BGC0000150: sporolide A biosynthetic gene cluster from Salinispora tropica CNB-440
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Location: 3,027,087 - 3,086,780 nt. (total: 59,694 nt).
This entry is originally from NCBI GenBank CP000667.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000150
Short description sporolide A biosynthetic gene cluster from Salinispora tropica CNB-440
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Enediyine)
Loci NCBI GenBank: CP000667.1
Compounds
  • sporolide A
  • sporolide B
Species Salinispora tropica CNB-440 [taxonomy]
References
Chemical products information
sporolide A
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C24H23Cl1O12
sporolide B
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C24H23Cl1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Strop_2691
  • ABP55135.1
 3027087 - 3027416 (-) hypothetical protein
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  • Strop_2692
  • ABP55136.1
 3027520 - 3028152 (-) transcriptional regulator
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  • Strop_2693
  • ABP55137.1
 3028644 - 3029429 (+) transcriptional regulator, AraC family
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  • Strop_2694
  • ABP55138.1
 3029601 - 3030959 (-) cytochrome P450
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  • Strop_2695
  • ABP55139.1
 3030956 - 3031492 (-) flavin reductase domain protein, FMN-binding
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  • Strop_2696
  • ABP55140.1
 3031492 - 3031956 (-) hypothetical protein
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  • Strop_2697
  • ABP55141.1
 3031962 - 3037733 (-) beta-ketoacyl synthase
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  • Strop_2698
  • ABP55142.1
 3037730 - 3038716 (-) hypothetical protein
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  • Strop_2699
  • ABP55143.1
 3038722 - 3040689 (-) ASPIC/UnbV domain protein
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  • Strop_2700
  • ABP55144.1
 3040693 - 3041691 (-) protein of unknown function DUF1702
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  • Strop_2701
  • ABP55145.1
 3041874 - 3042851 (-) protein of unknown function DUF1702
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  • Strop_2702
  • ABP55146.1
 3043140 - 3044204 (+) NAD-dependent epimerase/dehydratase
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  • Strop_2703
  • ABP55147.1
 3044128 - 3045210 (-) alkylhydroperoxidase like protein, AhpD family
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  • Strop_2704
  • ABP55148.1
 3045293 - 3046945 (-) glucose-methanol-choline oxidoreductase
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  • Strop_2705
  • ABP55149.1
 3046942 - 3047505 (-) hypothetical protein
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  • Strop_2706
  • ABP55150.1
 3047931 - 3048851 (+) Wyosine base formation
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  • Strop_2707
  • ABP55151.1
 3049000 - 3049611 (+) hypothetical protein
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  • Strop_2708
  • ABP55152.1
 3049948 - 3051120 (+) Acyl-CoA dehydrogenase, type 2, C-terminal domain
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  • Strop_2709
  • ABP55153.1
 3051279 - 3051698 (+) hypothetical protein
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  • Strop_2710
  • ABP55154.1
 3051728 - 3053107 (+) monooxygenase, FAD-binding
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  • Strop_2711
  • ABP55155.1
 3053122 - 3054279 (+) Epoxide hydrolase domain protein
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  • Strop_2712
  • ABP55156.1
 3054480 - 3055646 (+) luciferase family protein
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  • Strop_2713
  • ABP55157.1
 3055726 - 3057276 (+) 4-hydroxyphenylacetate 3-hydroxylase
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  • Strop_2714
  • ABP55158.1
 3057393 - 3058703 (-) Sigma-70, region 4 type 2
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  • Strop_2715
  • ABP55159.1
 3058700 - 3059080 (-) DGPFAETKE family protein
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  • Strop_2716
  • ABP55160.1
 3059835 - 3060125 (+) hypothetical protein
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  • Strop_2717
  • ABP55161.1
 3060126 - 3061049 (+) hypothetical protein
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  • Strop_2718
  • ABP55162.1
 3061524 - 3063110 (-) major facilitator superfamily MFS_1
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  • Strop_2719
  • ABP55163.1
 3063558 - 3063917 (+) DGPFAETKE family protein
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  • Strop_2720
  • ABP55164.1
 3064097 - 3065341 (-) Acyl-CoA dehydrogenase, type 2, C-terminal domain
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  • Strop_2721
  • ABP55165.1
 3065529 - 3066860 (+) condensation domain protein
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  • Strop_2722
  • ABP55166.1
 3066965 - 3068305 (-) hypothetical protein
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  • Strop_2723
  • ABP55167.1
 3068318 - 3069334 (-) Alcohol dehydrogenase GroES domain protein
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  • Strop_2724
  • ABP55168.1
 3069331 - 3070560 (-) cytochrome P450
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  • Strop_2725
  • ABP55169.1
 3070970 - 3072736 (+) amino acid adenylation domain
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  • Strop_2726
  • ABP55170.1
 3072733 - 3072942 (+) MbtH domain protein
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  • Strop_2727
  • ABP55171.1
 3072970 - 3074046 (+) 4-hydroxyphenylpyruvate dioxygenase
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  • Strop_2728
  • ABP55172.1
 3074043 - 3074945 (+) hypothetical protein
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  • Strop_2729
  • ABP55173.1
 3075278 - 3075574 (+) hypothetical protein
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  • Strop_2730
  • ABP55174.1
 3075612 - 3076169 (+) hypothetical protein
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  • Strop_2731
  • ABP55175.1
 3076625 - 3078043 (-) FAD linked oxidase domain protein
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  • Strop_2732
  • ABP55176.1
 3078123 - 3079193 (+) hypothetical protein
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  • Strop_2733
  • ABP55177.1
 3079206 - 3080726 (+) Methyltransferase type 11
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  • Strop_2734
  • ABP55178.1
 3080799 - 3081056 (+) hypothetical protein
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  • Strop_2735
  • ABP55179.1
 3081183 - 3082628 (-) major facilitator superfamily MFS_1
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  • Strop_2736
  • ABP55180.1
 3082666 - 3083334 (-) protein of unknown function DUF899, thioredoxin family protein
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  • Strop_2737
  • ABP55181.1
 3083472 - 3086780 (+) transcriptional activator domain
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Polyketide-specific information
Subclass Enediyine
Starter unit Malonyl-CoA
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
Strop_2696
+
Strop_2697 		Synthase subclass: Enediyne type I
Thioesterases:
  • Strop_2696 (Type II)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: Strop_2697
Core domains: Ketosynthase, Acyltransferase, Ketoreductase
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
Strop_2721
Module 2 [inactive]
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FGOE6VD55GZRETNYSNOKUJZO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
Detailed domain annotation
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