_start="922"
                     /score="36.1"
                     /tool="antismash"
                     /translation="LVCRVGGHDPSAVRDRSRLAEDLGFDSIQVMELKTRIENELPELG
                     SLPVEELLASLETVGDLARYL"
     gene            9192..10223
                     /gene="rkD"
     CDS             9192..10223
                     /codon_start=1
                     /gene="rkD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 294.8; E-value: 1.2e-89)"
                     /gene_kind="biosynthetic-additional"
                     /note="RkD"
                     /product="3-oxoacyl-(acyl carrier protein) synthase III"
                     /protein_id="ACZ65477.1"
                     /sec_met_domain="fabH (E-value: 1.4e-38, bitscore: 122.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPSPAPVAHLVSVGTCLPGEPVDNATLAKLVGVDEQWAEMFIGN
                     VSRHFAVDLATGQVRHSLADIAATAADRALAAAGLEAVDIDCVVMGTATPDQLMPATVN
                     LVADRLGIDNVPTYQLQSGCAGAVQALDVARTLLLAGRCSTVLVIGGDVCAKHLETDFD
                     PGSRTPGELVNYILFGDGAGAAVLSAESFGERVEIRQVLNRLVGLGKAPGQVIDWFGLG
                     DRHSDRIAISEDYKAIEAAVPVLATQMFWELIGDVGWTADQVDYLLPPQLSGRMSDRIS
                     DAMPAPLAQRVNVVRTVGNNGNALPFLQLAELLGQWQGGGRAVTVAVESSKWIKSGIAL
                     ERA"
     gene            10220..12145
                     /gene="rkE"
     CDS             10220..12145
                     /NRPS_PKS="Domain: FkbH (279-415). E-value: 2.9e-37. Score:
                     119.5. Matches aSDomain: nrpspksdomains_rkE_FkbH.1"
                     /codon_start=1
                     /gene="rkE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1256:FkbH like protein (Score: 444.4; E-value:
                     3.8e-135)"
                     /gene_kind="biosynthetic-additional"
                     /note="RkE"
                     /product="FkbH-like glyceryl-S-ACP synthase"
                     /protein_id="ACZ65478.1"
                     /transl_table=11
                     /translation="MTTITANASSAGGSWQDPEALRTLRDLYAAGRLEAEYPSVRPLLA
                     RLPERQLPAAGQLLARLDRDDVVRHHADVPVVTVAVTGQSTVAPLVAPLTAELARHGLL
                     LDPVVSPYGSYLADLLGPGGAEQDRRPTLTLCLLDAHTVFEEVPLPWRVEDVEAAARSR
                     LALISRAVRAHQDGGRGPLVLNTVPLLHRHARQLVDLRSRARLGVVWREFNSGLLALAE
                     EHPGLIVVDLDPLIAQGTPAYEPRTGLYAKARLAEGLLASYARDVGHLVTGLLGRTRKC
                     LVLDLDGTLWGGVLGEDGVDGVELGSGFRGEAFAEFQRVVAQLGSQGVLLAVSSKNDDA
                     KVREALREHPSMLLREDDFVRVNANWSAKHDNLRDIAERVGIGLDSFVFVDDSTFECGL
                     VREQLPQVAVVRVDEEPALHPAALLADGWFDLPVLTDEDRERAGRYRTEARRQEFREDT
                     GSYQDYLDGLGIEVTVRPPEPAELSRVSQLTLRTNQFHLAPERLQLPQVREWAERPDRG
                     VLAVRARDRFGDHGLVGAVFWRRDAEDLHIDNYVLSCRVFSRGIESACLAAVLEHAAAS
                     GAHGALARHRPTPRNAAFASFYIDHGFVPTGVAPDDPATVVFRHALRDITPAPAHLRLH
                     TAFEEN"
     aSDomain        11057..11464
                     /aSDomain="FkbH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rkE_FkbH.1"
                     /evalue="2.90E-37"
                     /label="rkE_FkbH.1"
                     /locus_tag="rkE"
                     /protein_end="415"
                     /protein_start="279"
                     /score="119.5"
                     /tool="antismash"
                     /translation="KCLVLDLDGTLWGGVLGEDGVDGVELGSGFRGEAFAEFQRVVAQL
                     GSQGVLLAVSSKNDDAKVREALREHPSMLLREDDFVRVNANWSAKHDNLRDIAERVGIG
                     LDSFVFVDDSTFECGLVREQLPQVAVVRVDEE"
     gene            12148..12387
                     /gene="rkF"
     CDS             12148..12387
                     /NRPS_PKS="Domain: PP-binding (10-75). E-value: 6.9e-09.
                     Score: 28.0. Matches aSDomain:
                     nrpspksdomains_rkF_PP-binding.1"
                     /codon_start=1
                     /gene="rkF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="RkF"
                     /product="acyl carrier protein"
                     /protein_id="ACZ65479.1"
                     /sec_met_domain="PP-binding (E-value: 1.4e-09, bitscore:
                     28.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATAIADAAEFCALLEDELGIRLAPEDLDRPLDEVAEWDSVHLL
                     RLVTVVENVTGRRVPVADLLEAVTFQQMYEVVRA"
     aSDomain        12178..12372
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rkF_PP-binding.1"
                     /evalue="6.90E-09"
                     /label="rkF_PP-binding.1"
                     /locus_tag="rkF"
                     /protein_end="75"
                     /protein_start="10"
                     /score="28.0"
                     /tool="antismash"
                     /translation="EFCALLEDELGIRLAPEDLDRPLDEVAEWDSVHLLRLVTVVENVT
                     GRRVPVADLLEAVTFQQMYE"
     gene            12384..13187
                     /gene="rkG"
     CDS             12384..13187
                     /NRPS_PKS="Domain: Thioesterase (23-251). E-value: 5.9e-36.
                     Score: 116.8. Matches aSDomain:
                     nrpspksdomains_rkG_Thioesterase.1"
                     /codon_start=1
                     /gene="rkG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 207.5; E-value: 2.7e-63)"
                     /gene_kind="biosynthetic-additional"
                     /note="RkG"
                     /product="type II thioesterase"
                     /protein_id="ACZ65480.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4e-11, bitscore:
                     33.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGPATAAPAGCLVRAPREDAALRLFCFHHAGGGASFYAPWPARV
                     APGVDVLPVQLPGRESRFRERRFQDAGTLAEALADELAPWLDRPYAVYGHSMGALIGFA
                     VAAARMRAGGRAPLALYVGAYAAPHLTPPLPPADLYGDADLARLLVDIGGLHPQFLGRD
                     DWLRALLPIVRDDLRICASHREAGLPDPDDAEQRLPLHIRAFAGSDDTLVDPGAVHAWE
                     RYARDFRLTTVPGGHFFPREAPEPFFEELNRSLAALLTEARQAPA"
     aSDomain        12453..13136
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rkG_Thioesterase.1"
                     /evalue="5.90E-36"
                     /label="rkG_Thioesterase.1"
                     /locus_tag="rkG"
                     /protein_end="251"
                     /protein_start="23"
                     /score="116.8"
                     /tool="antismash"
                     /translation="RLFCFHHAGGGASFYAPWPARVAPGVDVLPVQLPGRESRFRERRF
                     QDAGTLAEALADELAPWLDRPYAVYGHSMGALIGFAVAAARMRAGGRAPLALYVGAYAA
                     PHLTPPLPPADLYGDADLARLLVDIGGLHPQFLGRDDWLRALLPIVRDDLRICASHREA
                     GLPDPDDAEQRLPLHIRAFAGSDDTLVDPGAVHAWERYARDFRLTTVPGGHFFPREAPE
                     PFFEEL"
     CDS_motif       12456..12482
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkG_0001"
                     /evalue="4.40E-03"
                     /label="NRPS-beforete1"
                     /locus_tag="rkG"
                     /protein_end="33"
                     /protein_start="24"
                     /score="10.1"
                     /tool="antismash"
                     /translation="LFCFHHAGG"
     CDS_motif       12597..12704
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rkG_0002"
                     /evalue="1.20E-06"
                     /label="NRPS-te1"
                     /locus_tag="rkG"
                     /protein_end="107"
                     /protein_start="71"
                     /score="21.0"
                     /tool="antismash"
                     /translation="GTLAEALADELAPWLDRPYAVYGHSMGALIGFAVAA"
     CDS             complement(13197..14048)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     55.7; E-value: 8.3e-17)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf1*"
                     /product="putative beta-lactamase domain-containing
                     protein"
                     /protein_id="ACZ65481.1"
                     /transl_table=11
                     /translation="MPTIDILLPGFAIDTDQGYPAFCGVFLVRGADATGRPRTVLVDAA
                     HVGRRPHLWAALAAHGLTAADIDTVVLTHAHWDHVQNIDLFPRAELLLHGDERRYAHAP
                     HSNDWATPAWTGLLLEQLPIREVADGEEILPGVHVIALPGHSPGSIGVLVDTDAGVAAI
                     TGDALHFAYVATTRRNPLVFWDAELAARSIDRVVGAADVIYPGHDRPFRLTSDGAIDYQ
                     EPFALTVTGLRPDTEGLAFADGSSRPLWVMPGVDEQRTLYEKNAEEARRRMAGVPRVVR
                     PR"
ORIGIN
        1 cgcctcgggc gtgcctgtgc gaacggtcag acggacggcg cgggttcggg cgccggggcc
       61 gcggccggcg gggtctcggc gagccaggag aagacccggt cgtggaagag ggtcatggag
      121 ccggagtggc agtgggctcc cccgccctcg tccgcggtga acacgtgcag ggtcttgggg
      181 ccgcccaggc ccgtgtacac cttcttcgcg tgttccagac cggcgaagaa catgtcctcc
      241 tcggcgtcga gcaccaggac cggacagcgc acctgcccga ccacgtccgc gaggccgaac
      301 gcgggcatcc ggcgcagcag ttcggagggg ctctgcgccc cgaacgtcca catcgcctgc
      361 cgcagcagcc agcgcggaag gtctgctgca cggcgatccc gtacatcacc gggttggcga
      421 agtcgtcgca gccctgctcc acccactcgt ggacgaacgg cggcagccag acgacgtccc
      481 cgagctgcca gaccgcgtca tgggcgacgc atccggcgag ccggtgctcg aacgcggcgg
      541 cccggacggc gagcagcccc ccgaggctgg tccccaccag ggtgacgcgc tcggggtcca
      601 cccccggccg ggccagcgcg aagtcgacca cgggcgtgac cacctcctcc cagtccggcc
      661 ggaaggtgag cccctgctcg cgcagcaccg agccctgccc gggcccttcg aagcagagga
      721 cgtggtagcc gcgcgcctgg gcggcggccg cgatgaagaa gtagccctct tcgagcgtgg
      781 agtcgatgcc gccgtggtgg atgagggtcg ggcgcggccc ggcggagtcg tcggcgcggt
      841 agaagtaccc gggcagcgag ccgtccccgt acgggatgcg gacgaactcc gggggtcgct
      901 ccatgagccc ggccgcctcg gcgaaggtct ccttggagag ccgcatcagc cgcgccgcct
      961 cggggtcgtg caacgggtcg tcgcgcagga agaactcggc ggtgcggtag tacgtgtggg
     1021 cgcgcagcag ggccgcgcgg gcgtcgaggg tgcggtgctg ggcgagcgcg gcggtggcga
     1081 ggccgtggac gcgttcggca agcgcggtcc actcgcgccg ccaggcgtcc gtgtcgccgc
     1141 cggggatgcg cgaggcgacg gcgatgatct cgccgagctg ggccccgccg aagtcggcgt
     1201 agccggcggc tcgtagggcc tggtagtcga aggcggggtc gtcgaagagg aacttcatgg
     1261 ttgcggctcc tgcatgggga ggcggttctg gtacccgtcc gcgcggacgg gcggatggcg
     1321 ctgcggccga ccagtgcgtg cgcccgggct cccggttccc ggtccggtgg gcgcggcccg
     1381 gctaccgggg tgcggggttg ctccgggtgc cgtcgaggaa ggtgtccacg atcgcctcgg
     1441 cgaacgcggc ggactccacc ggccgctgac gcaggatcag ccgcgcgagc atcgggcccg
     1501 tgagcagctc gatggcctgg tcgacgtcga ggccggggcg cagctctccg ctgtccagcc
     1561 cgtcgcgcag cacctgccgc atggcgtccc tccgtgcggc gaccgcggtg ttctcgtacg
     1621 cctccaccag ctgcggccgg tgcaccgcct ctccgaggag gccggccagc aggcggtgca
     1681 gatgggtgtc ctggccgcgg tggcggatct ggtcgaccag atccaccaga cgctcccgca
     1741 ggggcagtcc gtccgagggg gtgacgggca cgtcgaggct gctcagggcc gcgagcacca
     1801 gctcttcctt gttgcgccag cggcggtaga tggtggcgcg ggcgaccccg gcacgctggg
     1861 ccaccaggtc catcgacagc gcgctgaagc tgcacccctc gcccagcagg cccagggtgc
     1921 tctccaggat cgcccggtcg gccgcggggt cgcgctggcg cccgccgcgg gcggtgcgct
     1981 gcgcgggggc gtgcccgtcc ccggtcgcgg ggacgggccg gaggccggtg ggcgcggcgc
     2041 cctcggcctc cggtggaacg ggtggtggca tgctcagacc tccgaggagt ggtggaccct
     2101 ggccgcctcg ggcgcgccgg ctccttcgtc gggcgtacgg gcgggcagca ggagcaggct
     2161 gacgagggtg ccgaggaagg tgaccccggc ggcgaccagt gcggtgacgt gcatcgcgga
     2221 gacgaacgag tcgacggcgt ggcccgcgag agaggcgccg cgcgggccga gcgcgtcggc
     2281 cgcggcgagg ctgctctgca cggactcccc cgccttgtcg cgcagttggt ccggcacggc
     2341 tcccaggtgg tccgacatcc gcgagcggta ggcggtggag agcaccgagc cgaggacggc
     2401 gacgccgagc gccccgccca cctggcggaa ggtggtgttg acggccgagc cggtgcccgc
     2461 ccgttgccgg ggcagggccg acatgacggc ggcggtggcg ggcggcatca cacaggcgat
     2521 gcccacgccc aggacgaaga agacggattc gagcagccac agcgaggtgt gctcgtcgac
     2581 ggtggcgacg gtgacgaacg ccagggtggt cagcagcatc ccggtggtgc acaccgggcg
     2641 caccccgatg cgcttggccg cgagcgtggc gggcggcgag aacgccaact gggccacggc
     2701 cagcggcagc aggcagtacc cggcctgcag gggcgtccag ccgcgcacgc tctgcagata
     2761 gaagaccagg aagaaggtgg cgccgagcag cgcgaagaac accaggccga tcacggtcac
     2821 ggcggccgag aagcgcggga cgcggaacag ggcgatgtcg agggccgggc gctcggcccg
     2881 ccgctcccaa ccgacgaaga ccgccagcac gacgagcccg ccgagcatcg tcccccacac
     2941 ccgccccgcc gcccagtcgt ccgactcgcc gccctggatc accccgtaca cgagcagggt
     3001 cagacccgcc acggacaggg cgacgcccac cgggtcgaag ccgccgcgcc cggggtccct
     3061 ggactccggc acgacgacca gcgcggcgac ggtgccgatc acgacgatcg ggatgttgat
     3121 gaggaagacc gagccccacc agaagtgctc caggagcgcg ccgccggtga tgggcccgac
     3181 ggcgaccgcc agacctgcgg ccccggccca gatgccgacg gccttggcgt gttcggcggg
     3241 cgggaagacg ttcatgatga tcgccagggt cgcgggcatc accagcgccc cgccgacgcc
     3301 gagtccggcg cgggcggcga tgagttcgcc ggcgctgccc gcgtaggcgg accagagcga
     3361 gcagccgccg aagacgacga gcccggtcac cagcgtgcgt ttgcggcccc agcggtcggc
     3421 cagcactccg gtgctgaaca ggagggccgc gaagacgagc gtgtacgagt ccaccgacca
     3481 ctgcagtgcg ctggaggagg cgcccaggcc ctgcggtgcg ggctcggcga gcgtcttgag
     3541 cgcgacgttg aggatcgagg tgtcgaggac cacgagcagg aggctgacca cgagcacgcc
     3601 cagtacccac cagcggtggg cggcggcctg gtcctgctcg gtcttgcggg gttcgagctg
     3661 agtggtcacg ggatgccgct cctcggaagg aagagggtgt tgcgtgaact gccgtctgca
     3721 gctgtgcggt tgacgacgct agacccgccc accaatcgag tcaatggcgt atcgaaacag
     3781 tgctgactca catctgggtg acgggagagt gaggcgagct tgcggcactg ggtgccaact
     3841 tctgctccct acacgtgtga acgccccttg cgctccccct ctccggcaca ccctgcggga
     3901 acctccgaag ctgcgacgtg cacctcaagg ctgcctttac acgtcctttt cgcttcccac
     3961 caacgatggg tcgacagatg gcacttggtg ccgcgccagc ccggacagac cgacagggga
     4021 agagatgcac cagacgttga ccgaggccgt acgtgccggg gccgagcagc accccgaccg
     4081 gctcgcgttc gtgtacctgc acgaggacgg ccggaccatg cggcccgagg agctcaccta
     4141 cgccgaactg gaccgccgcg cccggctgat cgccacccgg ctgcgccagg agtcgctggg
     4201 cgacccgtcc cgcccggtgc tgctgctcta tccgcccacg ctcgacttcg tcaccgcgtt
     4261 cctcggctgc ttctacgccg ggcgcacggc catccctgcg ccgctgccgg acgagccggg
     4321 cgagcgcctg gcccgggtca gcggcatcct gcgggacgcc tcggtgggcg cggtcctgac
     4381 gctgcccgag caccgccaag ggctcgccgc ctggctggcc gcctccgggg agcaggacgt
     4441 ggtgtgcctg gcgcccgagg acgacggcga ggaccccgcg ctgtggttcc cgccgcaggt
     4501 ccgcgccgac gacatcgcct tcctccagta cagctcgggc tccaccagcc agcccaaggg
     4561 cgtcatggtc acccacgcca acctggccgc caaccaggag gccatccacc acgccatgct
     4621 caccacgccc ggcgtcgtca ccggcagctg gctgccgctc taccacgaca tgggcctcat
     4681 cgggatgacg ctgcacccgc tgtggatggg cggcacgagc gtccagatgt cgccgatctc
     4741 cttcatcaag cagccgcacc gctggctgcg gatgatccac gactaccgcg tcgagggcac
     4801 cgcctcgccc gacttcgggt acgagctgtg cgcccgccgc accaccgacg agcaggccga
     4861 ggggctcgac ctgtccagcc tgcgggtggc gctcaacggc gccgagccgg tgcgcgccgc
     4921 caccatccgc accttcaccg cgcgcttcgc cgcccaggga ctgcgccccg aggcactgtt
     4981 cccctgctac gggctggccg agaacaccct gctcgcctcg gccggggaca ccaccgcccc
     5041 gcacgtcgaa ctcgccgtgg acgcgcacct cctggagcag cacgagctgc ggcccgcccg
     5101 ccccgaccgc acctcccgga cgctggtggg ctgcggcaca ccggccggca gcgaggtgct
     5161 catcgtcgac cccatgacgt gccaggcgct ggcggacggc caggtcggcg agatctggct
     5221 gcgcggcccg tccgtggcgc gcggctactg gaaccgcccc gaggccaccg acgagacctt
     5281 ccgcgccgag accgccgacg gccgcaacgg ctatctgcgc accggcgacc tcggcggact
     5341 ggtcggcggg gagctgttcg tcaccggccg catcaaggag atgctcatcc accacggccg
     5401 caacctctac ccgcaggaca tcgagcaggc cgtgcaggac tcggggcccg ccctgcggcg
     5461 cggcggcggg gcggtgttca ccgtcgggga cgaggagggc gagcgctcgc acgtcgtggt
     5521 ggtgcaggag gtccgcccca accagcaggg cgagcacgac ctgcccgccc tcgccgcctc
     5581 ggtccagacg gtgctcagcc gccggttcca gctccccgcc gccagtgtgg tcctggtgcg
     5641 ccccggcgcg atccgcaaga ccaccagcgg caagacacag cgcaccctga tgcgccggct
     5701 gttcctcgac ggcgccctgt ccgtactcca ccagcgcctg gagcggccgg tcgcggagct
     5761 cgtcgcccgc ccggccgaga cccccgagca ctcggctccg ctggccgccc ccggccgctg
     5821 agcccgcccg gcccaccgag cgcccccaag gaagaggtac ctcatgtcca tcgcccccga
     5881 cacccgcacc gcgatccgcc cgcagacccc ggtcctcgcc cccgcggacc tggagaagtg
     5941 gctcatcgac cgggtggcct tccatctgca ccggcccgcc cgggagatcg acccgaccac
     6001 cccgctcgcc gactacggca tcgactcggt ggccgccatc ggcatctgcg gcgagataga
     6061 ggagcgccac ctgctggcgg tcccgccgac cctcgcgtac gacttcccga cggtgcgcgc
     6121 gatcgccggg cacctggcgg agctgctcgc cgtgggggac gccggggccg cctcgtgagc
     6181 gcacccgaac cggtcgcggt cgtcgggctc gactgccgct tccccggggc ccgggacgca
     6241 ggcgagttct ggaacctcct gatggagggc cgggacggca cccggcgcgt ccccgaggag
     6301 cgctgggagg cggaccgcta tatgctcgcc gacccggccg ccccgggcga ggcccggccg
     6361 cccggccgct ccaacaccgt gcgcggcggc ttcatagacg acccggacgc cttcgacccg
     6421 gccttcttcg ggatctcgcc gcgcgaggcg gccgccatgg acccgcagca gcggctgctg
     6481 ctccagtgct cctggcgcgc catcgaggac gcggcggtgg cccccgagga cctggccggc
     6541 accgacacgg gcgtgttcgt gggggtgatg gccaacgagt gggcccacct ccaactggcc
     6601 gactacgacg ggatcaccgc ccggcacggc tccggcaacg gctacttcat gggcgccaac
     6661 cgcgtctcgt accacctgga cctcaagggt cccagcctgg cggtggacac ggcctgctcg
     6721 tcctcgctcg tggccctgca cctcgcctcc ggcgcgctgc gcgcgggcga ctgcgactac
     6781 gcgctcgccg gcggcaccaa cctgatcatg acgcccgtcc tcaacatctt ctacacccag
     6841 gcgggcctgt ccgcgcccga cggccgctgc aagccgttca gcgcctccgc agacggcatc
     6901 ggccgcgccg agggggtcgc cgtgctcgtg ctgcggcggc tcgccgacgc gctcgccgac
     6961 cgccagcccg tctacgcggt gctgcgcggc accggcgtca accaggacgg ccgcagcaac
     7021 gggatcaccg cgcccaaccg ctgggcccag cagcagctca tcgagcgggt ctggcgctcg
     7081 gccgaggtcg gcgccgacga catcggcttc atcgaggccc acggcaccgg caccctcctc
     7141 ggcgacatga tggaggccca ggcgctcggc cacctcacca gcggccgcag cggcggcagc
     7201 gtcgcgctcg gctcggtcaa gagcaacttc gggcacgccg agggcgccgc cgggatcgcc
     7261 ggtgtcgtca agacggtcct ggcgctgcac caccgcacgg tgccgcccag ccgcttcgcc
     7321 gacgacgaga acccggggct ccaactgccc gaccgacgcc tgtcgctgct caggtcgccg
     7381 ctgcggctgc cgtccggcac cgtgcacgcc gccgtcagca gcttcggcat gggcggcacc
     7441 aacgcccacg ccgtgctctc ctccccgccg cgcgcggtcc accgctccgc cgagcgggtc
     7501 ccgggggtgt tcaccgtctc cgcccgctcc gcgcgccagc tgcgccccaa tctgctggcg
     7561 caggccgacg cgctggcccg gctgcccgag gaccggctcg cccagctgtg ctggaccagc
     7621 aaccgcgtca agtcccggct gccgcaccgc gtcgccgtcg ccgcgggcga cctggcgtcc
     7681 gtggtggccg ggctgcgcga ggcggccgag cgcgcccacg acgaggaggg cggggtgcgg
     7741 cgcacggcgc ccacggtggc gttcgcgttc accgggcagg gcgcccagca ccccggcatg
     7801 gccgcctcct ggtacgccac ctcccccgtc tacgcccgcc tcttcgacga gatcgacgag
     7861 cacctggcgg gccacctcgg cttctcggtg cgcgacgcgg tcctggcggg cgatccgggc
     7921 gtgcaccgca cgggcctcgc ccaaccggcg ctcttcgccg tcgagtacgc gatggcgggc
     7981 gccctggccg acgccgggat ccggcccgcc gccgtcatcg gccacagcat cggcgagttc
     8041 gccgccgcgt gcgcggccgg agtgctcgaa gcggccgacg cggcccgcct cgtcgcccgc
     8101 cggggcgcgc tcatggaggc gctcccggac ggcggcggca tgctcgccgt accgctgccc
     8161 gaggcggagg tggcggcgct gctcaccgat cccgcgcggg tgtgcgtcgc ggccgtcaac
     8221 ggtccgcgca gcacggtggt cgccggtgag ctcgacgaac tcgccctgtt gcgcggcacg
     8281 ttggccgacc gtggcgtcaa cgcccgcccg ctgaccgtct cgcacgcctt ccactccccg
     8341 ctgatgcggc ccgccgtcga accgttccgg cacgagggca cggacgtggc ggcgggcgcc
     8401 ccctcggtgc cggtcttctc gacggtgtac gggcgggtca tgggcggcga ggagcgcatg
     8461 gacgccgact actgggcgcg ccagatcacc gcaccggtgc ggttcgccga cgccgccgcc
     8521 gagctgttct cgtccggcgt cacccacatc gtggaggtcg gcccgcgcgc cgtgctcacc
     8581 cccatgctcg cccggctccg gccggccgac gcggacccgg tgagctgcct cgccgcccac
     8641 cccggcgagc gcgcgccccg ccacccgctg caccacctgc tcgggcagct gtggagcgcc
     8701 ggggccgacc ccacctggga cagcctgtac ccggaggcgg accgtgtgcc gcgccggctg
     8761 ccgccgtacg tcttcgacga cagcttccgc gcctggcgct ccgccaccgc cgaaccgccc
     8821 gcgccccacc tccccgtgga cgcggcggcc gcgcggccgc cggtggcgga cctcgcggac
     8881 ccgtgcccgc cgaccccgga cggtggttcc ccccacgggg tgtccgaggt gacgcaccgt
     8941 ctggtgtgcc gggtcggcgg gcacgacccc tcggcggtac gggaccgctc ccgcctcgcc
     9001 gaggacctcg gcttcgactc gatccaggtc atggagctca agacccgcat cgagaacgag
     9061 ctgcccgagc tcggcagcct gcccgtcgag gagctgctcg cgagcctgga gacggtgggc
     9121 gacctcgccc gctatctggg cgagcgcctc ctcgtaccga ccgcaccgtc cgccccggaa
     9181 ggaccgcgca catgagtccg tcacccgccc ccgtcgccca cctggtctcg gtcggcacct
     9241 gtctgccggg ggaaccggtg gacaacgcca ccctggccaa gctcgtcggc gtcgacgagc
     9301 agtgggccga gatgttcatc ggcaacgtca gcaggcactt cgccgtcgac ctggcgaccg
     9361 gccaggtccg ccactccctc gcggacatcg cggcgaccgc ggcggaccgg gccctcgcgg
     9421 cggcgggcct ggaggccgtc gacatcgact gcgtcgtcat gggcaccgcc acccccgacc
     9481 agctgatgcc cgccaccgtc aacctggtgg ccgatcgcct cggcatcgac aacgtgccca
     9541 cctaccagct ccagtccggc tgcgccgggg ccgtccaggc gctcgacgtg gcccgcaccc
     9601 tgctcctcgc cgggcgctgc tcgacggtcc tggtgatcgg cggcgacgtc tgcgccaagc
     9661 acctggagac ggacttcgac cccggctcgc gcacccccgg cgagctggtc aactacatcc
     9721 tgttcggcga cggggcgggc gcggccgtgc tcagcgccga gtcgttcggg gagcgcgtgg
     9781 agatccgcca ggtcctcaac cgcctggtgg gcctgggcaa ggcgcccggc caggtcatcg
     9841 actggttcgg cctgggcgac cggcacagcg accgcatcgc gatctccgag gactacaagg
     9901 cgatcgaggc ggcggtgccg gtcctcgcca cccagatgtt ctgggagctc atcggcgacg
     9961 tcggctggac ggccgaccag gtggactatc tgctgccgcc ccagctctcc ggccggatga
    10021 gcgaccgcat ctccgacgcg atgcccgccc cgctcgccca gcgcgtcaac gtggtgcgca
    10081 cggtcggcaa caacggcaac gccctgccct tcctccagct cgccgaactg ctcggccagt
    10141 ggcagggcgg cgggcgcgcg gtcaccgtcg ccgtggagtc cagcaagtgg atcaagtccg
    10201 gcatcgccct ggagcgcgca tgaccaccat cacggcaaac gcctcttcgg cgggcggcag
    10261 ttggcaggac ccggaggcgc tgcgcaccct gcgcgacctg tacgcggccg ggcgcctgga
    10321 agccgagtac ccgtcggtac ggccgctgct cgcccggctc ccggagcggc agctgcccgc
    10381 cgcgggccag ttgctcgccc ggctcgaccg cgacgacgtc gtccgccacc acgccgacgt
    10441 gcccgtggtg accgtcgccg tcaccggcca gtccaccgtc gccccgctgg tcgccccgct
    10501 caccgcggag ctggcgcgcc acgggctgct gctcgacccg gtggtctcgc cgtacggctc
    10561 gtatctggcg gacctgctcg ggcccggcgg cgccgagcag gaccggcggc ccacgctcac
    10621 gctgtgcctg ctggacgcgc acaccgtctt cgaggaggtg ccgctgccct ggcgggtcga
    10681 ggacgtcgag gccgcggcca ggtcccggct cgcgctgatc tcccgggccg tccgcgccca
    10741 ccaggacggc gggcgcggcc cgttggtcct caacacggtc ccgctgctgc accgccatgc
    10801 ccgccagctg gtggatctgc gctcccgggc ccggctcggc gtcgtctggc gcgagttcaa
    10861 cagtgggctg ctcgcgctcg ccgaggagca ccccgggctg atcgtcgtcg acctcgaccc
    10921 gctgatcgcc caggggacac cggcgtacga gccgcgcacg ggtctgtacg ccaaggcgcg
    10981 cctcgccgag ggactgctcg cgagctacgc ccgggacgtc ggccatctcg tcaccgggct
    11041 gctcggccgg acccgcaagt gcctggtcct cgacctggac gggacgctgt ggggcggggt
    11101 gctcggcgag gacggcgtgg acggcgtcga gctcggcagc gggttccgcg gcgaggcgtt
    11161 cgccgagttc cagcgcgtgg tggcccagct cggctcgcag ggcgtgctgc tcgccgtcag
    11221 cagcaagaac gacgacgcca aggtgcgcga ggcgctgcgc gagcacccct cgatgctgct
    11281 gcgcgaggac gacttcgtcc gtgtcaacgc caactggtcg gccaagcacg acaatctgcg
    11341 cgacatcgcg gagcgggtcg ggatcggtct ggacagcttc gtcttcgtcg acgacagcac
    11401 cttcgagtgc ggtctggtcc gcgagcagct gccgcaggtc gcggtggtcc gggtcgacga
    11461 ggagccggcg ctgcacccgg ccgcgctgct cgcggacggc tggttcgacc tgccggtgct
    11521 caccgacgag gaccgcgagc gggcgggccg ctaccgcacc gaggccaggc gccaggagtt
    11581 ccgcgaggac accggctcgt accaggacta tctggacggt ctcggcatcg aggtcaccgt
    11641 gcgcccgccg gagcccgccg agctgtcccg cgtctcccaa ctcaccctgc gcaccaacca
    11701 gttccacctc gcccccgagc gcctccagct gccgcaggtg cgggagtggg ccgagcgccc
    11761 ggaccgcggt gtgctggcgg tccgcgcccg cgaccggttc ggcgaccacg gcctggtcgg
    11821 cgcggtgttc tggcgccgcg acgcggagga cctgcacatc gacaactacg tgctgagctg
    11881 ccgggtgttc tcacgcggca tcgagagcgc ctgcctggcg gccgtcctgg agcacgcggc
    11941 ggcgtccggc gcgcacggcg cgctcgcccg ccaccggccc accccgcgca acgccgcctt
    12001 cgcctccttc tacatcgacc acggcttcgt ccccaccggc gtcgcccccg acgaccccgc
    12061 caccgtcgtc ttccgccacg ccctgcgcga catcacgccc gcccccgccc atctgcggct
    12121 gcacaccgcc ttcgaggaga actgaccatg accgccaccg ccatcgccga cgccgccgag
    12181 ttctgcgcgc tcctggagga cgaactcggc atccgcctcg cccccgagga cctggaccgc
    12241 cccctcgacg aagtggccga gtgggactcg gtccatctgc tgcgcctggt caccgtggtg
    12301 gagaacgtca ccggccgccg cgtcccggtg gccgacctcc tggaggccgt gaccttccag
    12361 cagatgtacg aggtggtgcg cgcgtgagcg gccccgccac ggccgccccg gcgggctgcc
    12421 tcgtccgggc gccgcgcgag gacgcggcgc tgcggctgtt ctgcttccac cacgcgggcg
    12481 gcggggcgtc cttctacgcc ccgtggcccg cgcgggtggc gcccggagtg gacgtcctgc
    12541 cggtgcagtt gcccggccgc gaatcacggt tccgcgagcg gcggttccag gacgccggga
    12601 ccctggccga ggccctcgcc gacgaactcg ccccgtggct ggaccggccg tatgcggtgt
    12661 acgggcacag catgggcgcg ctgatcggct tcgcggtggc ggcggcccgg atgcgggcgg
    12721 gaggccgggc gccgctcgcg ctgtacgtcg gcgcgtacgc ggccccgcac ctcaccccgc
    12781 cgctgccgcc ggccgatctg tacggcgacg cggacctcgc ccgcctcctg gtggacatcg
    12841 gcgggctgca cccgcagttc ctgggccgcg acgactggct gcgcgcgctg ctgcccatcg
    12901 tccgggacga cctgcggatc tgcgccagcc accgggaggc ggggctgccg gacccggacg
    12961 acgccgagca gcgactgccg ctgcacatcc gggcgttcgc gggctcggac gacactctgg
    13021 tggaccccgg cgctgtccac gcctgggagc ggtacgcgcg cgacttccga ctgaccaccg
    13081 tgccgggagg ccacttcttc ccgcgcgagg cccccgagcc gttcttcgag gagctcaacc
    13141 gctcgctggc cgccctgctc accgaggcgc ggcaggcccc cgcgtgacgg gccggctcag
    13201 cgcggccgca ccacgcgcgg taccccggcc atgcgccgcc gggcctcctc cgcgttcttc
    13261 tcgtacagcg tgcgctgctc gtccacgccc ggcatgaccc acagcgggcg ggaggagccg
    13321 tcggcgaagg cgagcccctc ggtgtcgggc cgcagcccgg tgacggtgag cgcgaacggc
    13381 tcctggtagt cgatcgcgcc gtcggaggtg aggcggaagg ggcggtcgtg gcccgggtag
    13441 atgacatcgg ccgcccccac cacccggtcg atgctgcggg ccgcgagctc ggcgtcccag
    13501 aagaccagcg ggttgcggcg cgtggtggcc acgtacgcga agtgcagggc gtcgccggtg
    13561 atcgcggcca ccccggcgtc ggtgtcgacg aggacgccga tgctgccggg cgagtgcccg
    13621 ggcagggcga tgacgtggac gccgggcagg atctcctcgc cgtccgccac ctcccggatc
    13681 ggcagctgtt cgagcagcag gccggtccag gcgggggtcg cccagtcgtt cgagtgcggc
    13741 gcgtgggcgt agcgccgctc gtcgccgtgg aggagcagtt cggcgcgcgg gaacaggtcg
    13801 atgttctgta cgtggtccca gtgggcgtgg gtgagcacca cggtgtcgat gtccgccgcg
    13861 gtgaggccgt gcgccgcgag cgccgcccac agatgggggc ggcgcccgac gtgggcggcg
    13921 tcgaccagga cggtgcgtgg gcggccggtg gcgtcggcgc cccggacgag gaagacgccg
    13981 cagaaggcgg ggtagccctg gtcggtgtcg atggcgaagc cgggcaggag aatgtcgatc
    14041 gtcggcatgg aactcccttg tgtgtggctg ccgttgacgc tcgggcggcc ggtccggtgt
    14101 cagccgtcgg ccgcctcgtg gacggcggcg cgcagcgctt cgaggctgtg cgggttggcg
    14161 agcgtggaga ggtcgccgga tgggtcctgg gtgacgcagt cgcgcatcag gcggcgcatc
    14221 accttgccgg tgcgggtccg gggcagttcg ggcagggcga tcacgcggct gggccggaag
    14281 gcgggcccga gcgcgtcggc gacgcgggcg cggatccggt cggcttccgg cgcggagagc
    14341 gtcccgtgcg cgggcaccac gaagcaccac agcgcctcgc ccttcaccgg gtgcggcacc
    14401 ccgaccgccg ccgcctcggc cacggcgggg tccccgagcg cggcctcctc gacctcggcg
    14461 gggccgagcc gtttgcccgc caccttcatc acgtcgtcga ggcggccgtg cacgaaccac
    14521 tccccgtcgg accgggaggc gaggtcgccg tgggaccagc ggccgggcct gcggctgaag
    14581 taggtgtggg cgaaccgctc cggcgcgcgc cacaggcccc gggtcatgcc cggccaggac
    14641 tggcgcacca ccagttcgcc catctcgccc tcgcctacct cggcgccgtc cgcgtcctcg
    14701 atgaccgcgt cgatgccgag gcagggtccg gtgaagccgc acggcgtctg ggggacggtg
    14761 ggcgcggacg ccaggagcga accgcccacc tccgtaccgc cgctgatgtt gatgacgggg
    14821 cagcggccgc cgccgacctc gtggaagtac cagcgccagg cgtcctcggt ccagggctcg
    14881 ccggtggagc cgaggatccg cagccgggac gcggcggacc cgggcccggc ggtggtcatc
    14941 atcgcccgcg ccaggctggg cgagctgccg aagacggtga cccggtgctc gtccatgagc
//
