BGC0000147 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000147 (Sorangium cellulosum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	67,523	soraphen A	PKS:Type I	100%

BGC0000147 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 67,523 nt. (total: 67,523 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 67,524
Label		BGC0000147

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000147	1.00	Polyketide	soraphen A	Sorangium cellulosum
BGC0000041	0.45	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164	0.30	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001163	0.29	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000706	0.28	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001647	0.27	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001283	0.26	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000067	0.25	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001504	0.25	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001162	0.23	Polyketide	1-heptadecene	Moorea producens JHB

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000147	1.00	Polyketide	soraphen A	Sorangium cellulosum
BGC0000041	0.76	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164	0.64	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001163	0.63	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000706	0.61	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001647	0.60	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001283	0.59	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000067	0.59	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001504	0.58	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001162	0.56	Polyketide	1-heptadecene	Moorea producens JHB

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 67523:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (redmal - pk) + (ohmal - Me-redmal - Me-ohmal - pk - Me-ccmal)
Non-colinear ordering:: sorC + sorA + sorB

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

sorC

PKS_AT (100..404): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 136.4
inactive: 82.9
Methoxymalonyl-CoA: 65.7
Methylmalonyl-CoA: 52.2
Propionyl-CoA: 46.5
2-Methylbutyryl-CoA: 28.4
Ethylmalonyl-CoA: 23.4
CHC-CoA: 21.4
Isobutyryl-CoA: 16.2
Acetyl-CoA: 14.5
Benzoyl-CoA: 14.0
3-Methylbutyryl-CoA: 13.9
trans-1,2-CPDA: 11.7
fatty_acid: 0.0

sorA

PKS_AT (633..930): pk

ATSignature: Benzoyl-CoA

Top 3 matches:: Benzoyl-CoA: 100.0%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 62.5%

minowa: Benzoyl-CoA

Prediction, score:

Benzoyl-CoA: 279.7
Isobutyryl-CoA: 131.3
Methylmalonyl-CoA: 121.7
Ethylmalonyl-CoA: 101.1
Methoxymalonyl-CoA: 100.1
Malonyl-CoA: 68.5
Acetyl-CoA: 55.6
trans-1,2-CPDA: 55.5
2-Methylbutyryl-CoA: 54.4
Propionyl-CoA: 52.6
3-Methylbutyryl-CoA: 49.5
CHC-CoA: 49.3
inactive: 33.4
fatty_acid: 23.4

PKS_AT (1065..1367): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 226.4
inactive: 133.5
Methoxymalonyl-CoA: 76.7
Methylmalonyl-CoA: 67.6
Isobutyryl-CoA: 45.3
Propionyl-CoA: 40.1
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 25.3
Benzoyl-CoA: 21.5
Acetyl-CoA: 16.7
trans-1,2-CPDA: 9.6
CHC-CoA: 6.2
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2627..2929): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.3
inactive: 129.3
Methoxymalonyl-CoA: 67.9
Methylmalonyl-CoA: 57.0
Isobutyryl-CoA: 41.5
Propionyl-CoA: 26.8
2-Methylbutyryl-CoA: 23.1
Acetyl-CoA: 16.3
Benzoyl-CoA: 12.1
Ethylmalonyl-CoA: 11.9
CHC-CoA: 3.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4708..4999): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.7
Ethylmalonyl-CoA: 204.0
Methoxymalonyl-CoA: 196.3
2-Methylbutyryl-CoA: 147.1
trans-1,2-CPDA: 138.5
Propionyl-CoA: 119.3
Malonyl-CoA: 117.3
CHC-CoA: 105.6
Isobutyryl-CoA: 102.4
Benzoyl-CoA: 76.6
Acetyl-CoA: 62.1
fatty_acid: 47.0
3-Methylbutyryl-CoA: 47.0
inactive: 38.6

sorB

PKS_AT (563..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.3
inactive: 129.3
Methoxymalonyl-CoA: 67.9
Methylmalonyl-CoA: 57.0
Isobutyryl-CoA: 41.5
Propionyl-CoA: 26.8
2-Methylbutyryl-CoA: 23.1
Acetyl-CoA: 16.3
Benzoyl-CoA: 12.1
Ethylmalonyl-CoA: 11.9
CHC-CoA: 3.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2126..2422): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.9
Ethylmalonyl-CoA: 204.2
Methoxymalonyl-CoA: 180.5
2-Methylbutyryl-CoA: 154.9
trans-1,2-CPDA: 121.8
Propionyl-CoA: 118.5
CHC-CoA: 116.2
Malonyl-CoA: 101.4
Isobutyryl-CoA: 100.7
Benzoyl-CoA: 79.5
Acetyl-CoA: 63.0
fatty_acid: 50.5
3-Methylbutyryl-CoA: 29.2
inactive: 26.6

PKS_AT (4202..4497): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.9
Ethylmalonyl-CoA: 195.6
Methoxymalonyl-CoA: 173.8
2-Methylbutyryl-CoA: 147.6
trans-1,2-CPDA: 120.1
Propionyl-CoA: 112.9
CHC-CoA: 109.5
Malonyl-CoA: 98.0
Isobutyryl-CoA: 96.7
Benzoyl-CoA: 71.5
Acetyl-CoA: 64.9
fatty_acid: 41.1
inactive: 25.8
3-Methylbutyryl-CoA: 20.4

PKS_AT (5758..6052): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Methylmalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 215.1
Methylmalonyl-CoA: 213.5
Methoxymalonyl-CoA: 202.1
2-Methylbutyryl-CoA: 149.1
trans-1,2-CPDA: 142.7
Propionyl-CoA: 117.0
CHC-CoA: 111.6
Malonyl-CoA: 106.1
Isobutyryl-CoA: 97.1
Benzoyl-CoA: 74.7
Acetyl-CoA: 54.4
fatty_acid: 45.4
inactive: 45.2
3-Methylbutyryl-CoA: 44.7

PKS_AT (7312..7608): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.1
Ethylmalonyl-CoA: 201.6
Methoxymalonyl-CoA: 179.2
2-Methylbutyryl-CoA: 156.9
trans-1,2-CPDA: 122.3
Propionyl-CoA: 116.1
CHC-CoA: 111.7
Isobutyryl-CoA: 105.7
Malonyl-CoA: 103.8
Benzoyl-CoA: 73.6
Acetyl-CoA: 71.4
fatty_acid: 45.7
3-Methylbutyryl-CoA: 40.6
inactive: 28.4