BGC0000159: tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus
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Location: 1 - 94,050 nt. (total: 94,050 nt).
This entry is originally from NCBI GenBank EF990140.1.

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core biosynthetic genes
additional biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000159
Short description tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: EF990140.1
Compounds
  • tautomycin
Species Streptomyces spiroverticillatus [taxonomy]
References
Chemical products information
tautomycin
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C41H66O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABW96537.1
 347 - 1027 (-) conserved hypothetical protein
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  • ABW96536.1
 1065 - 1427 (-) hypothetical protein
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  • ABW96535.1
 1316 - 1942 (-) hypothetical protein
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  • ABW96534.1
 2500 - 3213 (-) putative dehydrogenase
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  • ABW96533.1
 3409 - 5178 (+) putative MOSC ferredoxin--oxidoreductase
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  • ABW96532.1
 5384 - 6079 (+) hypothetical protein
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  • ABW96538.1
  • ttmF
 7322 - 8611 (+) putative regulatory protein
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  • ABW96539.1
  • ttmG
 8676 - 9206 (-) putative decarboxylase
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  • ABW96540.1
  • ttmH
 9369 - 26681 (-) type I modular polyketide synthase
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  • ABW96541.1
  • ttmI
 26694 - 43826 (-) type I modular polyketide synthase
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  • ABW96542.1
  • ttmJ
 43846 - 76329 (-) type I modular polyketide synthase
  • Scaffold biosynthesis
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  • ABW96543.1
  • ttmK
 76705 - 78075 (+) type B carboxylesterase
  • Scaffold biosynthesis
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  • ABW96544.1
  • ttmL
 78092 - 78664 (-) conserved hypothetical protein
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  • ABW96557.1
  • ttmE
 79404 - 80489 (-) phosphatase, methoxymalonyl-ACP biosynthesis protein
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  • ABW96553.1
  • ttmA
 80486 - 81607 (-) acyl-CoA dehydrogenase
  • Precursor biosynthesis
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  • ABW96556.1
  • ttmD
 81604 - 81858 (-) acyl-carrier protein
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  • ABW96554.1
  • ttmB
 81855 - 82724 (-) 3-hydroxyacyl-CoA dehydrogenase
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  • ABW96555.1
  • ttmC
 82892 - 83548 (-) O-methyl transferase
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  • ABW96545.1
  • ttmM
 83662 - 84723 (-) hydroxylase
  • Tailoring (Hydroxylation)
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  • ABW96546.1
  • ttmN
 84758 - 85864 (-) conserved hypothetical protein
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  • ABW96547.1
  • ttmO
 85861 - 86805 (-) probable citrate lyase beta subunit
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  • ABW96548.1
  • ttmP
 86802 - 88025 (-) acyl-CoA transferases/carnitine
  • Scaffold biosynthesis
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  • ABW96549.1
  • ttmQ
 88381 - 89436 (+) predicted transcriptional regulator protein
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  • ABW96550.1
  • ttmR
 89450 - 90853 (-) MmgE/PrpD family protein
  • Scaffold biosynthesis
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  • ABW96551.1
  • ttmS
 90850 - 91674 (-) cyclase
  • Unknown
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  • ABW96552.1
  • ttmT
 91736 - 92509 (-) probable thioesterase
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  • ABW96529.1
 92506 - 92778 (-) hypothetical protein
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  • ABW96530.1
 92966 - 93553 (+) hypothetical protein
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  • ABW96531.1
 93572 - 93961 (+) hypothetical protein
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Polyketide-specific information
Subclass Other
Starter unit Isobutyryl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
ttmJ
+
ttmI
+
ttmH 		Synthase subclass: Modular type I
Module 0
Specificity: Isobutyryl-CoA
Genes: ttmJ
Core domains: Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methoxymalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmJ
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmJ
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmJ
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmJ
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmJ
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmJ
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmI
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmH
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 11
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmH
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 12
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttmH
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP), Thioesterase
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: E2T2HCM4X7QXVS4LL4JVBPPK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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