BGC0000170 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000170 (Aspergillus niger ATCC 1015)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	45,340	High	yanuthone D	PKS

BGC0000170 - Region 1 - T1PKS

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Location: 1 - 45,340 nt. (total: 45,340 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 45,341
Label		BGC0000170

Tailoring functions

Oxidoreductases: oxidase oxygenase

ASPNIDRAFT_193092: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ASPNIDRAFT_44970: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

ASPNIDRAFT_54844: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: synthase

ASPNIDRAFT_44965: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000170.3	1.00	PKS	yanuthone D	Aspergillus niger ATCC 1015
BGC0001275.3	0.79	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.78	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.78	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002615.2	0.77	terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0001276.3	0.69	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000170.3	1.00	PKS	yanuthone D	Aspergillus niger ATCC 1015
BGC0001275.3	0.79	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.78	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.78	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002615.2	0.77	terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0001276.3	0.69	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 45340:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPNIDRAFT_44965: mmal

PKS_AT (586..877): mmal

ATSignature: Methylmalonyl-CoA, Malonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 75.0%; Malonyl-CoA: 75.0%; Ethylmalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 111.9
Ethylmalonyl-CoA: 94.8
Methoxymalonyl-CoA: 91.0
Isobutyryl-CoA: 67.1
Malonyl-CoA: 58.2
trans-1,2-CPDA: 46.4
Benzoyl-CoA: 44.0
Propionyl-CoA: 40.9
2-Methylbutyryl-CoA: 40.5
Acetyl-CoA: 31.8
fatty_acid: 30.0
CHC-CoA: 16.5
3-Methylbutyryl-CoA: 16.1
inactive: 10.4

Link to PARAS substrate predictor