Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000161.1:
Cluster 1Polyketide132759

BGC0000161, terrein biosynthetic gene cluster from Aspergillus terreus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: terrein
PubChem ID: 12443340
SMILES string: Copy to clipboard
Molecular formula: C8H10O3
Average molecular mass: 154.165 Da
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
ATEG_00145
Iterative PKS subtype:
Non-reducing
Number of iterations:
4
C2-C7 first
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Gene cluster description

terrein (BGC0000161). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank CH476594, positions 399827-432585. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Yuta Tsunematsu (University of Shizuoka)

Literature references

1. Zaehle C et al. (2014) Terrein biosynthesis in Aspergillus terreus and its impact on phytotoxicity. Chem Biol 21(6):719-31. doi: 10.1016/j.chembiol.2014.03.010. Epub