BGC0000156: TAN-1612 biosynthetic gene cluster from Aspergillus niger
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Location: 1 - 13,275 nt. (total: 13,275 nt).
This entry is originally from NCBI GenBank JN257714.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000156
Short description TAN-1612 biosynthetic gene cluster from Aspergillus niger
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Tetracycline)
Loci NCBI GenBank: JN257714.1
Compounds
  • TAN-1612
  • 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione
  • desmethyl TAN-1612
Species Aspergillus niger [taxonomy]
References
Chemical products information
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TAN-1612
Molecular Formula C33O9
Chemical database entries PubCHEM   ChemSpider  
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1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione
Molecular Formula C26O8
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desmethyl TAN-1612
Molecular Formula C32O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Extra
  • AEN83885.1
  • adaR
501 3004 + AdaR
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  • AEN83886.1
  • adaD
3412 4161 - O-methyltransferase
  • Tailoring (Methylation) (evidence: KH)
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  • AEN83887.1
  • adaC
4637 5881 + AdaC
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  • AEN83888.1
  • adaB
6256 7260 - metallo-beta-lactamase-like thioesterase/Claisen cyclase
  • Scaffold biosynthesis (evidence: KHA)
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  • AEN83889.1
  • adaA
7894 13275 + AdaA
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Polyketide-specific information
Subclass Tetracycline
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
aen83889
+
aen83888
Synthase subclass: Iterative type I
Thioesterases:
  • aen83888 (Unknown)
Iterative PKS type: Non-reducing, C6-C11 first
Iteration counts: 9
Annotation changelog
MIBiG version Notes
2.0
  • Migrated from v1.4
Detailed domain annotation
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