BGC0000147: soraphen A biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 67,523 nt. (total: 67,523 nt).
This entry is originally from NCBI GenBank U24241.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000147
Short description soraphen A biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
U24241.2
via Heterologous expression
Compounds
  • soraphen A
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
soraphen A Evidence:
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C29H44O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAK19886.1
 57 - 986 (+) unknown
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    • AAK19887.1
    		 1424 - 6127 (+) unknown
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      • AAK19892.1
      • sorE
      		 7505 - 8896 (-) acyl-CoA dehydrogenase
      • Precursor biosynthesis
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      • AAK19885.1
      • sorD
      		 9199 - 10080 (-) dehydrogenase
      • Precursor biosynthesis
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      • AAK19884.1
      • sorC
      		 10080 - 12671 (-) putative methoxymalonyl-CoA synthase
      • Precursor biosynthesis
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      • AAK19893.1
      • sorR
      		 13697 - 14158 (+) reductase
      • Tailoring
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      • AAK19883.1
      • sorA
      		 14325 - 33272 (+) soraphen polyketide synthase A
      • Scaffold biosynthesis
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      • AAA79984.2
      • sorB
      		 33269 - 59722 (+) soraphen polyketide synthase B
      • Scaffold biosynthesis
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      • AAK19888.1
      		 59795 - 60226 (+) unknown
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        • AAK19894.1
        • sorM
        		 60255 - 61295 (+) O-methyltransferase
        • Tailoring
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        • AAK19889.1
        		 61362 - 63353 (-) unknown
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          • AAK19890.1
          		 63970 - 65478 (+) beta-mannanase
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            • AAK19891.1
            		 65934 - 66941 (+) xylanse-arabinofuranosidase bifunctional enzyme
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              Biosynthesis information

              Biosynthetic modules

              Name
              1
              Type
              pks-modular
              Genes
              sorA
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
              Name
              2
              Type
              pks-modular
              Genes
              sorA
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
              Name
              3
              Type
              pks-modular
              Genes
              sorA
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
              Name
              4
              Type
              pks-modular
              Genes
              sorB
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
              Name
              5
              Type
              pks-modular
              Genes
              sorB
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
              Name
              6
              Type
              pks-modular
              Genes
              sorB
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
              Name
              7
              Type
              pks-modular
              Genes
              sorB
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
              Name
              8
              Type
              pks-modular
              Genes
              sorB
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Add PK subclass (issue #4)
              • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Remove leading/trailing whitespace in gene identifiers
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated bioactivity data
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2019-10-16
              Updated compound(s) information (NPAtlas curation)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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