BGC0000144: salinomycin biosynthetic gene cluster from Streptomyces albus
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Location: 1 - 127,961 nt. (total: 127,961 nt).
This entry is originally from NCBI GenBank JN033543.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0000144
Short description | salinomycin biosynthetic gene cluster from Streptomyces albus
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Type I)

Loci
JN033543.1
via Knock-out studies
Compounds

- salinomycin

Species Streptomyces albus [taxonomy]
References

- [1] Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211. Jiang C et al., Appl Environ Microbiol (2012) PMID:22156425

Chemical products information
salinomycin Evidence:
Copy SMILES
C42H70O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
AEZ53933.1 | 239 - 694 (-) | putative alkyl hydroperoxide reductase subunit C protein |  |  | copy AA seq copy Nt seq
AEZ53934.1 | 824 - 1201 (-) | putative membrane protein |  |  | copy AA seq copy Nt seq
AEZ53935.1 | 1418 - 1918 (+) | putative transcription regulator |  |  | copy AA seq copy Nt seq
AEZ53936.1 | 2137 - 2913 (+) | putative amidinotransferase |  |  | copy AA seq copy Nt seq
AEZ53937.1 | 2910 - 4139 (+) | putative ornithine aminotransferase |  |  | copy AA seq copy Nt seq
AEZ53938.1 | 4218 - 5267 (-) | putative zinc-binding dehydrogenase family oxidoreductase |  |  | copy AA seq copy Nt seq
AEZ53939.1 | 5560 - 7008 (+) | putative glucose-6-phosphate 1-dehydrogenase |  |  | copy AA seq copy Nt seq
AEZ53940.1 | 7005 - 8204 (+) | putative membrane protein |  |  | copy AA seq copy Nt seq
AEZ53941.1 | 8477 - 9460 (-) | putative regulatory protein |  |  | copy AA seq copy Nt seq
AEZ53942.1 | 10037 - 10519 (+) | putative transcriptional regulator |  |  | copy AA seq copy Nt seq
AEZ53943.1 | 10611 - 12329 (-) | putative 3-hydroxybutyryl-CoA dehydrogenase | Precursor biosynthesis | Knock-out | copy AA seq copy Nt seq
AEZ53944.1 | 12326 - 13354 (-) | putative 3-oxoacyl-(acyl-carrier-protein ) synthase III | Precursor biosynthesis | Knock-out | copy AA seq copy Nt seq
AEZ53945.1 slnA1 | 13658 - 28435 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53946.1 slnA2 | 28468 - 40221 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53947.1 slnA3 | 40244 - 48322 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53948.1 slnA4 | 48450 - 53378 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53949.1 slnA5 | 53431 - 64683 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53950.1 slnA6 | 64798 - 69105 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53951.1 slnA7 | 69148 - 74082 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53952.1 slnA8 | 74150 - 85324 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53953.1 slnA9 | 85352 - 92290 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AEZ53954.1 slnBI | 92379 - 92765 (+) | putative epoxide hydrolase |  |  | copy AA seq copy Nt seq
AEZ53955.1 slnDI | 92807 - 93604 (+) | putative thioesterase | Scaffold biosynthesis | Knock-out | copy AA seq copy Nt seq
AEZ53956.1 slnM | 93645 - 94460 (+) | putative O-methyltransferase-like protein |  |  | copy AA seq copy Nt seq
AEZ53957.1 slnE | 94655 - 94936 (-) | putative ferridoxin protein |  |  | copy AA seq copy Nt seq
AEZ53958.1 slnF | 94933 - 96156 (-) | putative cytochrome P450 | Tailoring | Knock-out | copy AA seq copy Nt seq
AEZ53959.1 slnTI | 96333 - 97292 (+) | putative ABC transporter ATP-binding protein |  |  | copy AA seq copy Nt seq
AEZ53960.1 slnTII | 97289 - 98929 (+) | putative antibiotic ABC transporter efflux pump |  |  | copy AA seq copy Nt seq
AEZ53961.1 slnBII | 99101 - 99550 (-) | putative epoxide hydrolase | Tailoring | Knock-out | copy AA seq copy Nt seq
AEZ53962.1 slnBIII | 99543 - 100004 (-) | putative epoxide hydrolase | Tailoring | Knock-out | copy AA seq copy Nt seq
AEZ53963.1 slnC | 100184 - 101638 (+) | epoxidase | Tailoring | Knock-out | copy AA seq copy Nt seq
AEZ53964.1 slnR | 102168 - 104888 (+) | putative transcriptional regulator | Regulation | Knock-out | copy AA seq copy Nt seq
AEZ53965.1 slnDII | 105116 - 105877 (+) | putative thioesterase | Scaffold biosynthesis | Knock-out | copy AA seq copy Nt seq
AEZ53966.1 | 106029 - 108617 (+) | putative peptide synthetase |  |  | copy AA seq copy Nt seq
AEZ53967.1 | 108679 - 108927 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AEZ53968.1 | 109104 - 111671 (-) | putative SARP family transcriptional regulator |  |  | copy AA seq copy Nt seq
AEZ53969.1 | 111987 - 113780 (+) | putative AMP-binding domain-containing protein |  |  | copy AA seq copy Nt seq
AEZ53970.1 | 113774 - 115492 (+) | putative acyl-CoA dehydrogenase |  |  | copy AA seq copy Nt seq
AEZ53971.1 | 115524 - 115814 (+) | putative peptide carrier protein |  |  | copy AA seq copy Nt seq
AEZ53972.1 | 115811 - 116650 (+) | putative 4'-phosphopantetheinyl transferase |  |  | copy AA seq copy Nt seq
AEZ53973.1 | 116675 - 117658 (-) | putative gamma-butyrolactone biosynthesis protein |  |  | copy AA seq copy Nt seq
AEZ53974.1 | 117832 - 118878 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AEZ53975.1 | 119021 - 120190 (-) | putative secreted protein |  |  | copy AA seq copy Nt seq
AEZ53976.1 | 120227 - 121783 (-) | putative beta-hexosaminidase |  |  | copy AA seq copy Nt seq
AEZ53977.1 | 121828 - 122730 (-) | putative sugar transporter membrane protein |  |  | copy AA seq copy Nt seq
AEZ53978.1 | 122727 - 123713 (-) | putative sugar transporter membrane protein |  |  | copy AA seq copy Nt seq
AEZ53979.1 | 123761 - 125026 (-) | putative sugar transporter sugar binding protein |  |  | copy AA seq copy Nt seq
AEZ53980.1 | 125286 - 126194 (-) | putative hydrolase |  |  | copy AA seq copy Nt seq
AEZ53981.1 | 126616 - 127455 (+) | putative transcriptional regulator |  |  | copy AA seq copy Nt seq

Biosynthesis information

#### Biosynthetic modules

Name
0
Type
pks-modular
Genes
slnA1
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
Name
1
Type
pks-modular
Genes
slnA1
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
Name
2
Type
pks-modular
Genes
slnA1
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
Name
3
Type
pks-modular
Genes
slnA2
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
Name
4
Type
pks-modular
Genes
slnA2
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
Name
5
Type
pks-modular
Genes
slnA3
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
Name
6
Type
pks-modular
Genes
slnA3
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
7
Type
pks-modular
Genes
slnA4
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
Name
8
Type
pks-modular
Genes
slnA5
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
Name
9
Type
pks-modular
Genes
slnA5
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
10
Type
pks-modular
Genes
slnA6
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
Name
11
Type
pks-modular
Genes
slnA7
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
12
Type
pks-modular
Genes
slnA8
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
13
Type
pks-modular
Genes
slnA8
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
Name
14
Type
pks-modular
Genes
slnA9
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
15
Type
pks-trans-at
Genes
slnA9
Substrates
Integrated Monomers
Domains
ketosynthase
Annotation changelog

#### Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Removed gene names of 'No gene ID'

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Removed duplicate gene name

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Updated bioactivity data

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted

- (ID: 67IIUGVPORSPZSAXSJ6T72RE)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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