Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000165.1:
Cluster 1Polyketide182484

BGC0000165, tiacumicin B biosynthetic gene cluster from Dactylosporangium aurantiacum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: tiacumicin B
PubChem ID: 70678896
SMILES string: Copy to clipboard
Molecular formula: C52H74Cl2O18
Average molecular mass: 1058.046 Da
Molecular activity: Antibacterial
Molecular target: RNA polymerase

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Ethylmalonyl-CoA
Thioesterase type:
Type II
Release / cyclization type:
Macrolactonization

Gene cluster description

tiacumicin B (BGC0000165). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank HQ011923, positions 6044-88527. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Changsheng Zhang (South China Sea Institute of Oceanology)

Literature references

1. Xiao Y et al. (2011) Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase. J Am Chem Soc 133(4):1092-105. doi: 10.1021/ja109445q. Epub 2010 Dec
2. Niu S et al. (2011) Characterization of a sugar-O-methyltransferase TiaS5 affords new Tiacumicin analogues with improved antibacterial properties and reveals substrate promiscuity. Chembiochem 12(11):1740-8. doi: 10.1002/cbic.201100129. Epub 2011