BGC0000144: salinomycin biosynthetic gene cluster from Streptomyces albus
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Location: 1 - 127,961 nt. (total: 127,961 nt).
This entry is originally from NCBI GenBank JN033543.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000144
Short description salinomycin biosynthetic gene cluster from Streptomyces albus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
JN033543.1
via Knock-out studies
Compounds
  • salinomycin
Species Streptomyces albus [taxonomy]
References
Chemical products information
salinomycin Evidence:
Copy SMILES
C42H70O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEZ53933.1
 239 - 694 (-) putative alkyl hydroperoxide reductase subunit C protein
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    • AEZ53934.1
    		 824 - 1201 (-) putative membrane protein
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      • AEZ53935.1
      		 1418 - 1918 (+) putative transcription regulator
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        • AEZ53936.1
        		 2137 - 2913 (+) putative amidinotransferase
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          • AEZ53937.1
          		 2910 - 4139 (+) putative ornithine aminotransferase
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            • AEZ53938.1
            		 4218 - 5267 (-) putative zinc-binding dehydrogenase family oxidoreductase
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              • AEZ53939.1
              		 5560 - 7008 (+) putative glucose-6-phosphate 1-dehydrogenase
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                • AEZ53940.1
                		 7005 - 8204 (+) putative membrane protein
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                  • AEZ53941.1
                  		 8477 - 9460 (-) putative regulatory protein
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                    • AEZ53942.1
                    		 10037 - 10519 (+) putative transcriptional regulator
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                      • AEZ53943.1
                      		 10611 - 12329 (-) putative 3-hydroxybutyryl-CoA dehydrogenase
                      • Precursor biosynthesis
                      • Knock-out
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                      • AEZ53944.1
                      		 12326 - 13354 (-) putative 3-oxoacyl-(acyl-carrier-protein ) synthase III
                      • Precursor biosynthesis
                      • Knock-out
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                      • AEZ53945.1
                      • slnA1
                      		 13658 - 28435 (+) polyketide synthase
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                        • AEZ53946.1
                        • slnA2
                        		 28468 - 40221 (+) polyketide synthase
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                          • AEZ53947.1
                          • slnA3
                          		 40244 - 48322 (+) polyketide synthase
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                            • AEZ53948.1
                            • slnA4
                            		 48450 - 53378 (+) polyketide synthase
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                              • AEZ53949.1
                              • slnA5
                              		 53431 - 64683 (+) polyketide synthase
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                                • AEZ53950.1
                                • slnA6
                                		 64798 - 69105 (+) polyketide synthase
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                                  • AEZ53951.1
                                  • slnA7
                                  		 69148 - 74082 (+) polyketide synthase
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                                    • AEZ53952.1
                                    • slnA8
                                    		 74150 - 85324 (+) polyketide synthase
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                                      • AEZ53953.1
                                      • slnA9
                                      		 85352 - 92290 (+) polyketide synthase
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                                        • AEZ53954.1
                                        • slnBI
                                        		 92379 - 92765 (+) putative epoxide hydrolase
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                                          • AEZ53955.1
                                          • slnDI
                                          		 92807 - 93604 (+) putative thioesterase
                                          • Scaffold biosynthesis
                                          • Knock-out
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                                          • AEZ53956.1
                                          • slnM
                                          		 93645 - 94460 (+) putative O-methyltransferase-like protein
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                                            • AEZ53957.1
                                            • slnE
                                            		 94655 - 94936 (-) putative ferridoxin protein
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                                              • AEZ53958.1
                                              • slnF
                                              		 94933 - 96156 (-) putative cytochrome P450
                                              • Tailoring
                                              • Knock-out
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                                              • AEZ53959.1
                                              • slnTI
                                              		 96333 - 97292 (+) putative ABC transporter ATP-binding protein
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                                                • AEZ53960.1
                                                • slnTII
                                                		 97289 - 98929 (+) putative antibiotic ABC transporter efflux pump
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                                                  • AEZ53961.1
                                                  • slnBII
                                                  		 99101 - 99550 (-) putative epoxide hydrolase
                                                  • Tailoring
                                                  • Knock-out
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                                                  • AEZ53962.1
                                                  • slnBIII
                                                  		 99543 - 100004 (-) putative epoxide hydrolase
                                                  • Tailoring
                                                  • Knock-out
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                                                  • AEZ53963.1
                                                  • slnC
                                                  		 100184 - 101638 (+) epoxidase
                                                  • Tailoring
                                                  • Knock-out
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                                                  • AEZ53964.1
                                                  • slnR
                                                  		 102168 - 104888 (+) putative transcriptional regulator
                                                  • Regulation
                                                  • Knock-out
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                                                  • AEZ53965.1
                                                  • slnDII
                                                  		 105116 - 105877 (+) putative thioesterase
                                                  • Scaffold biosynthesis
                                                  • Knock-out
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                                                  • AEZ53966.1
                                                  		 106029 - 108617 (+) putative peptide synthetase
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                                                    • AEZ53967.1
                                                    		 108679 - 108927 (-) hypothetical protein
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                                                      • AEZ53968.1
                                                      		 109104 - 111671 (-) putative SARP family transcriptional regulator
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                                                        • AEZ53969.1
                                                        		 111987 - 113780 (+) putative AMP-binding domain-containing protein
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                                                          • AEZ53970.1
                                                          		 113774 - 115492 (+) putative acyl-CoA dehydrogenase
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                                                            • AEZ53971.1
                                                            		 115524 - 115814 (+) putative peptide carrier protein
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                                                              • AEZ53972.1
                                                              		 115811 - 116650 (+) putative 4'-phosphopantetheinyl transferase
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                                                                • AEZ53973.1
                                                                		 116675 - 117658 (-) putative gamma-butyrolactone biosynthesis protein
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                                                                  • AEZ53974.1
                                                                  		 117832 - 118878 (-) hypothetical protein
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                                                                    • AEZ53975.1
                                                                    		 119021 - 120190 (-) putative secreted protein
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                                                                      • AEZ53976.1
                                                                      		 120227 - 121783 (-) putative beta-hexosaminidase
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                                                                        • AEZ53977.1
                                                                        		 121828 - 122730 (-) putative sugar transporter membrane protein
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                                                                          • AEZ53978.1
                                                                          		 122727 - 123713 (-) putative sugar transporter membrane protein
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                                                                            • AEZ53979.1
                                                                            		 123761 - 125026 (-) putative sugar transporter sugar binding protein
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                                                                              • AEZ53980.1
                                                                              		 125286 - 126194 (-) putative hydrolase
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                                                                                • AEZ53981.1
                                                                                		 126616 - 127455 (+) putative transcriptional regulator
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                                                                                  Biosynthesis information

                                                                                  Biosynthetic modules

                                                                                  Name
                                                                                  0
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA1
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                                  Name
                                                                                  1
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA1
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  2
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA1
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  3
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA2
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  4
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA2
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  5
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA3
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                                  Name
                                                                                  6
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA3
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  7
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA4
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                                  Name
                                                                                  8
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA5
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  9
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA5
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  10
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA6
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
                                                                                  Name
                                                                                  11
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA7
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  12
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA8
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  13
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA8
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  14
                                                                                  Type
                                                                                  pks-modular
                                                                                  Genes
                                                                                  slnA9
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                  Name
                                                                                  15
                                                                                  Type
                                                                                  pks-trans-at
                                                                                  Genes
                                                                                  slnA9
                                                                                  Substrates
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  ketosynthase
                                                                                  Annotation changelog

                                                                                  Entry version: 4

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-10-07
                                                                                  Update chemical activity to schema version 2.11
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 3

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-09-15
                                                                                  Removed gene names of 'No gene ID'
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2022-09-15
                                                                                  Removed duplicate gene name
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2022-09-15
                                                                                  Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2022-09-15
                                                                                  Updated bioactivity data
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 2

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2019-10-16
                                                                                  Migrated from v1.4
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 1

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2015-06-12
                                                                                  Submitted
                                                                                  • (ID: 67IIUGVPORSPZSAXSJ6T72RE)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                                  Detailed domain annotation
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