BGC0000143 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000143 (Streptomyces albus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	25,809	salinomycin	PKS	100%

BGC0000143 - Region 1 - T1PKS

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Location: 1 - 25,809 nt. (total: 25,809 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,810
Label		BGC0000143

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000143	1.00	Polyketide	salinomycin	Streptomyces albus
BGC0000041	0.33	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001163	0.28	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001164	0.28	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001201	0.24	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001162	0.23	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161	0.23	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0002127	0.22	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001235	0.20	NRP, Polyketide	antalid	Polyangium spumosum
BGC0000122	0.20	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000143	1.00	Polyketide	salinomycin	Streptomyces albus
BGC0000041	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001163	0.62	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001164	0.61	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001201	0.57	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001162	0.56	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161	0.56	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0002127	0.55	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001235	0.53	NRP, Polyketide	antalid	Polyangium spumosum
BGC0000122	0.52	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25809:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (ohmal - ohmal)
Non-colinear ordering:: salA + ABG02264.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

salA

PKS_AT (689..970): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 223.2
inactive: 101.4
Methoxymalonyl-CoA: 63.3
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 28.8
Isobutyryl-CoA: 17.7
Acetyl-CoA: 17.4
Benzoyl-CoA: 16.9
2-Methylbutyryl-CoA: 13.4
Ethylmalonyl-CoA: 10.8
CHC-CoA: 10.6
fatty_acid: 9.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

ABG02264.1

PKS_AT (565..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.0
inactive: 94.2
Methoxymalonyl-CoA: 53.0
Methylmalonyl-CoA: 49.5
Propionyl-CoA: 20.9
Isobutyryl-CoA: 19.0
Acetyl-CoA: 18.1
Benzoyl-CoA: 18.0
2-Methylbutyryl-CoA: 9.9
Ethylmalonyl-CoA: 7.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2124..2406): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.1
inactive: 95.6
Methoxymalonyl-CoA: 63.2
Methylmalonyl-CoA: 61.9
Propionyl-CoA: 28.5
Acetyl-CoA: 19.5
Isobutyryl-CoA: 18.2
Benzoyl-CoA: 17.7
2-Methylbutyryl-CoA: 13.3
CHC-CoA: 12.8
Ethylmalonyl-CoA: 12.4
fatty_acid: 9.6
trans-1,2-CPDA: 8.9
3-Methylbutyryl-CoA: 0.0