BGC0000141: rubradirin biosynthetic gene cluster from Streptomyces achromogenes subsp. rubradiris
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Location: 1 - 105,657 nt. (total: 105,657 nt).
This entry is originally from NCBI GenBank AJ871581.1.

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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000141
Short description rubradirin biosynthetic gene cluster from Streptomyces achromogenes subsp. rubradiris
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AJ871581.1
Compounds
  • rubradirin
Species Streptomyces achromogenes subsp. rubradiris [taxonomy]
References
Chemical products information
rubradirin
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C48H46N4O20
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAI94676.1
  • rubT1
 1 - 933 (-) putative ABC transporter
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  • CAI94677.1
  • rubN2
 1141 - 2157 (-) putative TDP-glucose dehydratase
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  • CAI94678.1
 2741 - 3502 (-) hypothetical protein
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  • CAI94679.1
  • rubR1
 4268 - 4492 (+) putative translation initiation factor
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  • CAI94680.1
 4625 - 5629 (-) hypothetical protein
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  • CAI94681.1
  • rubP6
 5775 - 7058 (+) cytochrome P450
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  • CAI94682.1
  • rubA
 7423 - 23472 (-) putative polyketide synthase
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  • CAI94683.1
  • rubR2
 23695 - 24459 (+) putative 30S ribosomal protein modification
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  • CAI94684.1
  • rubR3
 24447 - 24671 (+) putative Translation initiation factor
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  • CAI94685.1
 24859 - 25854 (+) hypothetical protein
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  • CAI94686.1
 26018 - 27583 (+) hypothetical protein
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  • CAI94687.1
 27957 - 28952 (+) hypothetical protein
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  • CAI94688.1
 29116 - 29739 (+) hypothetical protein
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  • CAI94689.1
  • rubK
 29902 - 31062 (+) putative AHBA synthase
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  • CAI94690.1
  • rubL
 31059 - 32153 (+) putative oxidoreductase
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  • CAI94691.1
  • rubM
 32153 - 32818 (+) putative phosphatase
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  • CAI94692.1
  • rubN
 32815 - 33738 (+) putative kinase
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  • CAI94693.1
  • rubG1
 33777 - 34709 (-) putative glycosyltransferase
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  • CAI94694.1
  • Rub7
 34797 - 38087 (-) hypothetical protein
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  • CAI94695.1
 38203 - 39045 (-) hypothetical protein
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  • CAI94696.1
  • rubN8
 39213 - 40484 (-) hypothetical protein
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  • CAI94697.1
  • rubN5
 40547 - 41782 (-) hypothetical protein
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  • CAI94698.1
  • rubN4
 41812 - 42933 (-) putative aminotransferase
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  • CAI94699.1
  • rubRg1
 43157 - 43957 (-) putative regulator
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  • CAI94700.1
  • rubF1
 44495 - 45292 (+) hypothetical protein
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  • CAI94701.1
  • rubF2
 45427 - 46269 (+) putative quinone oxidoreductase
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  • CAI94702.1
  • rubF
 46312 - 47106 (+) putative amide synthase
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  • CAI94703.1
  • rubF3
 47128 - 48414 (+) hypothetical protein
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  • CAI94704.1
  • rubF4
 48466 - 49686 (-) putative cytochrome P450
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  • CAI94705.1
  • rubF5
 49716 - 51389 (-) putative acid AMP ligase
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  • CAI94706.1
  • rubF6
 51398 - 52987 (-) putative aminocoumarin ligase
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  • CAI94707.1
  • rubF7
 53158 - 53814 (-) putative F420 dependent NADP reductase
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  • CAI94708.1
  • rubP3
 53822 - 54634 (-) putative Hydroxylase
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  • CAI94709.1
 54910 - 56058 (+) hypothetical protein
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  • CAI94710.1
 56826 - 57461 (-) hypothetical protein
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  • CAI94711.1
  • rubRg2
 58781 - 59782 (+) putative transcription regulator
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  • CAI94712.1
 59939 - 60694 (+) hypothetical protein
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  • CAI94713.1
  • rubB
 60687 - 75887 (-) putative polyketide synthase
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  • CAI94716.1
  • rubP1
 75929 - 77467 (-) putative hydroxyphenylpropionate
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  • CAI94718.1
  • rubC1
 77653 - 81606 (+) putative CoA ligase
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  • CAI94719.1
  • rubC2
 81603 - 82832 (+) putative cytochrome P450
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  • CAI94720.1
  • rubC3
 82829 - 83578 (+) putative oxyacyl-(acyl carrier protein) reductase
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  • CAI94721.1
  • rubJ
 83661 - 84116 (+) putative aDHQ dehydratase
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  • CAI94722.1
 84130 - 84912 (+) hypothetical protein
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  • CAI94723.1
  • rubP4
 85136 - 85948 (+) putative hydroxylase
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  • CAI94724.1
  • rubG
 86106 - 87158 (+) putative aDHQ synthase
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  • CAI94725.1
  • rubH
 87155 - 88378 (+) putative aDAHP synthase
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  • CAI94726.1
  • rubP2
 88622 - 89824 (-) putative cytochrome P450
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  • CAI94727.1
  • rubG2
 89958 - 91154 (-) putative glycosyltransferase
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  • CAI94728.1
  • rubRg3
 91448 - 92320 (+) putative transcription activator
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  • CAI94729.1
  • rubN7
 92317 - 93243 (+) hypothetical protein
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  • CAI94730.1
  • rubN6
 93240 - 94229 (+) putative 4-Ketoreductase
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  • CAI94731.1
  • rubN3
 94240 - 95616 (-) putative TDP-glucose-2,3-dehydratase
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  • CAI94732.1
  • rubN1
 96035 - 97072 (-) putative TDP-glucose synthase
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  • CAI94733.1
  • rubP5
 97618 - 99207 (+) hypothetical protein
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  • CAI94734.1
  • rubC4
 99418 - 100098 (-) hypothetical protein
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  • CAI94735.1
  • rubC5
 100355 - 101614 (-) putative secreted protein
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  • CAI94736.1
  • rubRg4
 103001 - 105268 (-) putative transcription activator
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added AMP-binding domain substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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