BGC0000140 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000140 (Streptomyces sp. 88-682)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	15,000	4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	PKS	100%

BGC0000140 - Region 1 - T1PKS

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Location: 1 - 15,000 nt. (total: 15,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 15,001
Label		BGC0000140

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000140	1.00	Polyketide	4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Streptomyces sp. 88-682
BGC0001219	0.28	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0001909	0.25	Polyketide	strobilurin A	Strobilurus tenacellus
BGC0000922	0.25	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1
BGC0001831	0.25	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000154	0.24	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001895	0.23	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0001976	0.23	Terpene	eupenifeldin	Phoma sp.
BGC0002000	0.23	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000863	0.22	Other	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000140	1.00	Polyketide	4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Streptomyces sp. 88-682
BGC0001219	0.62	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0001909	0.59	Polyketide	strobilurin A	Strobilurus tenacellus
BGC0000922	0.58	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1
BGC0001831	0.58	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000154	0.58	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001895	0.57	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0001976	0.56	Terpene	eupenifeldin	Phoma sp.
BGC0002000	0.56	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000863	0.55	Other	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12

Similar known gene clusters from MIBiG 4.0

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 15000:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

rkA

CAL_domain (37..472): pk

minowa: NH2

Prediction, score:

NH2: 164.5
fatty_acid: 36.5
shikimic_acid: 0.0
Acetyl-CoA: -0.4
AHBA: -0.4

rkC

PKS_AT (531..814): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 138.7
Methoxymalonyl-CoA: 83.1
Methylmalonyl-CoA: 72.1
inactive: 69.0
Propionyl-CoA: 49.1
Isobutyryl-CoA: 32.6
Ethylmalonyl-CoA: 29.4
CHC-CoA: 25.2
Acetyl-CoA: 20.9
2-Methylbutyryl-CoA: 20.8
fatty_acid: 18.3
Benzoyl-CoA: 15.4
trans-1,2-CPDA: 14.5
3-Methylbutyryl-CoA: -0.1