BGC0000154 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000154 (Talaromyces stipitatus ATCC 10500)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	48,060	High	stipitatic acid	PKS:Iterative type I

BGC0000154 - Region 1 - T1PKS

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Location: 1 - 48,060 nt. (total: 48,060 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 48,061
Label		BGC0000154

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

TSTA_117730: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

TSTA_117730_rename1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

TSTA_117790: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

TSTA_117820: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthase

TSTA_117750: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000154.4	1.00	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.62	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001219.3	0.58	PKS	shanorellin	Chaetomium globosum CBS 148.51

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000154.4	1.00	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.62	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001219.3	0.58	PKS	shanorellin	Chaetomium globosum CBS 148.51

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 48060:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

TSTA_117750: mal

PKS_AT (901..1198): mal

ATSignature: Ethylmalonyl-CoA, Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 58.3%; Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 58.2
Methoxymalonyl-CoA: 57.6
Methylmalonyl-CoA: 52.2
inactive: 43.4
Ethylmalonyl-CoA: 29.2
Propionyl-CoA: 28.4
fatty_acid: 25.8
CHC-CoA: 24.3
Benzoyl-CoA: 22.5
trans-1,2-CPDA: 21.8
2-Methylbutyryl-CoA: 20.6
3-Methylbutyryl-CoA: 13.4
Isobutyryl-CoA: 12.8
Acetyl-CoA: 12.7

Link to PARAS substrate predictor