BGC0000141: rubradirin biosynthetic gene cluster from Streptomyces achromogenes subsp. rubradiris
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Location: 1 - 105,657 nt. (total: 105,657 nt).
This entry is originally from NCBI GenBank AJ871581.1.

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core biosynthetic genes
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transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000141
Short description rubradirin biosynthetic gene cluster from Streptomyces achromogenes subsp. rubradiris
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AJ871581.1
via Enzymatic assays
Compounds
  • rubradirin
Species Streptomyces achromogenes subsp. rubradiris [taxonomy]
References
Chemical products information
rubradirin Evidence:
Copy SMILES
C48H46N4O20
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAI94676.1
  • rubT1
 1 - 933 (-) putative ABC transporter
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    • CAI94677.1
    • rubN2
    		 1141 - 2157 (-) putative TDP-glucose dehydratase
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      • CAI94678.1
      		 2741 - 3502 (-) hypothetical protein
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        • CAI94679.1
        • rubR1
        		 4268 - 4492 (+) putative translation initiation factor
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          • CAI94680.1
          		 4625 - 5629 (-) hypothetical protein
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            • CAI94681.1
            • rubP6
            		 5775 - 7058 (+) cytochrome P450
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              • CAI94682.1
              • rubA
              		 7423 - 23472 (-) putative polyketide synthase
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                • CAI94683.1
                • rubR2
                		 23695 - 24459 (+) putative 30S ribosomal protein modification
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                  • CAI94684.1
                  • rubR3
                  		 24447 - 24671 (+) putative Translation initiation factor
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                    • CAI94685.1
                    		 24859 - 25854 (+) hypothetical protein
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                      • CAI94686.1
                      		 26018 - 27583 (+) hypothetical protein
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                        • CAI94687.1
                        		 27957 - 28952 (+) hypothetical protein
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                          • CAI94688.1
                          		 29116 - 29739 (+) hypothetical protein
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                            • CAI94689.1
                            • rubK
                            		 29902 - 31062 (+) putative AHBA synthase
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                              • CAI94690.1
                              • rubL
                              		 31059 - 32153 (+) putative oxidoreductase
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                                • CAI94691.1
                                • rubM
                                		 32153 - 32818 (+) putative phosphatase
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                                  • CAI94692.1
                                  • rubN
                                  		 32815 - 33738 (+) putative kinase
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                                    • CAI94693.1
                                    • rubG1
                                    		 33777 - 34709 (-) putative glycosyltransferase
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                                      • CAI94694.1
                                      • Rub7
                                      		 34797 - 38087 (-) hypothetical protein
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                                        • CAI94695.1
                                        		 38203 - 39045 (-) hypothetical protein
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                                          • CAI94696.1
                                          • rubN8
                                          		 39213 - 40484 (-) hypothetical protein
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                                            • CAI94697.1
                                            • rubN5
                                            		 40547 - 41782 (-) hypothetical protein
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                                              • CAI94698.1
                                              • rubN4
                                              		 41812 - 42933 (-) putative aminotransferase
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                                                • CAI94699.1
                                                • rubRg1
                                                		 43157 - 43957 (-) putative regulator
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                                                  • CAI94700.1
                                                  • rubF1
                                                  		 44495 - 45292 (+) hypothetical protein
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                                                    • CAI94701.1
                                                    • rubF2
                                                    		 45427 - 46269 (+) putative quinone oxidoreductase
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                                                      • CAI94702.1
                                                      • rubF
                                                      		 46312 - 47106 (+) putative amide synthase
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                                                        • CAI94703.1
                                                        • rubF3
                                                        		 47128 - 48414 (+) hypothetical protein
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                                                          • CAI94704.1
                                                          • rubF4
                                                          		 48466 - 49686 (-) putative cytochrome P450
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                                                            • CAI94705.1
                                                            • rubF5
                                                            		 49716 - 51389 (-) putative acid AMP ligase
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                                                              • CAI94706.1
                                                              • rubF6
                                                              		 51398 - 52987 (-) putative aminocoumarin ligase
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                                                                • CAI94707.1
                                                                • rubF7
                                                                		 53158 - 53814 (-) putative F420 dependent NADP reductase
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                                                                  • CAI94708.1
                                                                  • rubP3
                                                                  		 53822 - 54634 (-) putative Hydroxylase
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                                                                    • CAI94709.1
                                                                    		 54910 - 56058 (+) hypothetical protein
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                                                                      • CAI94710.1
                                                                      		 56826 - 57461 (-) hypothetical protein
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                                                                        • CAI94711.1
                                                                        • rubRg2
                                                                        		 58781 - 59782 (+) putative transcription regulator
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                                                                          • CAI94712.1
                                                                          		 59939 - 60694 (+) hypothetical protein
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                                                                            • CAI94713.1
                                                                            • rubB
                                                                            		 60687 - 75887 (-) putative polyketide synthase
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                                                                              • CAI94716.1
                                                                              • rubP1
                                                                              		 75929 - 77467 (-) putative hydroxyphenylpropionate
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                                                                                • CAI94718.1
                                                                                • rubC1
                                                                                		 77653 - 81606 (+) putative CoA ligase
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                                                                                  • CAI94719.1
                                                                                  • rubC2
                                                                                  		 81603 - 82832 (+) putative cytochrome P450
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                                                                                    • CAI94720.1
                                                                                    • rubC3
                                                                                    		 82829 - 83578 (+) putative oxyacyl-(acyl carrier protein) reductase
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                                                                                      • CAI94721.1
                                                                                      • rubJ
                                                                                      		 83661 - 84116 (+) putative aDHQ dehydratase
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                                                                                        • CAI94722.1
                                                                                        		 84130 - 84912 (+) hypothetical protein
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                                                                                          • CAI94723.1
                                                                                          • rubP4
                                                                                          		 85136 - 85948 (+) putative hydroxylase
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                                                                                            • CAI94724.1
                                                                                            • rubG
                                                                                            		 86106 - 87158 (+) putative aDHQ synthase
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                                                                                              • CAI94725.1
                                                                                              • rubH
                                                                                              		 87155 - 88378 (+) putative aDAHP synthase
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                                                                                                • CAI94726.1
                                                                                                • rubP2
                                                                                                		 88622 - 89824 (-) putative cytochrome P450
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                                                                                                  • CAI94727.1
                                                                                                  • rubG2
                                                                                                  		 89958 - 91154 (-) putative glycosyltransferase
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                                                                                                    • CAI94728.1
                                                                                                    • rubRg3
                                                                                                    		 91448 - 92320 (+) putative transcription activator
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                                                                                                      • CAI94729.1
                                                                                                      • rubN7
                                                                                                      		 92317 - 93243 (+) hypothetical protein
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                                                                                                        • CAI94730.1
                                                                                                        • rubN6
                                                                                                        		 93240 - 94229 (+) putative 4-Ketoreductase
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                                                                                                          • CAI94731.1
                                                                                                          • rubN3
                                                                                                          		 94240 - 95616 (-) putative TDP-glucose-2,3-dehydratase
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                                                                                                            • CAI94732.1
                                                                                                            • rubN1
                                                                                                            		 96035 - 97072 (-) putative TDP-glucose synthase
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                                                                                                              • CAI94733.1
                                                                                                              • rubP5
                                                                                                              		 97618 - 99207 (+) hypothetical protein
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                                                                                                                • CAI94734.1
                                                                                                                • rubC4
                                                                                                                		 99418 - 100098 (-) hypothetical protein
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                                                                                                                  • CAI94735.1
                                                                                                                  • rubC5
                                                                                                                  		 100355 - 101614 (-) putative secreted protein
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                                                                                                                    • CAI94736.1
                                                                                                                    • rubRg4
                                                                                                                    		 103001 - 105268 (-) putative transcription activator
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                                                                                                                      Biosynthesis information
                                                                                                                      Annotation changelog

                                                                                                                      Entry version: 4

                                                                                                                      Date
                                                                                                                      Changes
                                                                                                                      Submitters
                                                                                                                      Reviewers
                                                                                                                      2022-10-07
                                                                                                                      Update chemical activity to schema version 2.11
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                      Entry version: 3

                                                                                                                      Date
                                                                                                                      Changes
                                                                                                                      Submitters
                                                                                                                      Reviewers
                                                                                                                      2022-09-15
                                                                                                                      Updated bioactivity data
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      2022-09-15
                                                                                                                      Added AMP-binding domain substrate specificities
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                      Entry version: 2

                                                                                                                      Date
                                                                                                                      Changes
                                                                                                                      Submitters
                                                                                                                      Reviewers
                                                                                                                      2019-10-16
                                                                                                                      Migrated from v1.4
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                      Entry version: 1

                                                                                                                      Date
                                                                                                                      Changes
                                                                                                                      Submitters
                                                                                                                      Reviewers
                                                                                                                      2015-06-12
                                                                                                                      Submitted
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      Detailed domain annotation
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