BGC0000158 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000158 (Streptomyces griseochromogenes)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	78,527	High	tautomycetin	PKS:Type I

BGC0000158 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 78,527 nt. (total: 78,527 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 78,528
Label		BGC0000158

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

ttnE: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

ttnI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Hydrolases: esterase

ttnH: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

ttnF: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

ttnP: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

Ligases: synthase

ttnA: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ttnB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000158.5	1.00	PKS	tautomycetin	Streptomyces griseochromogenes
BGC0000157.5	1.00	PKS	tautomycetin	Streptomyces sp. CK4412
BGC0000067.5	0.57	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000016.4	0.56	other (other)	amphotericin B	Streptomyces nodosus
BGC0001012.3	0.52	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0001298.4	0.52	PKS	4-Z-annimycin, 4-E-annimycin	Streptomyces calvus
BGC0000147.5	0.51	PKS	soraphen A	Sorangium cellulosum
BGC0000889.5	0.51	other (other)	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001051.5	0.50	NRPS, PKS	thuggacin A	Sorangium cellulosum
BGC0001495.3	0.50	PKS	actinoallolide A	Actinoallomurus fulvus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000158.5	1.00	PKS	tautomycetin	Streptomyces griseochromogenes
BGC0000157.5	1.00	PKS	tautomycetin	Streptomyces sp. CK4412
BGC0000067.5	0.57	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000016.4	0.56	other (other)	amphotericin B	Streptomyces nodosus
BGC0001012.3	0.52	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0001298.4	0.52	PKS	4-Z-annimycin, 4-E-annimycin	Streptomyces calvus
BGC0000147.5	0.51	PKS	soraphen A	Sorangium cellulosum
BGC0000889.5	0.51	other (other)	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001051.5	0.50	NRPS, PKS	thuggacin A	Sorangium cellulosum
BGC0001495.3	0.50	PKS	actinoallolide A	Actinoallomurus fulvus

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 78527:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ohmal - Me-ccmal - ccmal - Me-redmal) + (Me-redmal - redmal - pk - ohmal)
Non-colinear ordering:: ttnA + ttnB

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ttnB: mmal - mal - pk - mal

PKS_AT (584..865): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 198.4
Ethylmalonyl-CoA: 192.8
Methoxymalonyl-CoA: 165.6
2-Methylbutyryl-CoA: 135.3
trans-1,2-CPDA: 121.5
Propionyl-CoA: 111.8
Malonyl-CoA: 102.5
CHC-CoA: 97.5
Isobutyryl-CoA: 77.1
Benzoyl-CoA: 71.9
Acetyl-CoA: 53.3
inactive: 37.3
fatty_acid: 27.1
3-Methylbutyryl-CoA: 20.7

PKS_AT (2588..2864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.8
inactive: 96.2
Methoxymalonyl-CoA: 70.1
Methylmalonyl-CoA: 53.5
Propionyl-CoA: 38.4
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 30.7
Acetyl-CoA: 24.9
fatty_acid: 20.9
2-Methylbutyryl-CoA: 16.1
trans-1,2-CPDA: 16.0
Ethylmalonyl-CoA: 12.6
CHC-CoA: 9.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (4601..4894): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 168.3
Ethylmalonyl-CoA: 165.7
Methoxymalonyl-CoA: 141.1
2-Methylbutyryl-CoA: 127.9
Propionyl-CoA: 105.3
trans-1,2-CPDA: 102.2
CHC-CoA: 89.4
Malonyl-CoA: 74.7
Isobutyryl-CoA: 60.7
Benzoyl-CoA: 42.7
fatty_acid: 35.1
3-Methylbutyryl-CoA: 24.6
Acetyl-CoA: 24.4
inactive: 23.0

PKS_AT (6313..6589): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.8
inactive: 96.2
Methoxymalonyl-CoA: 70.1
Methylmalonyl-CoA: 53.5
Propionyl-CoA: 38.4
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 30.7
Acetyl-CoA: 24.9
fatty_acid: 20.9
2-Methylbutyryl-CoA: 16.1
trans-1,2-CPDA: 16.0
Ethylmalonyl-CoA: 12.6
CHC-CoA: 9.7
3-Methylbutyryl-CoA: 0.0

ttnA: mal - mmal - mal - mmal - mal - mmal

PKS_AT (529..805): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.8
inactive: 96.2
Methoxymalonyl-CoA: 70.1
Methylmalonyl-CoA: 53.5
Propionyl-CoA: 38.4
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 30.7
Acetyl-CoA: 24.9
fatty_acid: 20.9
2-Methylbutyryl-CoA: 16.1
trans-1,2-CPDA: 16.0
Ethylmalonyl-CoA: 12.6
CHC-CoA: 9.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (1506..1788): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.5
Ethylmalonyl-CoA: 182.9
Methoxymalonyl-CoA: 159.0
2-Methylbutyryl-CoA: 127.5
Propionyl-CoA: 105.1
Malonyl-CoA: 101.1
trans-1,2-CPDA: 99.8
CHC-CoA: 98.0
Isobutyryl-CoA: 78.1
Benzoyl-CoA: 75.9
Acetyl-CoA: 52.4
inactive: 34.8
3-Methylbutyryl-CoA: 29.2
fatty_acid: 25.8

PKS_AT (3179..3456): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.8
inactive: 96.2
Methoxymalonyl-CoA: 70.1
Methylmalonyl-CoA: 53.5
Propionyl-CoA: 38.4
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 30.7
Acetyl-CoA: 24.9
fatty_acid: 20.9
2-Methylbutyryl-CoA: 16.1
trans-1,2-CPDA: 16.0
Ethylmalonyl-CoA: 12.6
CHC-CoA: 9.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (4672..4950): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.7
Ethylmalonyl-CoA: 184.6
Methoxymalonyl-CoA: 161.6
2-Methylbutyryl-CoA: 127.9
trans-1,2-CPDA: 115.0
Propionyl-CoA: 108.2
Malonyl-CoA: 107.2
CHC-CoA: 99.1
Benzoyl-CoA: 82.1
Isobutyryl-CoA: 77.6
Acetyl-CoA: 56.7
inactive: 40.8
3-Methylbutyryl-CoA: 29.9
fatty_acid: 28.0

PKS_AT (6294..6570): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.8
inactive: 96.2
Methoxymalonyl-CoA: 70.1
Methylmalonyl-CoA: 53.5
Propionyl-CoA: 38.4
Isobutyryl-CoA: 31.6
Benzoyl-CoA: 30.7
Acetyl-CoA: 24.9
fatty_acid: 20.9
2-Methylbutyryl-CoA: 16.1
trans-1,2-CPDA: 16.0
Ethylmalonyl-CoA: 12.6
CHC-CoA: 9.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (7992..8274): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.0
Ethylmalonyl-CoA: 180.9
Methoxymalonyl-CoA: 158.7
2-Methylbutyryl-CoA: 127.1
Propionyl-CoA: 105.0
Malonyl-CoA: 102.4
trans-1,2-CPDA: 99.8
CHC-CoA: 98.1
Isobutyryl-CoA: 78.0
Benzoyl-CoA: 75.1
Acetyl-CoA: 51.8
inactive: 34.4
3-Methylbutyryl-CoA: 28.7
fatty_acid: 25.9

Link to PARAS substrate predictor