Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000156.1:
Cluster 1Polyketide113275

BGC0000156, TAN-1612 biosynthetic gene cluster from Aspergillus niger. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: TAN-1612
PubChem ID: 9887988
ChemSpider ID: 8063660
SMILES string: Copy to clipboard
Molecular formula: C21H18O9
Average molecular mass: 414.366 Da
Molecular activity: Inhibitor
Molecular target: neuropeptide Y, neurokinin-1 receptor

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Tetracycline (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AEN83889
Iterative PKS subtype:
Non-reducing
Number of iterations:
9
C6-C11 first
Thioesterase type:
Other
Release / cyclization type:
Claisen condensation

Gene cluster description

TAN-1612 (BGC0000156). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank JN257714. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Yit-Heng Chooi (The Australian National University)

Literature references

1. Li Y et al. (2011) Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an alpha-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc 133(39):15773-85. doi: 10.1021/ja206906d. Epub 2011 Sep
2. Kodukula K et al. (1995) BMS-192548, a tetracyclic binding inhibitor of neuropeptide Y receptors, from Aspergillus niger WB2346. I. Taxonomy, fermentation, isolation and biological activity. J Antibiot (Tokyo) 48(10):1055-9.
3. Shu YZ et al. (1995) BMS-192548, a tetracyclic binding inhibitor of neuropeptide Y receptors, from Aspergillus niger WB2346. II. Physico-chemical properties and structural characterization. J Antibiot (Tokyo) 48(10):1060-5.