BGC0000166: tylactone biosynthetic gene cluster from Streptomyces fradiae
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Location: 1 - 43,280 nt. (total: 43,280 nt).
This entry is originally from NCBI GenBank U78289.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
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General
Compounds
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Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000166
Short description tylactone biosynthetic gene cluster from Streptomyces fradiae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
U78289.1
via
Compounds
  • tylactone
Species Streptomyces fradiae [taxonomy]
References
Chemical products information
tylactone Evidence:
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C23H38O5
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAB66504.1
  • tylG
 816 - 14234 (+) tylactone synthase starter module and modules 1 & 2
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    • AAB66505.1
    • tylG_rename1
    		 14351 - 19945 (+) tylactone synthase module 3
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      • AAB66506.1
      • tylG_rename2
      		 20010 - 31199 (+) tylactone synthase modules 4 & 5
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        • AAB66507.1
        • tylG_rename3
        		 31232 - 36067 (+) tylactone synthase module 6
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          • AAB66508.1
          • tylG_rename4
          		 36249 - 41774 (+) tylactone synthase module 7
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            • AAB66509.1
            • tylG_rename5
            		 41771 - 43057 (+) tyl ORFX
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              • AAB66510.1
              • tylG_rename6
              		 43098 - >43280 (+) tyl ORFY
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                Biosynthesis information
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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                Modifications to original record
                • renamed CDS with name tylG at [14350:19945](+) to tylG_rename1 to avoid duplicates
                • renamed CDS with name tylG at [20009:31199](+) to tylG_rename2 to avoid duplicates
                • renamed CDS with name tylG at [31231:36067](+) to tylG_rename3 to avoid duplicates
                • renamed CDS with name tylG at [36248:41774](+) to tylG_rename4 to avoid duplicates
                • renamed CDS with name tylG at [41770:43057](+) to tylG_rename5 to avoid duplicates
                • renamed CDS with name tylG at [43097:>43280](+) to tylG_rename6 to avoid duplicates