BGC0000154 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000154 (Talaromyces stipitatus ATCC 10500)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	32,135	stipitatic acid	PKS:Iterative type I	100%

BGC0000154 - Region 1 - T1PKS

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Location: 1 - 32,135 nt. (total: 32,135 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,136
Label		BGC0000154

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000154	1.00	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0000099	0.39	Polyketide	monascorubrin	Talaromyces marneffei
BGC0001893	0.31	Other	abscisic acid	Botrytis cinerea B05.10
BGC0001286	0.31	Other	itaconic acid	Ustilago maydis
BGC0002429	0.29	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0000670	0.27	Terpene	thalianol, thaliandiol	Arabidopsis thaliana
BGC0002483	0.27	Polyketide	usnic acid	Cladonia uncialis subsp. uncialis
BGC0000669	0.27	Terpene	marneral	Arabidopsis thaliana
BGC0002603	0.26	Polyketide	chevalone E	Aspergillus versicolor
BGC0002427	0.25	Terpene, Polyketide	subglutinol A, subglutinol B	Metarhizium robertsii ARSEF 23

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000154	1.00	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0000099	0.71	Polyketide	monascorubrin	Talaromyces marneffei
BGC0001893	0.65	Other	abscisic acid	Botrytis cinerea B05.10
BGC0001286	0.64	Other	itaconic acid	Ustilago maydis
BGC0002429	0.63	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0000670	0.61	Terpene	thalianol, thaliandiol	Arabidopsis thaliana
BGC0002483	0.60	Polyketide	usnic acid	Cladonia uncialis subsp. uncialis
BGC0000669	0.60	Terpene	marneral	Arabidopsis thaliana
BGC0002603	0.60	Polyketide	chevalone E	Aspergillus versicolor
BGC0002427	0.59	Terpene, Polyketide	subglutinol A, subglutinol B	Metarhizium robertsii ARSEF 23

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 32135:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

TSTA_117750

PKS_AT (901..1198): mal

ATSignature: Ethylmalonyl-CoA, Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 58.3%; Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 58.2
Methoxymalonyl-CoA: 57.6
Methylmalonyl-CoA: 52.2
inactive: 43.4
Ethylmalonyl-CoA: 29.2
Propionyl-CoA: 28.4
fatty_acid: 25.8
CHC-CoA: 24.3
Benzoyl-CoA: 22.5
trans-1,2-CPDA: 21.8
2-Methylbutyryl-CoA: 20.6
3-Methylbutyryl-CoA: 13.4
Isobutyryl-CoA: 12.8
Acetyl-CoA: 12.7