LOCUS       BGC0000146             21000 bp    DNA     linear   PLN 24-JUN-2010
DEFINITION  Alternaria solani solanapyrone biosynthetic gene cluster (sol6,
            sol5, sol4, sol3, sol2, sol1), complete cds.
ACCESSION   BGC0000146
VERSION     BGC0000146
KEYWORDS    .
SOURCE      Alternaria solani
  ORGANISM  Alternaria solani
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
            Pleosporaceae; Alternaria; Alternaria sect. Porri.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 12:59:34
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21000
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..21000
                     /db_xref="taxon:48100"
                     /mol_type="genomic DNA"
                     /organism="Alternaria solani"
     protocluster    1..21000
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[12519:20637]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      12520..20637
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..21000
                     /SMILES="C([*])C(-O)(C)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..21000
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000146"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21000
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(755..2411)
                     /gene="sol6"
     CDS             complement(join(755..958,1012..1122,1183..1533,1642..2141,
                     2192..2411))
                     /codon_start=1
                     /gene="sol6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 243.9; E-value: 5.5e-74)"
                     /gene_kind="biosynthetic-additional"
                     /product="P450"
                     /protein_id="BAJ09784.1"
                     /sec_met_domain="p450 (E-value: 2.5e-56, bitscore: 179.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFVPSNIGWLVLSCGLFVAYWVLLAIYRLHFHPLSRYRGPRVAAV
                     SNSWYEWYWNYYLNGQMIFEIQRLHKQYGPVVRIGVNDLSIDDPEVYQAMTKVSSGFTK
                     DPHFYRCISFPGTSIGETDPAQSRIRRKVLTPALSGTRVQELAPAILVKVERLLRRVDL
                     CAQSAKTICITSACKALTMDIISKIVLGREIGCIEEPDFRNSFIENLNAAFETGWIATA
                     FPRLATLALWMASMSDFSSYLEVFDPHSAVYVAREDVNVPSAIAAHADRSAVIDMLMDP
                     LTVKGHTVPSLEQLNDEAVILLTAGNDTTSNSMIFGLYQICNNMSVYKTLFQELQGHFP
                     SVDQQITYEEAKQLPYLTATIKEILRLGTPLPGRLPRLIPSSGFQLYGQDLPPKTSIHT
                     SPYLXNRHPSIWDNPNDFNPDRWLRKNSRDLDKYLATFNRGARQCLGKEWVHSYQIAGL
                     WQD"
     gene            3092..4841
                     /gene="sol5"
     CDS             join(3092..3351,3404..3735,3787..3939,3987..4520,
                     4573..4841)
                     /codon_start=1
                     /gene="sol5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 182.7;
                     E-value: 3e-55)"
                     /gene_kind="biosynthetic-additional"
                     /product="oxidase/Diels-Alderase"
                     /protein_id="BAJ09785.1"
                     /transl_table=11
                     /translation="MRLIILNLLSLGITPSVVGHSGPHRQETQNLNNFLESNAINPAAI
                     NGETRHTGGVHLACAILEASNQTAVVFPSDGELYTQIDKAHASATAPKNPACIYTPNDV
                     KGVSLGVKVATFVQAKFAIRSGGHSPMEYFANIDGGVLISLAGIKTLEYNADTQTQRSG
                     FGNLWQDVYRHVNAQGRTVVGGRTGSVGLALTLGGGLSHFSNAYGWAAQNVLSYEMVLA
                     DGSIVIASEEENSDLYFAVKAGANNFGIVTHIVQRTYPLGKIWGGSMIFPGNASAQFMA
                     ALADYQAKGQLDKKSAILPYVGLIADAVVAQFSYLEPVERPEAFEAFYDIPVIQDLTQV
                     WDTFAAMVTAPIPYNMTRFSYATTDLLYDKEAYLEIERICHKYIPRMRKLEGGDIMLMP
                     QPISVSMVGEARARGSDPMGVADQPQLWFVVSSGWNLAQDDAEAESIMLDALAEVEEYT
                     KSRALHLPFYFLNDAFSTQMPLQSYGAVTYGKLQAASRKYDPTRVFQELVPGGFKLV"
     gene            6070..7810
                     /gene="sol4"
     CDS             join(6070..6632,6700..7810)
                     /codon_start=1
                     /gene="sol4"
                     /product="trascription factor"
                     /protein_id="BAJ09786.1"
                     /transl_table=11
                     /translation="MPSTLIHDVQKELKDLPARGIVDFLIQYFFEDINWINQIVHPPRL
                     LAQYENWWKMDTITRVADLEFAVLMLRICAYASHFLPSKKYTVDTIKGRPLSDIRSNCD
                     RLAGRLEGICNAAVLRGSLVRVQYMAFTAMCYECDSRIKLSWDTLCCAIREAQEVGLHR
                     EPPMRGDDGMDDLEREMRRRMFCNLRLAKALDRVPFLVDAYCTVSLPQMHLHPTIANLQ
                     APDLFTERVLQAQLVRFWKKLEAVNGPPGARPYDPVIAEERYQRFCNEFLPELPAPFAL
                     EPNTDWDQHIPELPRQRELFHVALFESVMHNFRQLLRLDQHHLRSLPNSRMALVTQHRH
                     TLATAAMGLFQSVTSLHAMMSFNQTKLSLVIFYHFEMAVVLSLCIIRACDSNGMQDLEH
                     INFFSPHSPLSSNMIDISQSQCLRTIKEARRQLEMMSLGSVMAETGARQLGILVDHVQA
                     TLARSGTQTRSMPSTETLTYNSSSSTSYGDGHAHGVSSELPFTFQQQEGPTANAFRTDS
                     NVFEGLMLWDLSTDALPLDPSFLGLEQLHEISELQPNMGL"
     gene            8294..9202
                     /gene="sol3"
     CDS             join(8294..8692,8744..9202)
                     /codon_start=1
                     /gene="sol3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     94.9; E-value: 9.4e-29)"
                     /gene_kind="biosynthetic-additional"
                     /product="dehydrogenase"
                     /protein_id="BAJ09787.1"
                     /transl_table=11
                     /translation="MGGMLGFFVRQLTFMPKPLPQNVRLDGKTAIVTGANVGLGLEASK
                     EMASHGLARVILGVRTVSKGEAAKQEILKQSPNCDVQVWPVDHESFESMVAFGERAQSL
                     DRLDIVILCAGVKNLVFSLSKTGHEQNVQVNHLGTSLLSLLLLKPLKDTAAKTGSPSRL
                     TIVASEVHFWTPFDERKAPSILARLDEKDSFRGMERYNTSKLLNILWMRELSSRVTGNV
                     VINAVNPGLCASALHRTDPTPGLAYLNKIFAWTPAQGGHNLTYAATQHVDEPGAYLSEQ
                     HLEK"
     gene            complement(9732..11221)
                     /gene="sol2"
     CDS             complement(join(9732..10208,10287..10396,10463..10632,
                     10695..11221))
                     /codon_start=1
                     /gene="sol2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 242; E-value:
                     1.7e-73)"
                     /gene_kind="biosynthetic-additional"
                     /product="O-methyltransferase"
                     /protein_id="BAJ09788.1"
                     /transl_table=11
                     /translation="MALKSTNGTHAGPTASAASLASLAANISEKAASLSTYLESQGHAQ
                     PSFLPGCADPPETEEYLALHTSLTSSLEDLQRLVDGPRRSLRPFIMIGNDLAALQVAFD
                     FGFFQLIPPEGSMDVETLAHKVGIDADRTARVLRMLATHRIFVEPKPGFFAHTAASAVF
                     HDDEELRCAGHYMLDECFKAATACSDCIKASPNDSDSTHSPFNTYFGVPMFSYYEQNPQ
                     FAARFAKAMAVDRQIAELRDCFPWGDIKGTVVDVGGGSGHISMALARNFPKLDFIVQDD
                     SEKMLAQGRARNLSDIEGRISFMKHSFFHPQPIGGAGAFFIRQCTHNWCDRDVVKILKS
                     FVPGLENSAPGTPLLINDTVLPVPGSKPLHEERALRQMDMLMFVVLGAKQRTAKEFEAL
                     LKEADARYEIRRVHADGSMGLVEVHLNI"
     gene            12520..20637
                     /gene="sol1"
     CDS             join(12520..12586,12639..13110,13197..19620,19675..20637)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (16-440). E-value:
                     6.8e-160. Score: 524.4. Matches aSDomain:
                     nrpspksdomains_sol1_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (619-934). E-value: 6.2e-87.
                     Score: 283.6. Matches aSDomain:
                     nrpspksdomains_sol1_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (1010-1187). E-value: 1.8e-28.
                     Score: 91.8. Matches aSDomain:
                     nrpspksdomains_sol1_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1493-1666). E-value: 4e-60. Score:
                     194.9. Matches aSDomain: nrpspksdomains_sol1_cMT.1"
                     /NRPS_PKS="Domain: PKS_ER (1893-2206). E-value: 3e-84.
                     Score: 274.6. Matches aSDomain:
                     nrpspksdomains_sol1_PKS_ER.1"
                     /NRPS_PKS="Domain: PKS_KR (2230-2408). E-value: 1.7e-46.
                     Score: 150.3. Matches aSDomain:
                     nrpspksdomains_sol1_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2556-2626). E-value: 6.7e-14.
                     Score: 43.9. Matches aSDomain:
                     nrpspksdomains_sol1_PKS_PP.1"
                     /codon_start=1
                     /gene="sol1"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 228.8; E-value:
                     2e-69)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="BAJ09789.1"
                     /sec_met_domain="itr_KS (E-value: 3.3e-165, bitscore:
                     538.6, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 6.6e-88, bitscore: 283.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 9.3e-17, bitscore:
                     50.0, seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 8.7e-42, bitscore:
                     131.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-09, bitscore:
                     25.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQYGTNGASADPEPIAIVGMGCRWPGGVRDASSLWELLKNKRS
                     GYREFGDHRFSRKGFHHPNSEHPGTVATEGGFLLAEDPRLFDHAFFGIGSLEVETMDPS
                     QRKLLEVVYEAFENSGEPWDSFSGSTTGVFVGNFSSDHLIIQGRDTDHPRPYASVGTGT
                     SILSNRVNYIFNLRGPSVTIDTACSSSMYALHLAISAIRNGDCDSAIVAASNTIIDPST
                     XLMMTKLGVLSPTSTSHTFDSSADGYARGEGFSALYLKRMSTAVDGDYPIRALVRGSAL
                     NANGRTGGITHPGREGQEAVIRKAYENAGNLPMKDTTFFECHGTGTPVGDPIEISAIGN
                     VFGSATTPEKPLLVGSIKTNIGHTEPASAIAGIMKVVLALENGFIPPSIGIKKLNPKLD
                     LKGGRINILTENTPWPDGRVRRASVNSFGYGGANGHCIIDDVRTVLPDYKKRTANTSIG
                     HINGHTNGHTNGHTNGHTNGHTNGHTNGHTNGAHASDGHNGHHQNGMNGNSASHMSEKA
                     DKVHYPFSYKPTLVKDFNAKPRRRVLIPFSAHNEASLDLNITAISEAIKRENLADVAYT
                     LAAKRSRFMQRTFRIVDSESPANGFAVKEKVLASGTQTARLGFVFTGQGAQWHAMGADL
                     FEYAVFRTSIEYLDSILASLPTPSAWKIEDILAGNCDPNDIHKPEVSQTVCTAVQIGLV
                     DLLYTWNVRPSAAVGHSSGEIAATYAAGRITAAQAIAAAYFRGQAVSKNKSKGLMLAVG
                     LGLDKAEAYISGLDSSVRIAAINSPDSVTLSGDESTIKDVAAKLNEDKVFNRELKTGGN
                     AYHSHHMLALGEFYNSTLSEGLDYVKSLGQAEPSQLYATRPWMSSVYPSKSTENPPVSP
                     SYWRANLESPVRFSEALANMLNLPDPIDVLVEIGPHPALKGPVGQISRSVDKSLPYFPT
                     LNRGTNGGISLLQLAGSLFSLNAEVDLTAVNAVDVISANQLKLVHGTTATNLPPYQYAY
                     GPVIYHESRFSKEFRGRDIVRHDLLGSKLPGNAKLRPQWRNILRLKDLPWLNDHKLLPY
                     PVFPAAGYIATVIEAASRIYNEQSEPLDITGYKLRNVTFSSAMRLPDDDFGLEIITSLE
                     LADAANPKAPTWATFSISSVAREAGTWTEHCSGRVRVIAGTSVANEKMSTEMDARTLDT
                     KAWYKKFAEIGLGYGPTFQPLSNIRADPSKGLAVAQLALHTTRDTVEGGESNYPLHPAS
                     LDAVFQLSLVASHGGQIDRVCNAFVPVHIDQLYVRNGVSQDSAVAIALGSMKGLRSAHA
                     KLQVLDKSEQVVLDVGNLRCVTYTEVLPSTGADKEAFSIPFLRLSWKPDIRAMDNEQVQ
                     RRFPPPTENVEKAYLFDKLERLGTLYVAEIHERYAGQGQFSSAPAHIDNFLSWVRRRMK
                     DDNKWVAEANSLTSSQRGILIKELFAEVGHISDVKIANKVFNNMEDILNERKTGLEVVI
                     PDNLLHGMYEDGLIMTGAYPQLVRFFDLFGYANPNMRILEIGAGTGGATRKILKTLIGP
                     HGIKRYQDYTFTDISSGFLAQAREAFADFQDMKYSVLDIQENPLEHGYEAVYDVVVACE
                     CLHATPSIVKTLTNCRKLVKPGGRLVVVENTRAVIGHGLVLGHLSGYWDGIPDGRVESP
                     FLHLEGWNASLNQTGFAGAELVLDDYPAPYTTARTIVSSAVEEPAKVGQSPNGTVHLVH
                     GDNRPELLSRIEHELTERGTEFKVISIGDVETHLPDNSRTVAFADSKSLLVNASENDLK
                     SFKALIRKSANLVWVTFGGIVHGHDPDASITTGLLRTLGTENPASQFLSIDVSPDSDFQ
                     EIRLTRTILDQELALSDRIAGESRDYEFVWQEDCLWVSRLVPDVALQDKLELSESRPSR
                     AEMLPLDSQGSVQAAFETPGLLTSLYFKPYEETWKSLPDDWIQVKVAAVGLNWKDLLTS
                     AGRFDMNTFSSEYSGVVAQVGLNVTNVAVGDRVYGYGRGHFGNYVRAPANFAYRMLPGE
                     DFVKMATIPLVGMTAIYSFECVTQLKDQERLLIQSATGGLGLSAIQLAKAKGAEIFATA
                     GTQEKRRYLIDVVGIPASHVFSSRDPADFAKLMEATDGKGFNVILSTSSGELLYDSIKM
                     LAPMGRIIDVGRIDVQNSTSLALELFKRNATFTSFDLAVADDADRALGPALMKAVNKRV
                     RAGQMGPLSSITTYDVSQLDQALMAFSKGTHVGKLVVTFQNPDALVKMVPAAPHAQFAR
                     NANYLITGGLGGLGRSIVNFMAERGARHFTVLSRSRKINSEGQMLIDKLATSGTVVECV
                     SCDVSDSKDVARAVQDAAVVRPIKGIVHAAVSYQDLSFDKLAIEQWTSALAAKVQGTKN
                     LHEATKTHALDFFLMTTTIESFVALATQSAYTAANNFQDYFARWRRQQGLPASTVSFGL
                     IRDVGHLSTNSTTLALMARNKVMDISEYNFLRLLEPAFLNNESALDPAASKEPYTGAVD
                     DPLSVTNVVTCFDPATMATRKREEAAENNGNTGNSPRWYTDARVSLIMRAFDDAERYQA
                     SAGGGGDGGNERGNNAGVASLRSEFGEAVKAGPAERSRTVALVTDAIVKTVAQMLFVDA
                     SGVDASRTVADYGVDSLIAAELRNWFNVAFGADVSMLEMLDTATSMKILANKIVDGALA
                     "
     aSDomain        join(12568..12586,12639..13110,13197..13977)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sol1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.80E-160"
                     /label="sol1_PKS_KS.1"
                     /locus_tag="sol1"
                     /protein_end="440"
                     /protein_start="16"
                     /score="524.4"
                     /tool="antismash"
                     /translation="IAIVGMGCRWPGGVRDASSLWELLKNKRSGYREFGDHRFSRKGFH
                     HPNSEHPGTVATEGGFLLAEDPRLFDHAFFGIGSLEVETMDPSQRKLLEVVYEAFENSG
                     EPWDSFSGSTTGVFVGNFSSDHLIIQGRDTDHPRPYASVGTGTSILSNRVNYIFNLRGP
                     SVTIDTACSSSMYALHLAISAIRNGDCDSAIVAASNTIIDPSTXLMMTKLGVLSPTSTS
                     HTFDSSADGYARGEGFSALYLKRMSTAVDGDYPIRALVRGSALNANGRTGGITHPGREG
                     QEAVIRKAYENAGNLPMKDTTFFECHGTGTPVGDPIEISAIGNVFGSATTPEKPLLVGS
                     IKTNIGHTEPASAIAGIMKVVLALENGFIPPSIGIKKLNPKLDLKGGRINILTENTPWP
                     DGRVRRASVNSFGYGGANGHCIIDD"
     aSModule        12568..20589
                     /complete
                     /domains="nrpspksdomains_sol1_PKS_KS.1"
                     /domains="nrpspksdomains_sol1_PKS_AT.1"
                     /domains="nrpspksdomains_sol1_PKS_DH.1"
                     /domains="nrpspksdomains_sol1_cMT.1"
                     /domains="nrpspksdomains_sol1_PKS_ER.1"
                     /domains="nrpspksdomains_sol1_PKS_KR.1"
                     /domains="nrpspksdomains_sol1_PKS_PP.1"
                     /iterative
                     /locus_tags="sol1"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       join(13103..13110,13197..13236)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0001"
                     /evalue="2.30E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="sol1"
                     /protein_end="193"
                     /protein_start="177"
                     /score="19.6"
                     /tool="antismash"
                     /translation="GPSVTIDTACSSSMYA"
     CDS_motif       13378..13416
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0002"
                     /evalue="5.30E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="sol1"
                     /protein_end="253"
                     /protein_start="240"
                     /score="13.1"
                     /tool="antismash"
                     /translation="FDSSADGYARGEG"
     CDS_motif       13615..13659
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0003"
                     /evalue="6.00E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="sol1"
                     /protein_end="334"
                     /protein_start="319"
                     /score="12.1"
                     /tool="antismash"
                     /translation="FECHGTGTPVGDPIE"
     CDS_motif       13675..13707
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0004"
                     /evalue="4.30E+01"
                     /label="PKSI-ER_m6"
                     /locus_tag="sol1"
                     /protein_end="350"
                     /protein_start="339"
                     /score="-2.2"
                     /tool="antismash"
                     /translation="NVFGSATTPEK"
     CDS_motif       13720..13761
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0005"
                     /evalue="1.10E-02"
                     /label="PKSI-KS_m6"
                     /locus_tag="sol1"
                     /protein_end="368"
                     /protein_start="354"
                     /score="8.8"
                     /tool="antismash"
                     /translation="GSIKTNIGHTEPAS"
     CDS_motif       14512..14562
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0006"
                     /evalue="2.10E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="sol1"
                     /protein_end="635"
                     /protein_start="618"
                     /score="17.0"
                     /tool="antismash"
                     /translation="FVFTGQGAQWHAMGADL"
     aSDomain        14515..15459
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sol1_PKS_AT.1"
                     /evalue="6.20E-87"
                     /label="sol1_PKS_AT.1"
                     /locus_tag="sol1"
                     /protein_end="934"
                     /protein_start="619"
                     /score="283.6"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFTGQGAQWHAMGADLFEYAVFRTSIEYLDSILASLPTPSAWKIE
                     DILAGNCDPNDIHKPEVSQTVCTAVQIGLVDLLYTWNVRPSAAVGHSSGEIAATYAAGR
                     ITAAQAIAAAYFRGQAVSKNKSKGLMLAVGLGLDKAEAYISGLDSSVRIAAINSPDSVT
                     LSGDESTIKDVAAKLNEDKVFNRELKTGGNAYHSHHMLALGEFYNSTLSEGLDYVKSLG
                     QAEPSQLYATRPWMSSVYPSKSTENPPVSPSYWRANLESPVRFSEALANMLNLPDPIDV
                     LVEIGPHPALKGPVGQISRSVDKSLPYFPTLNRG"
     CDS_motif       14761..14847
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0007"
                     /evalue="4.50E-07"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="sol1"
                     /protein_end="730"
                     /protein_start="701"
                     /score="22.5"
                     /tool="antismash"
                     /translation="VRPSAAVGHSSGEIAATYAAGRITAAQAI"
     aSDomain        15688..16218
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sol1_PKS_DH.1"
                     /evalue="1.80E-28"
                     /label="sol1_PKS_DH.1"
                     /locus_tag="sol1"
                     /protein_end="1187"
                     /protein_start="1010"
                     /score="91.8"
                     /tool="antismash"
                     /translation="HDLLGSKLPGNAKLRPQWRNILRLKDLPWLNDHKLLPYPVFPAAG
                     YIATVIEAASRIYNEQSEPLDITGYKLRNVTFSSAMRLPDDDFGLEIITSLELADAANP
                     KAPTWATFSISSVAREAGTWTEHCSGRVRVIAGTSVANEKMSTEMDARTLDTKAWYKKF
                     AEIGLGYGPTFQPL"
     CDS_motif       15772..15849
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0008"
                     /evalue="4.90E-08"
                     /label="PKSI-DH_m2"
                     /locus_tag="sol1"
                     /protein_end="1064"
                     /protein_start="1038"
                     /score="25.5"
                     /tool="antismash"
                     /translation="WLNDHKLLPYPVFPAAGYIATVIEAA"
     aSDomain        17137..17655
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sol1_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="4.00E-60"
                     /label="sol1_cMT.1"
                     /locus_tag="sol1"
                     /protein_end="1666"
                     /protein_start="1493"
                     /score="194.9"
                     /tool="antismash"
                     /translation="NPNMRILEIGAGTGGATRKILKTLIGPHGIKRYQDYTFTDISSGF
                     LAQAREAFADFQDMKYSVLDIQENPLEHGYEAVYDVVVACECLHATPSIVKTLTNCRKL
                     VKPGGRLVVVENTRAVIGHGLVLGHLSGYWDGIPDGRVESPFLHLEGWNASLNQTGFAG
                     AELVLDDYPA"
     aSDomain        18337..19275
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sol1_PKS_ER.1"
                     /evalue="3.00E-84"
                     /label="sol1_PKS_ER.1"
                     /locus_tag="sol1"
                     /protein_end="2206"
                     /protein_start="1893"
                     /score="274.6"
                     /tool="antismash"
                     /translation="GLLTSLYFKPYEETWKSLPDDWIQVKVAAVGLNWKDLLTSAGRFD
                     MNTFSSEYSGVVAQVGLNVTNVAVGDRVYGYGRGHFGNYVRAPANFAYRMLPGEDFVKM
                     ATIPLVGMTAIYSFECVTQLKDQERLLIQSATGGLGLSAIQLAKAKGAEIFATAGTQEK
                     RRYLIDVVGIPASHVFSSRDPADFAKLMEATDGKGFNVILSTSSGELLYDSIKMLAPMG
                     RIIDVGRIDVQNSTSLALELFKRNATFTSFDLAVADDADRALGPALMKAVNKRVRAGQM
                     GPLSSITTYDVSQLDQALMAFSKGTHVGKLVV"
     CDS_motif       18718..18777
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0009"
                     /evalue="5.50E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="sol1"
                     /protein_end="2040"
                     /protein_start="2020"
                     /score="22.1"
                     /tool="antismash"
                     /translation="ERLLIQSATGGLGLSAIQLA"
     CDS_motif       18787..18837
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0010"
                     /evalue="1.80E-07"
                     /label="PKSI-ER_m6"
                     /locus_tag="sol1"
                     /protein_end="2060"
                     /protein_start="2043"
                     /score="23.5"
                     /tool="antismash"
                     /translation="GAEIFATAGTQEKRRYL"
     aSDomain        join(19348..19620,19675..19935)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sol1_PKS_KR.1"
                     /evalue="1.70E-46"
                     /label="sol1_PKS_KR.1"
                     /locus_tag="sol1"
                     /protein_end="2408"
                     /protein_start="2230"
                     /score="150.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="NYLITGGLGGLGRSIVNFMAERGARHFTVLSRSRKINSEGQMLID
                     KLATSGTVVECVSCDVSDSKDVARAVQDAAVVRPIKGIVHAAVSYQDLSFDKLAIEQWT
                     SALAAKVQGTKNLHEATKTHALDFFLMTTTIESFVALATQSAYTAANNFQDYFARWRRQ
                     QGLPASTVSFGLIRD"
     CDS_motif       19351..19446
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0011"
                     /evalue="5.50E-15"
                     /label="PKSI-KR_m1"
                     /locus_tag="sol1"
                     /protein_end="2263"
                     /protein_start="2231"
                     /score="47.9"
                     /tool="antismash"
                     /translation="YLITGGLGGLGRSIVNFMAERGARHFTVLSRS"
     CDS_motif       19777..19887
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sol1_0012"
                     /evalue="6.80E-12"
                     /label="PKSI-KR_m4"
                     /locus_tag="sol1"
                     /protein_end="2392"
                     /protein_start="2355"
                     /score="37.9"
                     /tool="antismash"
                     /translation="LDFFLMTTTIESFVALATQSAYTAANNFQDYFARWRR"
     aSDomain        20380..20589
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sol1_PKS_PP.1"
                     /evalue="6.70E-14"
                     /label="sol1_PKS_PP.1"
                     /locus_tag="sol1"
                     /protein_end="2626"
                     /protein_start="2556"
                     /score="43.9"
                     /tool="antismash"
                     /translation="AERSRTVALVTDAIVKTVAQMLFVDASGVDASRTVADYGVDSLIA
                     AELRNWFNVAFGADVSMLEMLDTAT"
ORIGIN
        1 atcaacagtg cttgcgactc ctgaggcaag ggtttgcaca cggatctgcg cttcagaagc
       61 gcctaccaac tgtggtgaag gatgggtatg ttgatcgagc ttccatacaa gattgagtat
      121 ctgctaatcg gcggtaggaa cctgcgcgac tcggcgtaag taccgagcga cttgcaggat
      181 cgtggtgatg ctctcgagtt ctaagctgac atgtgcagga ttgttgggct tgctgccgga
      241 tttaggagct tttgcgatga agggatatag acggtgatcg aataacgttc ttggaagact
      301 aagtgaagtc ttgaaataat agtcggaata cgagctagcc taagataacg aggaggagaa
      361 cgcaatgtac gccgcgcatc tggtcaatgt gctcccatgt catcgatccc caagtcctaa
      421 tcttcgccgc gttcaccaat gttcagaact agcccatcaa gaagattcgg gagatcgcgt
      481 ttgtgtagct acacgaagat tccagacatg ttaaccttct aattgccttc taatccgccc
      541 ttttctcaac ctctgcgcac aggttatcct caaacctaag cctctcttag tacccgtaca
      601 gcgaacgcac attgtcactc ggatactcac tttaccaaga tcaaatcccg ccattgcata
      661 ttcgctggta gcgtcttgat atgataccgg cgaaacaagt tcgcgaagaa gacccagagt
      721 tcgcaccacg caagactaga catcgcatca attactaatc ttgccacaag cctgcgattt
      781 gataggagtg tacccactcc ttgccgagac attgcctcgc acccctgttg aaggttgcaa
      841 gatacttgtc caggtctcgg gaattcttcc ttagccatct gtcagggttg aagtcgtttg
      901 ggttatccca gatgctggga tggcgattga ntaggtaggg cgatgtatgg atgctcgtct
      961 gttggtgcgt cagctgtgtg ggatgcaagg tgggttgagg aaccacctta ctttcggagg
     1021 caggtcctga ccgtanagtt gaaaaccgga agatgggatc aagcgtggga gacgaccagg
     1081 tagaggggta ccgagtcgta agatctcttt gatggtagct gtctgtacac acgacgtggt
     1141 gagcttgact cgcagagcgg aggtgatagg tgggttacac actagatacg ggagctgctt
     1201 tgcttcttcg taggtgatct gctggtcgac tgagggaaag tgtccctgca gttcctgaaa
     1261 tagggttttg tatacagaca tgttgttgca gatttgatag agaccgaaga tcatcgagtt
     1321 cgaagtggtg tcgttacctg cggtgaggag tatcacggcc tcgtcgttta gctgttctag
     1381 gcttggtacg gtgtggcctt tgacggtgag gggatccatg agcatgtcta tcacagctga
     1441 tctgtccgca tgggctgcaa tggctgatgg cacgttgacg tcttcgcggg ctacgtagac
     1501 ggctgaatgt ggatcgaaaa cttccaggta gctcttggtg atggctcgac atttctgcac
     1561 atgttgttag cgatgtggtc tatgagtgag tagccgcacc cgcctcaccc gtttgaaatc
     1621 gataagagga ttaggaatga ccgagaagtc gctcatcgaa gccatccaga gtgcgagcgt
     1681 agctaacctg gggaaggcag ttgcgatcca tcccgtttcg aaagctgcgt tcaagttctc
     1741 gatgaaactg tttctgaagt cgggctcttc gatgcatcca atctcacgtc cgagaacaat
     1801 cttggagatg atatccatgg taagtgcttt acaagcgctg gtgatgcaga tggtctttgc
     1861 agattgtgca cagaggtcca cccttcttag tagccgttct accttgacga ggatcgcggg
     1921 ggcgagctct tggactcggg tgccagacag agcgggtgtt agcactttgc gacggattcg
     1981 actctgtgcg ggatcggtct ctccaatcga cgttcctgga aacgagatgc atcgatagaa
     2041 atgaggatct ttcgtgaagc ccgagctcac tttggtcatc gcctgataga cttcagggtc
     2101 gtctatgctg agatcgttca cgcctatccg taccaccggt cctgggctag tcgttagcaa
     2161 tgtgcggtct ccaagcaggc ttctagttta ccgtattgct tgtgtaacct ctgaatctca
     2221 aatatcattt gtccgttgag ataataattc caataccact cgtaccatga gttcgacact
     2281 gcggctaccc ttggtccccg atatcgtgat aacgggtgga agtgaaggcg gtagatggcc
     2341 agtagaaccc agtaggcaac aaaaaggccg caactcagca cgagccagcc tatattgcta
     2401 gggacaaaca taatctgaat ttagagcgaa agtgaaagct cgtaagtgcc aattctctga
     2461 tgtgcggtac ttctcttgat gagatccttt tgcgtatggg aacatatggg tttcggaatc
     2521 gtaagtgcca ttgagctttg acatggtaac ttcagagttt cgatgcatag tcctcgtcgt
     2581 acccaacctt cagagcacac caaggaacat ctaccggatg cccagtggta gaacgctaat
     2641 cttcgagccg aatctgaatc tgtaatctga gtcagccngt gcattcgtta aaacgtggcg
     2701 ccacgcctgt tgatggtaga gccgagaaaa atcggccgat cagttaaatc cgtaaggcgc
     2761 cctggggtga gattcttcag ctgcgtcacg tctcctgggt atcagatcct cccatagtac
     2821 ttggtgagca tcgtggaggg ttttacgcag acctggctgt ctccactgtg gttacgcccg
     2881 ctgatggacc cttaggcttg tttgctagta gtcgtggcgt tttagttcaa ggccgagcca
     2941 acatggaggc aaagaggact aatatatgtg ttgacatgct tggagttgga taaaagaaca
     3001 cacgagagct catcccaaac agtttgtcca acaactcatc tagttcgctt tcatttctca
     3061 gtattgactg acgtcacgcc aatctgacaa gatgcgtctc attatcttga atttgttgag
     3121 ccttgggatt accccatccg tcgtcggaca ttctggaccg catcgccaag aaactcaaaa
     3181 cttgaacaat ttcttggaat cgaatgcaat aaaccctgca gcaataaacg gagaaaccag
     3241 acacactgga ggagtacacc tcgcttgcgc aattctggaa gcatccaatc agactgcggt
     3301 cgtgtttcct agtgatgggg aactgtatac gcagatcgat aaggcacacg cgtgagtgaa
     3361 tgtccacatc cggcatccgt tctggactga catgaacttc cagttcagca acggcaccaa
     3421 agaacccagc gtgcatctat acaccgaatg atgtcaaagg tgtttctctg ggtgtcaagg
     3481 tcgccacttt cgtacaggcg aaatttgcca tccgcagtgg agggcattcg ccaatggagt
     3541 acttcgccaa cattgacggg ggcgtcctca tttcattggc tggcatcaag acgttagagt
     3601 ataatgcaga cactcaaacc cagcgctccg gatttggtaa cctctggcaa gatgtctatc
     3661 gacacgtgaa cgcacaggga cggaccgtcg ttggcggccg caccggcagc gttgggttgg
     3721 ctctcaccct tggaggtaag ctgttgtgca accttcggat acgacgaaca tactgaattg
     3781 ctgcaggtgg gctttcgcac ttctctaatg cttatggttg ggctgcacaa aatgtgctct
     3841 catatgaaat ggttctggct gatggctcca tcgtcatcgc cagtgaggag gagaattctg
     3901 atctgtactt tgccgtcaaa gctggcgcga acaatttcgg ttggtgtcct cgtccgcatc
     3961 tacagcatgt tgcttacgat cgacaggcat tgttacgcac atcgtacaga ggacgtaccc
     4021 actcggtaag atatggggag gttccatgat cttcccagga aatgcctcag cgcagttcat
     4081 ggctgccttg gcagactacc aagcgaaggg tcagctggac aagaagtctg ccatcttgcc
     4141 ttatgtcggg cttatcgcgg acgcagttgt cgcccagttt tcctatctgg aacctgtgga
     4201 gaggcccgaa gcgttcgaag ctttttacga tattccagtt atccaagact tgacgcaggt
     4261 ttgggacacg tttgcggcca tggtgacagc accgattccc tacaacatga ccaggttttc
     4321 ctatgccacc acagacttgt tgtacgacaa ggaggcctat ttggagatcg aacgaatatg
     4381 ccacaaatac atcccgcgaa tgcgaaagct ggaaggtgga gatatcatgc ttatgccaca
     4441 gccaatctcg gtatctatgg tgggggaggc ccgtgcacgc ggatcggatc cgatgggcgt
     4501 tgcggaccag ccgcagctgt gtacgtagga agcactcctc tcggtatcgc cgattaacaa
     4561 gagttcttat agggttcgtg gttagctcag gatggaactt ggcccaagac gacgctgaag
     4621 cggagagtat catgctggac gccctggctg aggttgaaga gtacaccaag tctcgggcct
     4681 tgcacctacc tttttacttc cttaacgatg ccttcagcac gcagatgccg ctgcaaagtt
     4741 atggggctgt gacttacggt aagctgcagg cggccagcag gaagtacgac ccgacccgcg
     4801 tgtttcagga attggttccc ggcggcttca aactagtcta gtctaggcta tcggattcag
     4861 gaaggtttag aacgttcatt ggatgagtat ctatggtagc ggcacatttg cgctttcttt
     4921 ttactttaca tgcacataga acgtacagtg tgcttgtttt caagcttgct gggggtcgtc
     4981 ccgttccgcg accgcttcca aagacgccaa aatctcactg cgttcacctt gtcaactaca
     5041 tgcacgagag tgtaaaggtc gctttttcgg gctcctggga ggcctactgt ggcgcgataa
     5101 tcattggttt tgagctttgg ggaacggtca actacatgca gtgcctagta atattttctc
     5161 ttttcggtac atgtccgtga gtctcacgtt gtatgagacc caattttttc ggtaccatct
     5221 cattcaggag cgtcgataaa gagtcttact tttggataat gctggataac aaatcgattg
     5281 aagagtaagc ggggcggatc aaagagggac atagatcagc agttcgttac tgcctaggta
     5341 gcttggactc tcatatccga catagtaaaa ttacacacat cgcccatttg ttactcgcgg
     5401 cgtagagtca gcgtcgctca gaagattcca ttcgccactg cttttcataa gtccgaccgg
     5461 acgatgtcag aaaaggcact acgaaaacgt gccgtactct cctgcatacc ttgctactcg
     5521 aagaaacaaa aggtacgcaa ggcgtcgcac gccccaaccc cgaaactgac aacaaaacct
     5581 tctgctagtg taaccgacaa tatccttgcg accattgcac acgaagacgt cgtcccgaac
     5641 tatgtaccta tgtatcgaaa cctcacccac gggtttctgg aaccacagac tgtcctacgc
     5701 acgaatcaga ttcatatcgc aataacatgt tgcaatttga cgatcctacc gcgggtatgg
     5761 cagaacgacg tacaagtcca ccctgggaag agatggagag tggggaagag agatccgaaa
     5821 gcggaaacaa ccaagccctg ccaacactgg tcaacgttta cgggtacttt gaagaaagtg
     5881 aatccaatac atgggccctc ttacgccaag tgagtaaacc cggggtgctg gtcttcgttt
     5941 ctcctgcctt ggaattctca cagctgtgcc accccccgtt gtgtgtccac ctgcctatgg
     6001 atccctgctg atgtatgtgt caagtgcgga ttgcacgaca gaagcaaccc acatgagtac
     6061 aacacgatga tgccttccac cctcatccac gacgttcaaa aagaactaaa ggatctgcca
     6121 gctcgaggca tcgtggactt cctgatacag tacttcttcg aagacatcaa ttggatcaac
     6181 cagatcgtcc atccgcctcg cttgcttgca caatacgaga actggtggaa aatggataca
     6241 ataacccggg tcgcagacct ggagttcgca gtcttgatgc tgcgaatctg cgcatacgct
     6301 tcccacttcc tcccgtcgaa aaagtatact gtagatacga tcaagggtag accactgtct
     6361 gatattcgga gtaactgtga ccggctcgct ggacgacttg aaggcatctg caacgccgca
     6421 gtgctacgtg gatcgctcgt gcgggttcag tacatggctt ttacggccat gtgttatgaa
     6481 tgcgacagcc gcatcaagtt gtcctgggat actctgtgtt gcgccatcag agaagctcag
     6541 gaggtaggac tccataggga gcctccgatg cggggcgacg atggcatgga cgatctagaa
     6601 agagaaatgc ggcgcaggat gttctgcaac ctgtacattt gggactagtt agtttacggg
     6661 aatccgaatt cttccttcat atgctaacga tgttgttagt cgccttgcaa aagcccttga
     6721 ccgtgttccg tttcttgtag atgcgtactg caccgtaagc ctgccgcaga tgcatctgca
     6781 ccccaccatc gccaacctcc aagcaccgga cctattcacc gagagagtac tccaagcaca
     6841 actggtacgg ttctggaaga agctcgaagc cgtcaatggc ccccctgggg ctcggccgta
     6901 cgatcccgtt attgctgaag aacgttatca gaggttttgt aatgagtttc ttccagaact
     6961 ccctgccccg tttgccttgg aaccgaacac cgattgggac cagcacatac ccgaacttcc
     7021 tcgccaaaga gaattgttcc atgttgctct cttcgagtca gtcatgcaca acttcaggca
     7081 actgctccgt ttagaccagc atcacctacg cagcctgcca aattccagga tggccctcgt
     7141 cacccagcac cggcacacac tggccaccgc tgcgatgggc ttattccaaa gcgtcacatc
     7201 actgcatgca atgatgagct tcaaccagac caagctatcg ttggttatct tctatcattt
     7261 tgagatggcg gtagtcttga gcctgtgcat aatacgggcc tgtgattcga atggcatgca
     7321 agatctggaa cacatcaact tcttcagccc gcatagcccg ctgtcttcaa acatgatcga
     7381 tatctcccaa agccagtgcc tgcgaactat caaggaggcc cggcgccaac tcgagatgat
     7441 gtctctaggt agcgtcatgg cggagacggg ggcgcgtcaa ttgggtatac tagtagatca
     7501 tgtccaggca acactggcta gatcaggtac acagacacga tccatgccat cgactgagac
     7561 tctaacctat aactcaagct cttcaacgtc ctatggggat ggccacgctc atggggtctc
     7621 atcggagctg ccgtttacct tccagcagca ggaagggccc acggcgaatg cgttccgaac
     7681 tgacagcaat gtgtttgaag gcttgatgct gtgggatctg tccactgatg cgttacctct
     7741 cgatccaagc tttttaggct tggaacagct tcatgagatc agcgaattac aaccgaatat
     7801 gggcttgtga tacttagttt aggcgacgga gtagaaagaa ttatgcatag aacggtgaac
     7861 tactaagcga ttatgaacgt gagcagactc ggccgtaacg tcgcgatgca gatgcacagg
     7921 aagaagcgtg acagggcgtg gcaagctcat gattgggtac cgagtagacg gtcctgtctt
     7981 cacccctgtg tccgttaagc ccgcaaagcc cggctggcag ccgacacggt tcggctggct
     8041 ttgttactcc ctttggaatt tcccagacct tgcgatgccc ctccacctcg cgacctgtca
     8101 acgtcagctg ggcgcgccaa gttatccttc acttatcttc tcgcagcttc ccgctcgtat
     8161 tgcttcccag atgctcggcc ctactgttgc ttgattgttc ctgtcctctc cccaaatcta
     8221 ccacaaacac ctaggtgaac cacatctgcc catctgctgc attataccac tcctattgcc
     8281 cctcatcgcc aacatgggtg gtatgcttgg tttcttcgtt cgccagctca ccttcatgcc
     8341 gaagccgctc ccccaaaatg ttcgccttga tggcaagact gccatcgtca ccggcgccaa
     8401 tgtcggcctc ggtctagaag cttccaagga aatggccagc catggtttgg ccagagtcat
     8461 tcttggagtg cgtacggtct cgaaaggcga ggctgcaaag caagagatcc tcaaacagtc
     8521 tccgaattgc gatgtgcaag tctggcctgt tgatcatgag tctttcgaga gcatggtggc
     8581 ctttggagag cgcgcccagt ccctcgatcg cctggacatt gtcatcttgt gcgctggtgt
     8641 caagaacctt gtcttctccc tctccaagac tggccacgag cagaacgttc aggttggtac
     8701 tctgtatacg tctgactacg gcatactgac tgatcctctg taggttaatc acctggggac
     8761 ctctcttctc tctctgttgc tgctcaagcc gctcaaagac acggctgcga agacgggctc
     8821 gccttcacgc ctcactattg tcgcgtcaga ggtccacttc tggaccccat tcgacgagcg
     8881 aaaggccccc tccattctcg ctcgtttgga tgagaaggac tcattcaggg gcatggaacg
     8941 ctacaacacg agcaagctat tgaacatcct ctggatgcgc gagcttagca gcagggttac
     9001 cggcaacgtt gtcatcaatg cggtcaaccc aggcctttgc gccagtgcct tacaccgtac
     9061 tgacccgact ccaggcttgg cctatctcaa caagatcttt gcttggacac ccgcccaggg
     9121 tgggcacaat ctgacgtacg cggcgactca gcatgtcgat gagcctggtg cgtacctgtc
     9181 cgagcagcat ttggagaagt aagcccccga cattgtagta gtggtgcgga gaagtcatac
     9241 taacacaatg caggccatct cctttcgtgc tttctaccga gggcaagacg tcgcaacaga
     9301 ggatttggga cgagactatc gccttgttca aggagaaggt tccgaacgtg gacattgaga
     9361 gcggcttgta gcttttagcc aacggatgtt atgcctgctc gttggtcgct tccgttttcc
     9421 ctgctcccgt gcttgagtat tgtgttagac tgataggtaa tcgagcaaaa caattccctt
     9481 ttttccaaac ggaattctgc tatctagaac aggttttcgt tgctgtgctg tcggatgtga
     9541 agggtgcaat gcagtacgga gcgatttcgc taatgtttat acaacagagc tgcatactaa
     9601 cgggttcttg gtttccttca attcaggcac acaattggag gccaggagtc ataattgttc
     9661 tattccatgt tcatcggaac tgtcaggttt gcagcccttt tcgccggtct gaacacgtca
     9721 caatgacgtc atcaaatatt cagatgaacc tcgactagac ccatgctgcc atcagcatga
     9781 acacgacgaa tctcatacct cgcatcggct tccttcaaca acgcctcgaa ctcctttgct
     9841 gttcgctgct tagcacccag aactacaaac atgagcatgt ccatctgcct gagagcgcgc
     9901 tcctcatgca agggcttcga ccccggcacc gggagcacag tgtcgttgat aagcagcggc
     9961 gtcccaggtg cagaattctc tagccccggc acgaaagact tgagaatctt gaccacgtcg
    10021 cggtcgcacc agttgtgcgt gcactggcgg atgaagaacg cgccggcgcc gccaataggc
    10081 tgtgggtgga agaagctgtg cttcatgaag gagatgcggc cctcgatgtc gctcaagttg
    10141 cgcgcccgac cctgtgcgag catcttttcg gagtcatctt ggacgatgaa atcaagttta
    10201 gggaaattct gggtgcgaaa atgagatgtc agtcaagaaa tgaagtgatt aaggatcata
    10261 gcagatgcga ggaaggaaaa gcttacgcga gccaaagcca tggagatgtg gccactgccg
    10321 cctccaacgt caactacggt gcctttgatg tcgccccaag gaaaacagtc tctcagttcg
    10381 gcgatttgac gatccactgt caaaagctta gggattggcc tactagtgtg ggttcacgga
    10441 ctctacatac ctcgagtaac accagccatt gcctttgcga aacgcgccgc aaattggggg
    10501 ttttgctcat agtacgagaa cattggcaca ccgaagtagg tgttgaaggg agagtgtgtg
    10561 ctatcggagt cgttgggcga tgctttgatg caatctgaac aagccgtggc agccttgaag
    10621 cattcatcga gcctagaatg tggttaggac atccagtatc aatccagcgt tgcatgcatg
    10681 tgacacaaac atacatgtag tgtccagcac atctcagctc ctcgtcatca tggaacactg
    10741 ccgaagccgc cgtatgggca aagaatccag gtttgggctc cacgaagata cgatgcgttg
    10801 ccaacatacg cagcacacgc gccgttcgat cggcgtcaat tcctacttta tgtgcaagtg
    10861 tttcgacatc catggaccct tcaggcggaa tcagctggaa aaagccaaaa tcgaaggcta
    10921 cttgcagcgc cgccaagtcg ttaccaatca tgatgaatgg gcgcaggctg cgccttgggc
    10981 catcaacgag gcgctgaaga tcctctagag aggaggtgag gcttgtgtga agagcgaggt
    11041 actcttcagt ctcaggagga tccgcgcacc ctgggaggaa gctgggctgt gcatggccct
    11101 gggactccag atatgtgctg agacttgccg ccttctcgga gatattggct gccaaagagg
    11161 ccaagctggc cgcagaggcg gtgggaccag catgtgtacc gtttgtggat tttagcgcca
    11221 tggtgggagg taggatgaat ctctggttgc ggcacgtttt gatcgcaaag ggagaaggtt
    11281 tatggtttcg aattcacgaa gaaaaggtgc ttatgtcttg aaacctctca acctccgtct
    11341 cagctagacg tcgatttgga ccaaagcatt atgcaaacca ggaaactaat gctgtaagac
    11401 atcttgtacc tccgatgcac gctctttcgt ccaaacgaag accgcaaaag cgacgagaag
    11461 gccgctgcat gataccacgt gtctcgggaa acggccgaca gctcgtgtaa ttcttcgacc
    11521 gagagcccac acctttttag gccgatgttt ctcggtcctc ggcggactgt cagcaattct
    11581 ccctgcataa gtgtggctac tttactacct tttgataggc ccaataccta tctcgacccg
    11641 aatcttcgat cttcaagcga accgtctgcc ttacccatat gtccgtcggg gcgtgggcgg
    11701 aacagtctaa tctgtggacg ttcacagaag gatctggcgg ggtggggggt ctgactgaca
    11761 ggcggtgaac tcctgaagcc tcgatgttca catcacaagc tgtcatttca ttggagcatc
    11821 tttcttttca atgcatcatg acttgacggc tcttaaacgt aagctcaaaa ggcttcgtat
    11881 ggcgcagtcc acctacgaac caggttagag aagggaccgt ggacgcctgc gacaagatat
    11941 cacgtgacat gctatatcac ttacaaggct actagacgaa cgtctatcaa gaataaagcg
    12001 aagacccaaa tgacccgaag ccttaaaccc gtacaggaaa agcctcattt aggacctaga
    12061 cgagctgacg ccgtagatcg gccctcagcc atcgatttga gtgtatcctc ttggtcgcct
    12121 atcctcaaag aacacatgcg ccatccaaaa catagccagt aacgtcgtgt tgctgcttat
    12181 cggtgtcaga atagtttatg ccagtgttcg attcttggta tacgggcatt cagttgtcgg
    12241 cccaagattc tgcactgcat ggttgagctt atctgcatga tgcgggatat ctcagcagta
    12301 tcaaaacgag attggatact gtggagcaaa tccataacct agggtgccgt ccgaggagag
    12361 ggtgtaattt gcctacaaga cacctaaaga gtgaaacatt aaagctcgtt acacgctctc
    12421 gtttcctcgt tagactttgc tattcacata gacgaggaag tcaagaactt atcaatactc
    12481 tcctgatctg acgcttcatc gccagataat actttgacga tgacttccca atacggaacc
    12541 aatggcgctt ctgcagaccc agagccaatc gccattgttg gcatgggtag gcccaactat
    12601 gctacacaac aacttcacat gctaaccgtt tttcgcaggc tgtagatggc ctgggggcgt
    12661 tcgagacgcg tccagtctat gggaacttct aaagaacaag cgttcgggat acagagaatt
    12721 cggtgaccac cggttctctc gcaagggatt ccaccatccc aattctgagc acccaggcac
    12781 tgttgccacc gaaggaggct tcttgcttgc cgaagatccc cgactcttcg accatgcctt
    12841 ctttggtatt ggttcgctcg aggtggagac gatggacccg tcgcagagaa agctgcttga
    12901 agtggtctac gaagcttttg aaaactcggg agagccatgg gattctttct cgggatcgac
    12961 tactggcgtt tttgttggca acttcagctc tgatcatctc ataattcaag gcagagatac
    13021 ggatcatccc aggccgtacg cgagtgttgg taccggcaca agcattctca gcaaccgcgt
    13081 caattacata ttcaatctgc gaggacccag gtgagtattc attactttca ctaagttcaa
    13141 ccacagctct gagcaactgc ttctcaacaa ggcgtttcag tgctgattaa acacagtgtc
    13201 accatcgaca cagcttgctc ttcctcaatg tacgcattac acttggccat tagtgcgatt
    13261 aggaatggcg attgcgactc cgcgattgtg gctgcctcca ataccatcat cgatcccagt
    13321 acanaactta tgatgacgaa actcggtgtc ctttcgccca cttcgacgag tcacactttt
    13381 gattcctcgg cggacggtta cgcgcgcggc gagggcttct ctgcgctgta cttgaagagg
    13441 atgtcaaccg ctgttgacgg cgactacccc atacgtgctc ttgtcagggg ttctgcgctc
    13501 aatgccaacg gtcgcaccgg tggcattacc catcccggca gggagggcca ggaagctgtc
    13561 atccgcaagg cttacgaaaa cgccggcaat cttccaatga aggataccac gttctttgag
    13621 tgccatggca caggcacgcc cgtcggtgac ccgatcgaaa tctcagccat cggcaatgtt
    13681 ttcggttcgg cgaccacgcc agagaagccg cttcttgtgg gctccatcaa gaccaacatc
    13741 gggcacacag agcctgctag cgcaattgca ggcatcatga aggtggtgct ggcgcttgag
    13801 aatgggttca ttccccccag tatcggcatc aagaagctta atccaaagct tgacttgaag
    13861 ggtggccgta tcaacatctt gaccgaaaac actccttggc ccgacggcag agttcgccga
    13921 gccagcgtca actctttcgg ttatggcggt gcgaacggac attgtatcat tgacgatgtc
    13981 aggactgtgt tacctgatta caagaaaaga acagcaaaca cgtccatcgg tcacatcaac
    14041 ggccacacca acggccacac caacggccac accaacggcc acaccaacgg ccacaccaac
    14101 ggccacacca atggccacac caatggcgcc catgcgtccg atggtcataa cggacatcat
    14161 caaaacggaa tgaacggaaa ttctgcatcg catatgagtg aaaaagcgga caaggtccac
    14221 tatcccttct catataaacc caccttggtc aaggacttca atgccaaacc tcgacgacgt
    14281 gtgcttatcc cgttctccgc acacaatgaa gcctccctcg acctcaacat taccgccata
    14341 tccgaagcta tcaagaggga gaatttggcg gatgttgcct acaccctggc ggcaaaacgc
    14401 tcgagattca tgcagagaac tttccgcatc gtcgacagtg aaagccccgc taatggcttt
    14461 gcagtcaagg agaaggtact cgccagcggc acgcaaactg caaggcttgg ttttgttttc
    14521 actggacagg gagcccagtg gcacgcgatg ggcgcagacc tgttcgaata cgccgtcttc
    14581 cgaacctcca tcgagtatct cgactctatt cttgccagcc tgccaacacc gtcagcttgg
    14641 aagatcgaag acattctggc agggaattgc gatcccaatg acattcacaa gccggaggtc
    14701 tcccagaccg tgtgtaccgc tgttcaaatc ggccttgtcg acctgctcta tacatggaac
    14761 gtcaggcctt ctgcagcagt tggacactcg tcaggagaga tagcggcaac gtatgcagct
    14821 ggccggatca cagctgcaca ggcgattgct gccgcctact ttcgaggcca agccgtatcc
    14881 aagaacaaga gcaaaggtct tatgttggcg gtcggactgg gcctagacaa agctgaggca
    14941 tacatctctg gcttggattc cagcgtcaga atcgctgcta tcaactcgcc cgacagcgta
    15001 acgctctctg gtgatgagtc taccatcaag gatgttgccg ctaagctcaa tgaagacaaa
    15061 gtgttcaacc gagagctcaa gactgggggt aacgcatatc attcccacca tatgcttgct
    15121 ctgggtgagt tctataacag caccctctcc gaaggccttg attacgtcaa gtctctgggc
    15181 caggctgaac cgtcacaatt gtatgccaca cggccatgga tgtcatctgt ctatccaagc
    15241 aaaagtaccg agaatcctcc cgtctctcca agttactggc gcgccaacct ggaatcccca
    15301 gtacgcttct cggaggcctt ggccaatatg ttgaatcttc cagatccgat tgacgtgctc
    15361 gtcgagatcg ggccacaccc tgctctcaaa ggtcccgttg gccagatctc gagaagcgtc
    15421 gacaagtcac tgccgtattt cccgaccttg aaccgcggta caaatggagg gatcagcttg
    15481 cttcaactcg ccggtagtct attcagtctg aatgccgaag tggacctcac tgccgtgaac
    15541 gccgttgatg tgattagcgc caaccagttg aagcttgtcc atggcactac tgcaaccaac
    15601 ctcccgcctt atcagtacgc atatggaccg gtcatatacc acgaaagccg cttcagcaag
    15661 gagttccgtg ggcgagatat tgttcggcac gacctgctgg gatcaaagct tccaggaaat
    15721 gccaagttgc ggccacagtg gcgaaatatc cttcgattaa aagatctccc ttggctcaac
    15781 gaccacaagc tcctcccata tcctgtgttt cctgctgcgg gttacatcgc gaccgtaatc
    15841 gaggcagcgt cgcgcatata caatgaacag agtgagccac ttgacattac tggatacaag
    15901 ctccgcaatg tcaccttctc ttcggccatg aggcttccgg atgatgactt tggtctcgag
    15961 attatcacga gcctagagct tgccgacgct gcaaatccca aagcacccac atgggccacg
    16021 ttctccatta gctccgtcgc acgtgaggcc ggcacatgga cagaacattg ttctggtcgg
    16081 gtcagggtga ttgccggaac atccgttgcc aatgagaaga tgtctacaga gatggacgct
    16141 cgaaccttgg acacgaaagc ctggtacaag aaatttgccg agattgggtt gggctacggc
    16201 ccgacctttc agcccttgtc caacattcga gctgatccat ccaagggctt ggctgttgct
    16261 cagttggcct tacacactac acgtgataca gtcgagggag gagagtcgaa ttacccgctt
    16321 caccctgcat ctctagatgc tgtgttccaa ctgtcacttg ttgccagtca tggtggccag
    16381 atcgaccgag tttgcaatgc ctttgtcccg gttcatatag accagctata tgtccgcaat
    16441 ggagtttcac aggactcggc cgtagcaatc gctcttggat cgatgaaggg cctgcgcagt
    16501 gctcatgcga aattgcaagt gctggacaaa tcggaacagg tagtgttaga cgtgggcaac
    16561 cttcgctgcg tcacctacac agaagtcttg ccctctacgg gcgctgacaa agaggcgttc
    16621 tccatcccct tcctacgttt gtcgtggaaa cccgatattc gtgccatgga caatgagcaa
    16681 gttcagcgac gatttccccc tcctacggag aatgtcgaga aagcgtacct gtttgacaaa
    16741 ctggaacggc ttgggacgct ctatgttgct gaaatacatg agcgttatgc gggccaaggc
    16801 caattttctt cagcnccagc gcatattgat aacttcctgt cctgggttcg aaggcgtatg
    16861 aaggacgaca acaaatgggt tgccgaggct aacagtctaa caagttctca acgcggcata
    16921 ctcatcaagg aactgttcgc ggaggtcggg cacatttcgg acgtcaagat cgccaacaaa
    16981 gtattcaaca acatggaaga catcttgaac gagcgcaaga cgggtctcga ggtcgtgatc
    17041 ccggacaacc ttcttcacgg catgtacgag gacggcctca tcatgacagg agcgtaccct
    17101 cagctcgtcc gcttcttcga cctgtttgga tacgcgaatc ccaatatgcg catcctcgaa
    17161 atcggtgccg gaaccggtgg tgctacacga aagatcctca aaacgttgat tgggccccac
    17221 ggcatcaaaa gataccagga ctacacgttc actgacatct cgagtggttt tctggcgcaa
    17281 gctcgcgagg cgtttgccga tttccaggac atgaagtatt ccgtgcttga tatccaagag
    17341 aacccgcttg agcacggtta cgaagcagtt tacgatgtgg tcgtggcttg cgagtgcttg
    17401 catgccaccc cgagtatcgt aaagactctg accaactgcc ggaagctggt caagccgggc
    17461 ggcagacttg tcgttgtgga aaacacacgg gcagtcatcg gccacggatt ggttcttgga
    17521 cacttgtcgg gctactggga tggaattccg gatggtcgtg tcgaaagtcc cttcctgcac
    17581 ctagagggct ggaatgcttc gcttaaccag actggcttcg ccggcgctga gctcgtcttg
    17641 gatgattacc ctgctccata caccactgct cgcacgattg tatctagcgc agtcgaagag
    17701 cctgcgaagg ttggccagtc tccgaacgga acagtacatc ttgttcatgg tgacaacaga
    17761 cccgaattac taagtcgaat cgaacatgag ctcaccgagc gtgggactga gtttaaggtt
    17821 atctccatag gggacgttga gactcatctg cccgacaact cacgcaccgt tgcctttgcc
    17881 gacagcaaaa gtctgctcgt caatgcaagc gagaatgatc tcaaatcttt caaagcgtta
    17941 atccgcaagt ccgcaaactt ggtttgggta acttttggtg gcatcgtcca cggccatgat
    18001 cccgacgctt cgatcactac gggtcttcta cgcacgcttg ggaccgaaaa ccccgcttcg
    18061 caattcctat cgattgacgt tagtcccgac agcgacttcc aagagatacg gctgacccgt
    18121 accattctcg accaggagct tgccctgtcc gatcgcatcg ccggcgagag tcgagattac
    18181 gagtttgtat ggcaagagga ctgtctctgg gtcagcagat tggttcccga tgtcgcacta
    18241 caagataaac tcgagctatc cgagagtcga cccagccgcg ctgagatgct gcctctggat
    18301 tcccaaggaa gcgtccaagc cgcctttgag acgcctggtc tcttgacgtc cttgtacttc
    18361 aagccgtacg aagaaacatg gaagtctttg cctgatgact ggatccaagt gaaggtggct
    18421 gcagtcggcc tcaactggaa agatcttctc acttccgccg gccgcttcga tatgaacacc
    18481 ttctcctcgg agtactctgg cgtcgtagcc caggttggtt taaatgtgac aaacgttgca
    18541 gtcggcgacc gtgtatacgg atacggtaga ggtcactttg gcaactacgt acgtgcgcca
    18601 gccaacttcg cttaccgtat gctgcctggg gaagattttg tcaagatggc cacgattccc
    18661 ctggttggga tgacagctat ctactcattc gaatgtgtta cccaactgaa ggaccaggag
    18721 aggctcctca ttcagtcagc cactggtggg cttggtcttt ctgccattca actggcaaag
    18781 gccaagggag cagagatttt tgccacagcg ggaacgcaag agaagcgtcg ttatctcatc
    18841 gacgttgtag gcatccccgc ctcgcacgtc ttttcgtctc gcgatcctgc cgactttgcc
    18901 aagctcatgg aagccactga cggcaaaggt ttcaatgtca tcctgagcac gtcgagtgga
    18961 gagttgctct atgactccat caaaatgctg gctcccatgg gtcgaataat cgacgtcggc
    19021 cgtattgacg tgcaaaactc cacatcgtta gcccttgagc tgttcaagcg caatgcgact
    19081 ttcacgtcct ttgacttggc tgtggcggat gacgcggacc gggctctcgg tcctgctctt
    19141 atgaaagctg tcaacaaacg tgtcagagct ggacaaatgg ggccgctgag ctccatcacg
    19201 acgtacgacg tgtcacagct agatcaagcc ctaatggcct tctctaaggg tacacacgtc
    19261 ggcaagctgg tcgtcacgtt ccagaatccg gacgctttgg tcaagatggt gcccgcagcg
    19321 ccgcatgctc agttcgccag gaatgccaat taccttatca caggtgggtt gggcggccta
    19381 ggcaggagca tcgtcaactt catggccgaa cgtggagcga gacacttcac cgtcctgtcg
    19441 cgcagtcgaa agatcaattc agagggtcaa atgctcatcg acaagctcgc cacttctggg
    19501 actgtagtgg agtgcgtcag ctgcgatgtt agtgacagta aagacgttgc ccgggctgtt
    19561 caagacgctg ctgttgtccg acccatcaaa ggtatcgtcc acgctgcagt ctcttaccag
    19621 gtaagatggt tacttccacc ttccgccgcg atatagatct aacaagcatc ctaggatcta
    19681 tcattcgaca aactcgcgat tgagcaatgg acatctgcgc tggcggccaa ggtccagggt
    19741 actaagaatc tgcacgaagc caccaagact catgcactag acttcttcct catgaccacg
    19801 acgatcgagt ctttcgtcgc actcgccacg cagtcggcct atactgctgc gaacaacttc
    19861 caggactact ttgcacgatg gcgacgccaa cagggtctac cagcctcgac ggtctcgttc
    19921 ggccttatcc gtgatgttgg ccatctcagt accaacagca ctacgctcgc tttgatggcc
    19981 cgtaacaagg tcatggacat ttccgagtac aacttcctcc ggcttcttga accagctttc
    20041 ttgaacaatg agtcggcgct tgatcctgcc gccagcaaag aaccatatac tggtgccgtg
    20101 gacgacccgc tctctgtgac gaacgtggtc acttgcttcg accctgccac tatggcgacc
    20161 cgcaagcgcg aagaagcggc ggaaaacaat ggcaacacgg gcaacagtcc acgttggtac
    20221 actgatgccc gtgtctcgct catcatgcga gcgtttgacg atgccgagcg ctaccaggcg
    20281 tcggctggcg gcggcggtga cggcggcaac gaaagaggca acaacgccgg cgttgcgagc
    20341 ttgcgtagtg aatttggaga ggccgtcaag gcgggcccag ccgagcgatc cagaaccgta
    20401 gcgttggtga cagacgcgat tgtgaagacg gtggcccaga tgctgtttgt tgatgcttcg
    20461 ggtgtcgatg cttcgcgcac agtggcggat tacggtgtcg acagtctgat tgcagcggag
    20521 ttgcgcaact ggttcaacgt cgcatttgga gcggatgtca gtatgctgga aatgttggac
    20581 actgctacga gtatgaagat tttggcgaac aagattgttg atggggctct tgcgtagtgg
    20641 tacagatgta gatgatgaag aatttcgaag tcgcgatcaa ggaacacttc atgtgtcaca
    20701 tgatgccaag catggcatct gccgggtgta taggcgccat cccatcttag ttagctcttc
    20761 agactcaata tacatcattc atgaccccac atatcacatt gggggacaca ctgtgcgaga
    20821 gcggtcgccg aggtacgtga ttagggtttt ttcatactgc tgcaattagg acacgatgcc
    20881 tccgcagggc aaaattccgt cgtcatttga ttttctagta aagtattcat cgggtggcac
    20941 aattcccgct agatgcaaca cgcccctgtg accctctttg aagtaaatgc cctggcgtgc
//
