BGC0000161 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000161 (Aspergillus terreus NIH2624)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	52,759	High	isoterrein	PKS:Iterative type I

BGC0000161 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 52,759 nt. (total: 52,759 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 52,760
Label		BGC0000161

Tailoring functions

Oxidoreductases: oxygenase

ATEG_00142: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ATEG_00143: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Lyases: dehydratase

ATEG_00137: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

ATEG_00145: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000161.4	0.96	PKS	isoterrein	Aspergillus terreus NIH2624
BGC0002154.2	0.68	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.68	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.68	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000161.4	1.00	PKS	isoterrein	Aspergillus terreus NIH2624
BGC0002154.2	0.68	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.68	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.68	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 6234 - 52759:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ATEG_00145: mal

PKS_AT (848..1145): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 102.3
inactive: 52.4
Methylmalonyl-CoA: 49.7
Methoxymalonyl-CoA: 49.1
Propionyl-CoA: 27.5
fatty_acid: 21.1
2-Methylbutyryl-CoA: 19.6
Benzoyl-CoA: 18.2
3-Methylbutyryl-CoA: 16.6
Acetyl-CoA: 15.7
Ethylmalonyl-CoA: 14.5
CHC-CoA: 14.0
Isobutyryl-CoA: 13.3
trans-1,2-CPDA: 8.6

Link to PARAS substrate predictor