BGC0000165: tiacumicin B biosynthetic gene cluster from Dactylosporangium aurantiacum subsp. hamdenensis
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Location: 6,044 - 88,527 nt. (total: 82,484 nt).
This entry is originally from NCBI GenBank HQ011923.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000165
Short description tiacumicin B biosynthetic gene cluster from Dactylosporangium aurantiacum subsp. hamdenensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: HQ011923.1
Compounds
  • tiacumicin B
Species Dactylosporangium aurantiacum subsp. hamdenensis [taxonomy]
References
Chemical products information
tiacumicin B [synonyms: dificid, fidaxomicin, lipiarmicin, difimicin]
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C52H74Cl2O18
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADU86026.1
  • tiaG1
 6044 - 7441 (-) putative glycosyltransferase
  • Tailoring (Glycosylation)
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  • ADU85982.1
  • tiaS1
 7492 - 8508 (-) putative GDP-D-mannose dehydratase
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  • ADU85983.1
  • tiaS2
 8534 - 9742 (-) putative C-methyltransferase
  • Tailoring (Methylation)
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  • ADV15440.1
  • tiaS3
 9787 - 10785 (-) GDP-mannose 4,6-dehydratase
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  • ADU85984.1
  • tiaC
 11219 - 12280 (+) putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit
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  • ADU85985.1
  • tiaD
 12277 - 13254 (+) putative transketolase central region
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  • ADU85986.1
  • tiaE
 13260 - 14006 (-) putative thioesterase
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  • ADU85987.1
  • tiaF
 14189 - 15220 (+) putative 3-oxoacyl-ACP synthase III
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  • ADU85988.1
  • tiaB
 15220 - 20349 (+) putative iterative type I polyketide synthase
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  • ADU85989.1
  • tiaG2
 20351 - 21772 (+) putative glycosyltransferase
  • Tailoring (Glycosylation)
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  • ADU85990.1
  • tiaS4
 21789 - 22820 (+) putative GDP-D-mannose dehydratase
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  • ADU85991.1
  • tiaT1
 22880 - 24505 (-) putative membrane transport protein
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  • ADU85992.1
  • tiaI
 24502 - 26853 (-) putative ATP-dependent DNA helicase
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  • ADU85993.1
  • tiaJ
 27187 - 28398 (+) putative 3-hydroxybutyryl-CoA dehydrogenase
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  • ADU85994.1
  • tiaK
 28395 - 29759 (+) putative crotonyl CoA reductase
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  • ADU85995.1
  • tiaL
 29770 - 31200 (+) putative propionyl-CoA carboxylase
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  • ADU85996.1
  • tiaP1
 31301 - 32479 (-) putative cytochrome P450 hydroxylase
  • Tailoring (Hydroxylation)
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  • ADU85997.1
  • tiaS5
 33022 - 34347 (+) putative sugar O-methyltransferase
  • Tailoring (Methylation)
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  • ADU85998.1
  • tiaR1
 34415 - 37186 (+) putative LuxR class regulator
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  • ADU85999.1
  • tiaM
 37305 - 38789 (+) putative tryptophan halogenase
  • Tailoring (Halogenation)
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  • ADU86000.1
  • tiaS6
 38882 - 40021 (+) putative O-acyltransferase
  • Tailoring (Acylation)
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  • ADU86001.1
  • tiaP2
 40105 - 41304 (-) putative cytochrome P450
  • Tailoring (Hydroxylation)
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  • ADU86002.1
  • tiaA1
 41491 - 57180 (+) putative modular polyketide synthase
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  • ADU86003.1
  • tiaA2
 57186 - 66803 (+) putative modular polyketide synthase
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  • ADU85981.1
  • tiaA3
 66829 - 71337 (+) putative modular polyketide synthase
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  • ADU86004.1
  • tiaA4
 71361 - 81746 (+) putative modular polyketide synthase
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  • ADU86005.1
  • tiaN
 82097 - 83296 (+) putative enoyl-CoA hydratase/isomerase
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  • ADU86006.1
  • tiaT2
 83304 - 84590 (+) putative membrane antiporter
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  • ADU86007.1
  • tiaT3
 84642 - 85955 (-) putative ABC transporter-related protein
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  • ADU86008.1
  • tiaT4
 86003 - 87757 (-) putative binding-protein-dependent transport systems inner membrane component
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  • ADU86009.1
  • tiaR2
 88114 - 88527 (+) putative ArsR family transcriptional regulator
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Polyketide-specific information
Subclass Macrolide
Starter unit Ethylmalonyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
tiaE Synthase subclass: Modular type I
Thioesterases:
  • tiaE (Type II)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: YU43TGF6RSKW2WJOQIFYBQO4, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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