Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000171.1:
Cluster 1Polyketide152580

BGC0000171, 9-methylstreptimidone biosynthetic gene cluster from Streptomyces himastatinicus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: 9-methylstreptimidone
SMILES string: Copy to clipboard
Molecular formula: C17H25NO4
Exact molecular mass: 307.18 Da (M+)
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Propionyl-CoA
Thioesterase type:
Type II
Release / cyclization type:
Other

Gene cluster description

9-methylstreptimidone (BGC0000171). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank FR878059, positions 4106-34419. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Jianhua Ju (South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS) 164 XinGang Road West Guangzhou 510301, China)

Literature references

1. Wang B et al. (2013) Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation. Org Lett 15(6):1278-81. doi: 10.1021/ol400224n. Epub 2013 Feb 25.