BGC0000164 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000164 (Streptomyces sp. NRRL 11266)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	113,234	tetronasin	Polyketide	36%

BGC0000164 - Region 1 - T1PKS

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Location: 1 - 113,234 nt. (total: 113,234 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 113,235
Label		BGC0000164

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000164.1	0.80	Polyketide	tetronomycin	Streptomyces sp. NRRL 11266
BGC0001164.1	0.35	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000041.1	0.32	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000122.1	0.31	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001273.1	0.31	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.31	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001304.1	0.30	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0001275.1	0.30	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001266.1	0.30	Polyketide	grayanic acid	Cladonia grayi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000164.1	0.93	Polyketide	tetronomycin	Streptomyces sp. NRRL 11266
BGC0001164.1	0.68	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000041.1	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000122.1	0.64	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001304.1	0.64	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001266.1	0.63	Polyketide	grayanic acid	Cladonia grayi

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 113234:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - mal - ohmal) + (ohmal) + (mal - ccmal - redmal) + (Me-ohmal) + (ccmal - ohmal) + (Me-redmal - Me-ccmal - ccmal) + (redmal - Me-redmal - Me-ccmal)
Non-colinear ordering:: tmnDI + tmnVI + tmnA1 + tmnAII + tmnAIII + tmnAIV + tmnAV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

tmnA1

PKS_AT (567..858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.5
inactive: 107.8
Methoxymalonyl-CoA: 64.5
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 32.2
Isobutyryl-CoA: 31.2
Ethylmalonyl-CoA: 28.3
Benzoyl-CoA: 17.5
Acetyl-CoA: 16.2
2-Methylbutyryl-CoA: 16.0
fatty_acid: 14.8
CHC-CoA: 13.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1576..1861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.7
inactive: 111.7
Methoxymalonyl-CoA: 78.8
Methylmalonyl-CoA: 70.7
Propionyl-CoA: 45.3
Isobutyryl-CoA: 36.5
fatty_acid: 31.8
CHC-CoA: 27.9
trans-1,2-CPDA: 22.1
Ethylmalonyl-CoA: 20.4
2-Methylbutyryl-CoA: 20.2
Acetyl-CoA: 20.1
Benzoyl-CoA: 18.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3334..3618): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.9
inactive: 116.1
Methoxymalonyl-CoA: 84.6
Methylmalonyl-CoA: 80.1
Propionyl-CoA: 57.3
Isobutyryl-CoA: 39.0
fatty_acid: 35.6
Ethylmalonyl-CoA: 33.8
CHC-CoA: 30.0
2-Methylbutyryl-CoA: 27.5
trans-1,2-CPDA: 21.3
Acetyl-CoA: 20.1
Benzoyl-CoA: 18.8
3-Methylbutyryl-CoA: 0.0

tmnVI

PKS_AT (568..855): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 147.0
inactive: 60.5
Methoxymalonyl-CoA: 57.1
Methylmalonyl-CoA: 51.6
Propionyl-CoA: 25.7
fatty_acid: 21.6
Ethylmalonyl-CoA: 20.2
CHC-CoA: 12.5
Isobutyryl-CoA: 12.1
trans-1,2-CPDA: 11.3
Acetyl-CoA: 10.5
2-Methylbutyryl-CoA: 10.1
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

tmnAII

PKS_AT (571..868): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 180.0
Ethylmalonyl-CoA: 151.3
Methoxymalonyl-CoA: 146.1
2-Methylbutyryl-CoA: 97.5
Malonyl-CoA: 87.7
trans-1,2-CPDA: 86.7
CHC-CoA: 85.9
Propionyl-CoA: 77.2
Isobutyryl-CoA: 58.8
Acetyl-CoA: 48.4
Benzoyl-CoA: 46.9
inactive: 30.5
3-Methylbutyryl-CoA: 26.2
fatty_acid: 24.7

tmnAIII

PKS_AT (566..875): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 167.3
inactive: 75.2
Methoxymalonyl-CoA: 55.3
Methylmalonyl-CoA: 42.7
Propionyl-CoA: 27.3
fatty_acid: 19.1
Ethylmalonyl-CoA: 18.7
trans-1,2-CPDA: 10.5
Isobutyryl-CoA: 10.4
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2336..2634): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 169.8
inactive: 90.5
Methoxymalonyl-CoA: 48.1
Methylmalonyl-CoA: 30.9
Propionyl-CoA: 25.9
fatty_acid: 25.6
Benzoyl-CoA: 16.9
Ethylmalonyl-CoA: 16.8
Acetyl-CoA: 16.5
2-Methylbutyryl-CoA: 14.3
Isobutyryl-CoA: 12.4
trans-1,2-CPDA: 10.6
CHC-CoA: 8.3
3-Methylbutyryl-CoA: 0.0

tmnAIV

PKS_AT (577..868): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 176.5
Ethylmalonyl-CoA: 156.4
Methoxymalonyl-CoA: 145.4
trans-1,2-CPDA: 110.7
2-Methylbutyryl-CoA: 103.8
CHC-CoA: 100.9
Propionyl-CoA: 91.1
Malonyl-CoA: 84.8
Isobutyryl-CoA: 62.7
Benzoyl-CoA: 42.4
fatty_acid: 28.2
3-Methylbutyryl-CoA: 27.0
Acetyl-CoA: 20.9
inactive: 11.9

PKS_AT (2650..2941): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 178.9
Ethylmalonyl-CoA: 161.3
Methoxymalonyl-CoA: 146.3
2-Methylbutyryl-CoA: 106.2
trans-1,2-CPDA: 105.2
CHC-CoA: 101.2
Propionyl-CoA: 93.4
Malonyl-CoA: 87.3
Isobutyryl-CoA: 60.3
fatty_acid: 42.4
Benzoyl-CoA: 37.5
3-Methylbutyryl-CoA: 25.7
Acetyl-CoA: 24.7
inactive: 12.0

PKS_AT (4396..4681): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 149.4
Methoxymalonyl-CoA: 63.9
inactive: 62.1
Methylmalonyl-CoA: 50.4
Propionyl-CoA: 25.8
Ethylmalonyl-CoA: 23.2
fatty_acid: 20.0
Acetyl-CoA: 16.0
Isobutyryl-CoA: 15.8
trans-1,2-CPDA: 14.9
CHC-CoA: 12.0
2-Methylbutyryl-CoA: 7.5
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

tmnAV

PKS_AT (567..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 150.7
inactive: 66.4
Methoxymalonyl-CoA: 64.6
Methylmalonyl-CoA: 52.9
Ethylmalonyl-CoA: 25.6
Propionyl-CoA: 23.8
fatty_acid: 17.5
trans-1,2-CPDA: 13.5
CHC-CoA: 11.9
Acetyl-CoA: 11.3
Isobutyryl-CoA: 11.2
2-Methylbutyryl-CoA: 4.2
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2641..2935): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 177.5
Ethylmalonyl-CoA: 157.7
Methoxymalonyl-CoA: 145.0
2-Methylbutyryl-CoA: 107.5
trans-1,2-CPDA: 105.5
CHC-CoA: 101.3
Propionyl-CoA: 93.8
Malonyl-CoA: 87.0
Isobutyryl-CoA: 60.5
fatty_acid: 42.8
Benzoyl-CoA: 29.5
3-Methylbutyryl-CoA: 27.1
Acetyl-CoA: 26.1
inactive: 11.9

PKS_AT (4702..4992): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 177.5
Ethylmalonyl-CoA: 152.3
Methoxymalonyl-CoA: 147.5
trans-1,2-CPDA: 114.6
2-Methylbutyryl-CoA: 108.6
Propionyl-CoA: 95.6
CHC-CoA: 95.5
Malonyl-CoA: 87.7
Isobutyryl-CoA: 60.4
Benzoyl-CoA: 43.2
fatty_acid: 39.3
3-Methylbutyryl-CoA: 26.3
Acetyl-CoA: 17.5
inactive: 11.6

tmnDI

PKS_AT (5..284): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 106.9
inactive: 38.5
Methoxymalonyl-CoA: 35.5
Methylmalonyl-CoA: 32.4
Propionyl-CoA: 28.9
fatty_acid: 22.2
2-Methylbutyryl-CoA: 17.2
Acetyl-CoA: 9.9
Isobutyryl-CoA: 5.5
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

tmn20

CAL_domain (180..494): pk

minowa: NH2

Prediction, score:

NH2: 46.0
fatty_acid: 25.6
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0