BGC0000143 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000143 (Streptomyces albus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	25,809	High	salinomycin	PKS

BGC0000143 - Region 1 - T1PKS

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Location: 1 - 25,809 nt. (total: 25,809 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,810
Label		BGC0000143

Tailoring functions

Oxidoreductases: oxygenase

salC: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

salD: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Ligases: synthase

ABG02264.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

salA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000143.5	1.00	PKS	salinomycin	Streptomyces albus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000041.3	0.65	PKS	oronofacic acid	Pseudomonas syringae
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000143.5	1.00	PKS	salinomycin	Streptomyces albus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000041.3	0.65	PKS	oronofacic acid	Pseudomonas syringae
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25809:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (ohmal - ohmal)
Non-colinear ordering:: salA + ABG02264.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

salA: mal

PKS_AT (689..970): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 223.2
inactive: 101.4
Methoxymalonyl-CoA: 63.3
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 28.8
Isobutyryl-CoA: 17.7
Acetyl-CoA: 17.4
Benzoyl-CoA: 16.9
2-Methylbutyryl-CoA: 13.4
Ethylmalonyl-CoA: 10.8
CHC-CoA: 10.6
fatty_acid: 9.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

ABG02264.1: mal - mal

PKS_AT (565..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.0
inactive: 94.2
Methoxymalonyl-CoA: 53.0
Methylmalonyl-CoA: 49.5
Propionyl-CoA: 20.9
Isobutyryl-CoA: 19.0
Acetyl-CoA: 18.1
Benzoyl-CoA: 18.0
2-Methylbutyryl-CoA: 9.9
Ethylmalonyl-CoA: 7.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2124..2406): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.1
inactive: 95.6
Methoxymalonyl-CoA: 63.2
Methylmalonyl-CoA: 61.9
Propionyl-CoA: 28.5
Acetyl-CoA: 19.5
Isobutyryl-CoA: 18.2
Benzoyl-CoA: 17.7
2-Methylbutyryl-CoA: 13.3
CHC-CoA: 12.8
Ethylmalonyl-CoA: 12.4
fatty_acid: 9.6
trans-1,2-CPDA: 8.9
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor