BGC0000158: tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 78,527 nt. (total: 78,527 nt).
This entry is originally from NCBI GenBank EU035755.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000158
Short description tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
EU035755.1
via Knock-out studies
Compounds
  • tautomycetin
Species Streptomyces griseochromogenes [taxonomy]
References
Chemical products information
tautomycetin Evidence:
Copy SMILES
C33H50O10
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABV91285.1
 449 - 1237 (+) probable transposase
    copy AA seq
    copy Nt seq
    • ABV91302.1
    • ttnQ
    		 1777 - 3195 (-) regulator
    • Regulation
    • Knock-out
    copy AA seq
    copy Nt seq
    • ABV91295.1
    • ttnJ
    		 3490 - 5172 (-) putative multidrug transporter
      copy AA seq
      copy Nt seq
      • ABV91294.1
      • ttnI
      		 5176 - 6525 (-) cytochrome P450
      • Tailoring
      • Knock-out
      copy AA seq
      copy Nt seq
      • ABV91303.1
      • ttnR
      		 6522 - 7934 (-) MmgE/PrpD family protein
      • Tailoring
      • Knock-out
      copy AA seq
      copy Nt seq
      • ABV91304.1
      • ttnS
      		 7931 - 8743 (-) putative cyclase
        copy AA seq
        copy Nt seq
        • ABV91293.1
        • ttnH
        		 8774 - 9553 (-) probable thioesterase
          copy AA seq
          copy Nt seq
          • ABV91292.1
          • ttnG
          		 9973 - 12753 (+) putative transcriptional regulator
            copy AA seq
            copy Nt seq
            • ABV91291.1
            • ttnF
            		 12770 - 14287 (+) dehydratase
            • Tailoring
            • Knock-out
            copy AA seq
            copy Nt seq
            • ABV91290.1
            • ttnE
            		 15238 - 16572 (-) predicted crotonyl-CoA reductase
              copy AA seq
              copy Nt seq
              • ABV91289.1
              • ttnD
              		 16600 - 18057 (-) decarboxylase
              • Tailoring
              • Knock-out
              copy AA seq
              copy Nt seq
              • ABV91288.1
              • ttnC
              		 18054 - 18683 (-) decarboxylase
              • Tailoring
              • Knock-out
              copy AA seq
              copy Nt seq
              • ABV91287.1
              • ttnB
              		 18689 - 41419 (-) type I modular polyketide synthase
                copy AA seq
                copy Nt seq
                • ABV91286.1
                • ttnA
                		 41439 - 70025 (-) type I modular polyketide synthase
                • Scaffold biosynthesis
                • Knock-out
                copy AA seq
                copy Nt seq
                • ABV91296.1
                • ttnK
                		 70295 - 71692 (+) putative type B carboxylesterase
                  copy AA seq
                  copy Nt seq
                  • ABV91301.1
                  • ttnP
                  		 71711 - 72862 (+) acyl-CoA transferases
                  • Precursor biosynthesis
                  • Knock-out
                  copy AA seq
                  copy Nt seq
                  • ABV91300.1
                  • ttnO
                  		 72859 - 73788 (+) probable citrate lyase beta subunit
                    copy AA seq
                    copy Nt seq
                    • ABV91299.1
                    • ttnN
                    		 73785 - 74876 (+) conserved hypothetical protein
                      copy AA seq
                      copy Nt seq
                      • ABV91298.1
                      • ttnM
                      		 74920 - 75939 (+) predicted hydroxylase
                      • Tailoring
                      • Knock-out
                      copy AA seq
                      copy Nt seq
                      • ABV91297.1
                      • ttnL
                      		 76039 - 76596 (+) conserved hypothetical protein
                        copy AA seq
                        copy Nt seq
                        • ABV91284.1
                        		 76744 - 78267 (+) putative glycosyl transferase
                          copy AA seq
                          copy Nt seq
                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          0
                          Type
                          pks-modular
                          Genes
                          ttnA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                          Name
                          1
                          Type
                          pks-modular
                          Genes
                          ttnA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                          Name
                          2
                          Type
                          pks-modular
                          Genes
                          ttnA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                          Name
                          3
                          Type
                          pks-modular
                          Genes
                          ttnA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                          Name
                          4
                          Type
                          pks-modular
                          Genes
                          ttnA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                          Name
                          5
                          Type
                          pks-modular
                          Genes
                          ttnA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                          Name
                          6
                          Type
                          pks-modular
                          Genes
                          ttnB
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                          Name
                          7
                          Type
                          pks-modular
                          Genes
                          ttnB
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                          Name
                          8
                          Type
                          pks-modular
                          Genes
                          ttnB
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                          Name
                          9
                          Type
                          pks-modular
                          Genes
                          ttnB
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, thioesterase, carrier (ACP)
                          Annotation changelog

                          Entry version: 4

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Corrected gene identifiers
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Updated bioactivity data
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2015-06-12
                          Submitted
                          • (ID: E2T2HCM4X7QXVS4LL4JVBPPK)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                          A domain glossary is available here, and an explanation of the visualisation is available here.
                          Selected features only
                          Show module domains
                          Similar known gene clusters from MIBiG 4.0
                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                          Click on reference genes to show details of similarities to genes within the current region.
                          Click on an accession to open that entry in the MiBIG database.