BGC0000165: tiacumicin B biosynthetic gene cluster from Dactylosporangium aurantiacum subsp. hamdenensis
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Location: 6,044 - 88,527 nt. (total: 82,484 nt).
This entry is originally from NCBI GenBank HQ011923.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000165
Short description tiacumicin B biosynthetic gene cluster from Dactylosporangium aurantiacum subsp. hamdenensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
HQ011923.1
6044 - 88527
via Knock-out studies, Enzymatic assays
Compounds
  • tiacumicin B
Species Dactylosporangium aurantiacum subsp. hamdenensis [taxonomy]
References
Chemical products information
tiacumicin B [synonyms: PAR101, fidaxomicin, clostomycin B1, lipiarmicin, difimicin, OPT-80, lipiarmycin A3, dificid, dificlir] Evidence: X-ray crystallography [1], NMR [4]
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C52H74Cl2O18
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADU86026.1
  • tiaG1
 6044 - 7441 (-) putative glycosyltransferase
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    • ADU85982.1
    • tiaS1
    		 7492 - 8508 (-) putative GDP-D-mannose dehydratase
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      • ADU85983.1
      • tiaS2
      		 8534 - 9742 (-) putative C-methyltransferase
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        • ADV15440.1
        • tiaS3
        		 9787 - 10785 (-) GDP-mannose 4,6-dehydratase
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          • ADU85984.1
          • tiaC
          		 11219 - 12280 (+) putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit
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            • ADU85985.1
            • tiaD
            		 12277 - 13254 (+) putative transketolase central region
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              • ADU85986.1
              • tiaE
              		 13260 - 14006 (-) putative thioesterase
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                • ADU85987.1
                • tiaF
                		 14189 - 15220 (+) putative 3-oxoacyl-ACP synthase III
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                  • ADU85988.1
                  • tiaB
                  		 15220 - 20349 (+) putative iterative type I polyketide synthase
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                    • ADU85989.1
                    • tiaG2
                    		 20351 - 21772 (+) putative glycosyltransferase
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                      • ADU85990.1
                      • tiaS4
                      		 21789 - 22820 (+) putative GDP-D-mannose dehydratase
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                        • ADU85991.1
                        • tiaT1
                        		 22880 - 24505 (-) putative membrane transport protein
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                          • ADU85992.1
                          • tiaI
                          		 24502 - 26853 (-) putative ATP-dependent DNA helicase
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                            • ADU85993.1
                            • tiaJ
                            		 27187 - 28398 (+) putative 3-hydroxybutyryl-CoA dehydrogenase
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                              • ADU85994.1
                              • tiaK
                              		 28395 - 29759 (+) putative crotonyl CoA reductase
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                                • ADU85995.1
                                • tiaL
                                		 29770 - 31200 (+) putative propionyl-CoA carboxylase
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                                  • ADU85996.1
                                  • tiaP1
                                  		 31301 - 32479 (-) putative cytochrome P450 hydroxylase
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                                    • ADU85997.1
                                    • tiaS5
                                    		 33022 - 34347 (+) putative sugar O-methyltransferase
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                                      • ADU85998.1
                                      • tiaR1
                                      		 34415 - 37186 (+) putative LuxR class regulator
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                                        • ADU85999.1
                                        • tiaM
                                        		 37305 - 38789 (+) putative tryptophan halogenase
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                                          • ADU86000.1
                                          • tiaS6
                                          		 38882 - 40021 (+) putative O-acyltransferase
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                                            • ADU86001.1
                                            • tiaP2
                                            		 40105 - 41304 (-) putative cytochrome P450
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                                              • ADU86002.1
                                              • tiaA1
                                              		 41491 - 57180 (+) putative modular polyketide synthase
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                                                • ADU86003.1
                                                • tiaA2
                                                		 57186 - 66803 (+) putative modular polyketide synthase
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                                                  • ADU85981.1
                                                  • tiaA3
                                                  		 66829 - 71337 (+) putative modular polyketide synthase
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                                                    • ADU86004.1
                                                    • tiaA4
                                                    		 71361 - 81746 (+) putative modular polyketide synthase
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                                                      • ADU86005.1
                                                      • tiaN
                                                      		 82097 - 83296 (+) putative enoyl-CoA hydratase/isomerase
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                                                        • ADU86006.1
                                                        • tiaT2
                                                        		 83304 - 84590 (+) putative membrane antiporter
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                                                          • ADU86007.1
                                                          • tiaT3
                                                          		 84642 - 85955 (-) putative ABC transporter-related protein
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                                                            • ADU86008.1
                                                            • tiaT4
                                                            		 86003 - 87757 (-) putative binding-protein-dependent transport systems inner membrane component
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                                                              • ADU86009.1
                                                              • tiaR2
                                                              		 88114 - 88527 (+) putative ArsR family transcriptional regulator
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                                                                Biosynthesis information
                                                                Annotation changelog

                                                                Entry version: next

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2024-05-14
                                                                MIBiG v4 annotathon
                                                                • (ID: 7ZPV7YL7LI6WACA7MW4GA2DX)
                                                                • (ID: HSOJFFPY5IUT4HBQLSN7DGJX)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 3

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-10-07
                                                                Update chemical activity to schema version 2.11
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 2

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2019-10-16
                                                                Migrated from v1.4
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                2019-10-16
                                                                Updated compound(s) information (NPAtlas curation)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2015-06-12
                                                                Submitted
                                                                • (ID: YU43TGF6RSKW2WJOQIFYBQO4)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                Detailed domain annotation
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