Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000144.1:
Cluster 1Polyketide1127961

BGC0000144, salinomycin biosynthetic gene cluster from Streptomyces albus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: salinomycin
PubChem ID: 72370
SMILES string: Copy to clipboard
Molecular formula: C42H70O11
Average molecular mass: 751.011 Da
Molecular activity: Other
Molecular target: Na+, K+

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Polyether (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Modular polyketide synthases:
slnA1 (AEZ53945.1)
Module 0
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None
Module 1
AT specificity: Ethylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

slnA2 (AEZ53946.1)
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

slnA3 (AEZ53947.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None
Module 6
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

slnA4 (AEZ53948.1)
Module 7
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

slnA5 (AEZ53949.1)
Module 8
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 9
AT specificity: Ethylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

slnA6 (AEZ53950.1)
Module 10
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

slnA7 (AEZ53951.1)
Module 11
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

slnA8 (AEZ53952.1)
Module 12
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 13
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

slnA9 (AEZ53953.1)
Module 14
AT specificity: Ethylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 15
Scaffold-modifying domain: None

Gene cluster description

salinomycin (BGC0000144). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank JN033543. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Bai Linquan (Shanghai Jiaotong university)

Literature references

1. Jiang C et al. (2012) Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211. Appl Environ Microbiol 78(4):994-1003. doi: 10.1128/AEM.06701-11. Epub