Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000147.1:
Cluster 1Polyketide167523

BGC0000147, soraphen biosynthetic gene cluster from Sorangium cellulosum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Soraphen
SMILES string: Copy to clipboard
Molecular formula: C29H44O8
Exact molecular mass: 521.3109 Da ([M+H]+)
Molecular activity: Antifungal
Molecular target: fungal acetyl-CoA carboxylase inhibitor

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Modular type I
Starter unit:
Benzoyl-CoA
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
sorA (AAK19883.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Other
KR stereochemistry: B-group
Module 3
AT specificity: Glycolate
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

sorB (AAA79984.2)
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 6
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 7
AT specificity: Glycolate
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 8
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

Gene cluster description

soraphen (BGC0000147). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank U24241, positions 1-67523. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Ligon J et al. (2002) Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26. Gene 285(1-2):257-67.