Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000150.1:
Cluster 1NRP / Polyketide159694

BGC0000150, sporolide biosynthetic gene cluster from Salinispora tropica. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: sporolide
SMILES string: Copy to clipboard
Molecular formula: C24H23ClO12
Exact molecular mass: 538.087803907 Da (None)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Nonribosomal peptide synthetases:
No gene ID (ABP55165.1)
Module 2
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
Module is non-elongating
Evidence for non-elongation: Unknown
Polyketide subclass:
Enediyine (cyclic)
Polyketide synthase subclass:
Enediyne type I
Starter unit:
Malonyl-CoA
STRO2697
Thioesterase type:
Type II
Release / cyclization type:
Unknown

Modular polyketide synthases:
No gene ID (ABP55141.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

sporolide (BGC0000150). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP000667. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Nadine Ziemert (University Tuebingen)

Literature references

1. McGlinchey RP et al. (2008) Unraveling the biosynthesis of the sporolide cyclohexenone building block. J Am Chem Soc 130(8):2406-7. doi: 10.1021/ja710488m. Epub 2008 Jan