BGC0000171: 9-methylstreptimidone biosynthetic gene cluster from Streptomyces himastatinicus ATCC 53653
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Location: 1 - 52,580 nt. (total: 52,580 nt).
This entry is originally from NCBI GenBank FR878059.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000171
Short description 9-methylstreptimidone biosynthetic gene cluster from Streptomyces himastatinicus ATCC 53653
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
FR878059.1
via Knock-out studies
Compounds
  • 9-methylstreptimidone
Species Streptomyces himastatinicus ATCC 53653 [taxonomy]
References
Chemical products information
9-methylstreptimidone Evidence:
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C17H25N1O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCC21111.1
 1 - 1389 (-) putative peptide synthetase
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    • CCC21112.1
    		 1389 - 2429 (-) putative 3-dehydroquinate synthase
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      • CCC21113.1
      		 2426 - 3232 (-) putative Dhna-type fructose-1,6-bisphosphate aldolase
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        • CCC21114.1
        		 3487 - 4092 (+) putative tryptophan repressor binding protein
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          • CCC21115.1
          • smdA
          		 4106 - 5683 (+) drug resistance transporter
          • Transport
          • Knock-out
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          • CCC21116.1
          • smdB
          		 5637 - 6545 (+) lysr family transcriptional regulator
          • Regulation
          • Knock-out
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          • CCC21117.1
          • smdC
          		 6799 - 8133 (-) signal transduction histidine kinase
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            • CCC21118.1
            • smdD
            		 8130 - 8834 (-) two component transcriptional regulator
            • Regulation
            • Knock-out
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            • CCC21119.1
            • smdE
            		 8903 - 9667 (-) thioesterase
            • Scaffold biosynthesis
            • Knock-out
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            • CCC21120.1
            • smdF
            		 9983 - 10867 (+) malonyl coa-ACP transferase
            • Scaffold biosynthesis
            • Knock-out
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            • CCC21121.1
            • smdG
            		 10869 - 11126 (+) acyl carrier protein
            • Scaffold biosynthesis
            • Knock-out
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            • CCC21122.1
            • smdH
            		 11170 - 13161 (+) amidotransferase
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              • CCC21123.1
              • smdI
              		 13158 - 32300 (+) type-I polyketide synthases
              • Scaffold biosynthesis
              • Knock-out
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              • CCC21124.1
              • smdJ
              		 32300 - 32941 (+) putative flavoprotein decarboxylase
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                • CCC21125.1
                • smdK
                		 32938 - 34419 (+) putative 3-octaprenyl-4-hydroxybenzoate
                • Scaffold biosynthesis
                • Knock-out
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                • CCC21126.1
                		 34427 - 34969 (-) hypothetical protein
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                  • CCC21127.1
                  		 34986 - 37160 (-) hypothetical protein
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                    • CCC21128.1
                    		 37217 - 37678 (-) hypothetical protein
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                      • CCC21129.1
                      		 37798 - 39195 (-) putative monoxygenase
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                        • CCC21130.1
                        		 39195 - 40028 (-) putative ABC transporter inner membrane protein
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                          • CCC21131.1
                          		 40025 - 40912 (-) putative transporter permease
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                            • CCC21132.1
                            		 40919 - 42262 (-) putative ABC transporter extracellular membrane protein
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                              • CCC21133.1
                              		 42281 - 43489 (-) putative ABC transporter extracellular membrane protein
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                                • CCC21134.1
                                		 43528 - 44721 (-) putative acyl-CoA dehydrogenase
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                                  • CCC21135.1
                                  		 44718 - 45878 (-) putative alkanesulfonate monooxygenase
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                                    • CCC21136.1
                                    		 45915 - 47114 (-) putative acyl-CoA dehydrogenase
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                                      • CCC21137.1
                                      		 47121 - 47675 (-) putative NAD(P)H-dependent FMN reductase
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                                        • CCC21138.1
                                        		 47718 - 48935 (-) putative dibenzothiophene desulfurization enzyme C
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                                          • CCC21139.1
                                          		 48966 - 50105 (-) putative alkanesulfonate monooxyhenase
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                                            • CCC21140.1
                                            		 50634 - 51560 (+) putative LysR family transcriptional regulator
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                                              • CCC21141.1
                                              		 51547 - 52509 (-) putative G6PDH family F420-dependent oxidoreductase
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                                                Biosynthesis information
                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Updated bioactivity data
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2019-10-16
                                                Updated compound(s) information (NPAtlas curation)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-06-12
                                                Submitted
                                                • (ID: AADADFAEMFE2AOMR24EUYNFH)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Detailed domain annotation
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