BGC0000153: stigmatellin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
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Location: 1 - 66,808 nt. (total: 66,808 nt).
This entry is originally from NCBI GenBank AJ421825.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0000153
Short description | stigmatellin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)
- PKS (Type I)

Loci
AJ421825.1
via Knock-out studies
Compounds

- stigmatellin

Species Stigmatella aurantiaca Sg a15 [taxonomy]
References

- [1] Metabolic diversity in myxobacteria: identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilone producing strain Sorangium cellulosum So ce90. Beyer S et al., Biochim Biophys Acta (1999) PMID:10320771

Chemical products information
stigmatellin Evidence:
Copy SMILES
C30H42O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
CAD19077.1 | 4978 - 6231 (-) | cytochrome P450 monooxygenase |  |  | copy AA seq copy Nt seq
CAD19078.1 | 6369 - 7730 (+) | protein kinase |  |  | copy AA seq copy Nt seq
CAD19079.1 | 7849 - 8577 (-) | methyl transferase |  |  | copy AA seq copy Nt seq
CAD19080.1 | 8622 - 8879 (-) | acyl-CoA binding protein |  |  | copy AA seq copy Nt seq
CAD19081.1 | 8961 - 10070 (+) | potassium channel beta chain |  |  | copy AA seq copy Nt seq
CAD19082.1 | 10428 - 10862 (+) | ribosome binding factor |  |  | copy AA seq copy Nt seq
CAD19083.1 | 10859 - 12016 (+) |  |  |  | copy AA seq copy Nt seq
CAD19084.1 | 12082 - 13974 (-) | cellulase |  |  | copy AA seq copy Nt seq
CAD19085.1 stiA | 14345 - 21466 (+) | StiA protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19086.1 stiB | 21463 - 26220 (+) | StiB protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19087.1 stiC | 26284 - 31941 (+) | StiC protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19088.1 stiD | 31943 - 37738 (+) | StiD protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19089.1 stiE | 37740 - 43553 (+) | StiE protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19090.1 stiF | 43546 - 50202 (+) | StiF protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19091.1 stiG | 50205 - 54401 (+) | StiG protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19092.1 stiH | 54398 - 59212 (+) | StiH protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19093.1 stiJ | 59223 - 63002 (+) | StiJ protein | Scaffold biosynthesis |  | copy AA seq copy Nt seq
CAD19094.1 stiK | 63070 - 63840 (+) | methyl transferase | Tailoring |  | copy AA seq copy Nt seq
CAD19095.1 stiL | 63899 - 65470 (+) | cytochrome P450 dependent monooxygenase | Tailoring | Knock-out | copy AA seq copy Nt seq
CAD19096.1 | 65537 - 66808 (+) | polynucleotide adenyltransferase |  |  | copy AA seq copy Nt seq

Biosynthesis information

#### Biosynthetic modules

Name
1
Type
pks-modular
Genes
stiA
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
Name
2
Type
pks-modular
Genes
stiB
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
3
Type
pks-modular
Genes
stiC
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
Name
4
Type
pks-modular
Genes
stiD
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
Name
5
Type
pks-modular
Genes
stiD
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
Name
6
Type
pks-modular
Genes
stiE
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
Name
7
Type
pks-modular
Genes
stiF
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
Name
8
Type
pks-modular
Genes
stiG
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
9
Type
pks-modular
Genes
stiH
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
Annotation changelog

#### Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Fixed incorrect gene identifiers

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2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases

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2022-09-15
Updated bioactivity data

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#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

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2019-10-16
Updated compound(s) information (NPAtlas curation)

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#### Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted

- (ID: 7SR74ARK6JXRBGJRGO2LUHE7)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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