BGC0000145: salinosporamide A biosynthetic gene cluster from Salinispora tropica
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Location: 1 - 32,637 nt. (total: 32,637 nt).
This entry is originally from NCBI GenBank EF397502.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000145
Short description salinosporamide A biosynthetic gene cluster from Salinispora tropica
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: EF397502.1
Compounds
  • salinosporamide A
Species Salinispora tropica [taxonomy]
References
Chemical products information
salinosporamide A
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C15H20Cl1N1O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABP73634.1
  • salU
 2 - 307 (+) SalU
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  • ABP73635.1
  • salT
 355 - 1158 (+) SalT
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  • ABP73636.1
  • salS
 1364 - 1819 (+) SalS
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  • ABP73637.1
  • salRIII
 2926 - 3948 (+) SalRIII
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  • ABP73638.1
  • salQ
 4754 - 8203 (-) SalQ
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  • ABP73639.1
  • salRII
 8587 - 9264 (+) SalRII
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  • ABP73640.1
  • salO
 9296 - 10129 (-) SalO
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  • ABP73641.1
  • salN
 10134 - 10913 (-) SalN
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  • ABP73642.1
  • salM
 11151 - 11918 (+) SalM
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  • ABP73643.1
  • salL
 12058 - 12909 (+) SalL
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  • ABP73644.1
  • salK
 13250 - 14095 (-) SalK
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  • ABP73645.1
  • salA
 14478 - 20639 (+) SalA
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  • ABP73646.1
  • salB
 20636 - 22534 (+) SalB
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  • ABP73647.1
  • salC
 22531 - 24324 (+) SalC
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  • ABP73648.1
  • salD
 24345 - 25598 (+) SalD
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  • ABP73649.1
  • salE
 25604 - 25819 (+) SalE
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  • ABP73650.1
  • salF
 25819 - 26679 (+) SalF
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  • ABP73651.1
  • salG
 26667 - 28049 (+) SalG
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  • ABP73652.1
  • salH
 28033 - 29811 (+) SalH
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  • ABP73653.1
  • salI
 30256 - 31092 (-) SalI
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  • ABP73654.1
  • salJ
 32338 - >32637 (+) SalJ
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
salB
Module ?
Specificity: 3S-cyclohex-2-enylalanine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: CUSGWVK3I4TVHJH7NHPFAP2L, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added missing NRP class
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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