BGC0000147: soraphen A biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 67,523 nt. (total: 67,523 nt).
This entry is originally from NCBI GenBank U24241.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000147
Short description soraphen A biosynthetic gene cluster from Sorangium cellulosum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolactone)
Loci NCBI GenBank: U24241.2
Compounds
  • soraphen A
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
soraphen A
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C29H44O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAK19886.1
 57 - 986 (+) unknown
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  • AAK19887.1
 1424 - 6127 (+) unknown
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  • AAK19892.1
  • sorE
 7505 - 8896 (-) acyl-CoA dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • AAK19885.1
  • sorD
 9199 - 10080 (-) dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • AAK19884.1
  • sorC
 10080 - 12671 (-) putative methoxymalonyl-CoA synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • AAK19893.1
  • sorR
 13697 - 14158 (+) reductase
  • Tailoring (Reduction)
Sequence-based prediction
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  • AAK19883.1
  • sorA
 14325 - 33272 (+) soraphen polyketide synthase A
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAA79984.2
  • sorB
 33269 - 59722 (+) soraphen polyketide synthase B
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAK19888.1
 59795 - 60226 (+) unknown
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  • AAK19894.1
  • sorM
 60255 - 61295 (+) O-methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AAK19889.1
 61362 - 63353 (-) unknown
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  • AAK19890.1
 63970 - 65478 (+) beta-mannanase
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  • AAK19891.1
 65934 - 66941 (+) xylanse-arabinofuranosidase bifunctional enzyme
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Polyketide-specific information
Subclass Macrolactone
Starter unit Benzoyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
sorB
+
sorA 		Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: sorA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Specificity: Malonyl-CoA
Genes: sorA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Specificity: Glycolate
Evidence for specificity: Structure-based inference
Genes: sorA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: sorB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: sorB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: sorB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Specificity: Glycolate
Evidence for specificity: Structure-based inference
Genes: sorB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 8
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: sorB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add PK subclass (issue #4)
  • Remove leading/trailing whitespace in gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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