BGC0000162: tetrocarcin A biosynthetic gene cluster from Micromonospora chalcea
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Location: 1 - 108,236 nt. (total: 108,236 nt).
This entry is originally from NCBI GenBank EU443633.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General information about the BGC

MIBiG accession | BGC0000162
Short description | tetrocarcin A biosynthetic gene cluster from Micromonospora chalcea
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Unknown)

Loci
EU443633.1
via
Compounds

- tetrocarcin A

Species
Micromonospora chalcea [taxonomy]
References

- [1] Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics. Fang J et al., J Bacteriol (2008) PMID:18586939

Chemical products information
tetrocarcin A Evidence:
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C41H54N2O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
ACB37719.1 | 288 - 692 (+) | unknown |  |  | copy AA seq copy Nt seq
ACB37720.1 | 1965 - 2855 (+) | ATPase-like protein |  |  | copy AA seq copy Nt seq
ACB37721.1 | 2720 - 3280 (+) | putative two-component response regulator |  |  | copy AA seq copy Nt seq
ACB37722.1 | 3309 - 6404 (-) | DNA polymerase III alpha subunit |  |  | copy AA seq copy Nt seq
ACB37723.1 | 8022 - 9134 (+) | glycosyltransferase |  |  | copy AA seq copy Nt seq
ACB37724.1 | 9250 - 9810 (+) | possible flavoprotein oxidoreductase |  |  | copy AA seq copy Nt seq
ACB37725.1 | 9842 - 10171 (-) | unknown |  |  | copy AA seq copy Nt seq
ACB37726.1 | 10440 - 10880 (+) | biotin-requiring enzyme |  |  | copy AA seq copy Nt seq
ACB37727.1 | 11988 - 12791 (+) | putative pathway specific activator |  |  | copy AA seq copy Nt seq
ACB37728.1 | 12840 - 13442 (+) | bifunctional NDP-hexose 3,5- (or 5-) epimerase/putative dTDP-4-keto-6-deoxyglucose-2,3-dehydratase |  |  | copy AA seq copy Nt seq
ACB37729.1 | 13499 - 14497 (+) | 3-ketoreductase |  |  | copy AA seq copy Nt seq
ACB37730.1 | 14553 - 15731 (-) | glycosyltransferase |  |  | copy AA seq copy Nt seq
ACB37731.1 | 15890 - 16681 (-) | methyltransferase |  |  | copy AA seq copy Nt seq
ACB37732.1 | 16895 - 18037 (+) | aminotransferase |  |  | copy AA seq copy Nt seq
ACB37733.1 | 18170 - 19294 (+) | O-acyltransferase |  |  | copy AA seq copy Nt seq
ACB37734.1 | 19343 - 20230 (+) | glucose-1-phosphate thymidyltransferase |  |  | copy AA seq copy Nt seq
ACB37735.1 | 20227 - 21225 (+) | dTDP-glucose 4,6-dehydratase |  |  | copy AA seq copy Nt seq
ACB37736.1 | 21290 - 22594 (+) | putative flavoprotein |  |  | copy AA seq copy Nt seq
ACB37737.1 | 22600 - 23721 (+) | NDP-deoxyhexose 3-aminotransferase |  |  | copy AA seq copy Nt seq
ACB37738.1 | 23743 - 24987 (+) | methyltransferase |  |  | copy AA seq copy Nt seq
ACB37739.1 | 25068 - 25562 (+) | unknown |  |  | copy AA seq copy Nt seq
ACB37740.1 | 25663 - 44580 (+) | putative type I polyketide synthase |  |  | copy AA seq copy Nt seq
ACB37741.1 | 44582 - 65605 (+) | putative type I polyketide synthase |  |  | copy AA seq copy Nt seq
ACB37742.1 | 65631 - 71087 (+) | putative type I polyketide synthase |  |  | copy AA seq copy Nt seq
ACB37743.1 | 71162 - 75775 (+) | putative type I polyketide synthase |  |  | copy AA seq copy Nt seq
ACB37744.1 | 75796 - 77271 (+) | FAD-dependent oxygenase |  |  | copy AA seq copy Nt seq
ACB37745.1 | 77303 - 78355 (+) | 3-oxoacyl-ACP synthase III |  |  | copy AA seq copy Nt seq
ACB37746.1 | 78352 - 80253 (+) | FKbH-like protein |  |  | copy AA seq copy Nt seq
ACB37747.1 | 80250 - 80477 (+) | acyl carrier protein |  |  | copy AA seq copy Nt seq
ACB37748.1 | 80573 - 82324 (+) | 2-oxoacid dehydrogenase/acyltransferase |  |  | copy AA seq copy Nt seq
ACB37749.1 | 82467 - 83072 (-) | TetR-family transcriptional regulator |  |  | copy AA seq copy Nt seq
ACB37750.1 | 83214 - 84410 (+) | glycosyltransferase |  |  | copy AA seq copy Nt seq
ACB37751.1 | 84455 - 85594 (+) | glycosyltransferase |  |  | copy AA seq copy Nt seq
ACB37752.1 | 85725 - 87242 (-) | dehydrogenase |  |  | copy AA seq copy Nt seq
ACB37753.1 | 87262 - 88026 (-) | putative thioesterase |  |  | copy AA seq copy Nt seq
ACB37754.1 | 88070 - 89533 (-) | 2,3-hexose dehydratase |  |  | copy AA seq copy Nt seq
ACB37755.1 | 89839 - 101700 (+) | putative type I polyketide synthase |  |  | copy AA seq copy Nt seq
ACB37756.1 | 101715 - 102524 (-) | putative oxidoreductase |  |  | copy AA seq copy Nt seq
ACB37757.1 | 102653 - 104125 (-) | putative multidrug export protein |  |  | copy AA seq copy Nt seq
ACB37758.1 | 104374 - 105201 (+) | putative M23 peptidase domain protein |  |  | copy AA seq copy Nt seq
ACB37759.1 | 105310 - 105978 (+) | unknown |  |  | copy AA seq copy Nt seq
ACB37760.1 | 106120 - 106518 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
ACB37761.1 | 106599 - 106919 (+) | regulatory protein |  |  | copy AA seq copy Nt seq
ACB37762.1 | 106919 - 107650 (+) | putative Co/Zn/Cd cation transporter-like protein |  |  | copy AA seq copy Nt seq
ACB37763.1 | 107713 - 108159 (-) | putative alpha/beta hydrolase fold protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11

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#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Updated bioactivity data

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

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#### Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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