BGC0000146 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000146 (Alternaria solani)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	21,000	High	solanapyrone D	PKS

BGC0000146 - Region 1 - T1PKS

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Location: 1 - 21,000 nt. (total: 21,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 21,001
Label		BGC0000146

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

sol3: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

sol5: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

sol6: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: methyltransferase

sol2: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

sol1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000146.3	1.00	PKS	solanapyrone D	Alternaria solani
BGC0002515.2	0.90	PKS	solanapyrone A	Ascochyta rabiei
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002155.3	0.52	PKS	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002240.3	0.50	PKS	BAB, BAA	Metarhizium anisopliae
BGC0002525.3	0.50	PKS	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002320.3	0.50	terpene	conidiogenone	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000146.3	1.00	PKS	solanapyrone D	Alternaria solani
BGC0002515.2	0.90	PKS	solanapyrone A	Ascochyta rabiei
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002155.3	0.52	PKS	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002240.3	0.50	PKS	BAB, BAA	Metarhizium anisopliae
BGC0002525.3	0.50	PKS	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002320.3	0.50	terpene	conidiogenone	Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 21000:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

sol1: pk

PKS_AT (619..934): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 62.5%; Propionyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 79.3
Methoxymalonyl-CoA: 75.5
Ethylmalonyl-CoA: 47.4
Malonyl-CoA: 47.3
Propionyl-CoA: 44.5
trans-1,2-CPDA: 20.2
CHC-CoA: 19.4
2-Methylbutyryl-CoA: 18.7
fatty_acid: 17.9
Isobutyryl-CoA: 17.5
Benzoyl-CoA: 10.3
3-Methylbutyryl-CoA: 8.9
inactive: 0.0
Acetyl-CoA: 0.0

Link to PARAS substrate predictor