BGC0000172 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000172 (Brevibacillus laterosporus PE36)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	transAT-PKS	1	47,812	Basiliskamide A/Basiliskamide B	PKS	100%

BGC0000172 - Region 1 - transAT-PKS

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Location: 1 - 47,812 nt. (total: 47,812 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 47,813
Label		BGC0000172

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000172	1.00	Polyketide	basiliskamide A, basiliskamide B	Brevibacillus laterosporus PE36
BGC0000846	0.27	Other	tabtoxin	Pseudomonas syringae
BGC0000885	0.24	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0002711	0.23	Polyketide	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000937	0.23	Other	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000887	0.23	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C
BGC0001880	0.22	RiPP	scytodecamide	Scytonema sp. UIC 10036
BGC0002473	0.22	NRP	propanochelin, butanochelin, pentanochelin	Acinetobacter bouvetii DSM 14964 = CIP 107468
BGC0001739	0.22	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0002056	0.22	NRP, Polyketide	peloruside A	sponge metagenome

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000172	1.00	Polyketide	basiliskamide A, basiliskamide B	Brevibacillus laterosporus PE36
BGC0000846	0.61	Other	tabtoxin	Pseudomonas syringae
BGC0000885	0.57	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0002711	0.56	Polyketide	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000937	0.56	Other	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000887	0.56	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C
BGC0001880	0.55	RiPP	scytodecamide	Scytonema sp. UIC 10036
BGC0002473	0.55	NRP	propanochelin, butanochelin, pentanochelin	Acinetobacter bouvetii DSM 14964 = CIP 107468
BGC0001739	0.55	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0002056	0.55	NRP, Polyketide	peloruside A	sponge metagenome

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 47812:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal) + (Me-ohmal) + (ohmal - ohmal - mal)
Non-colinear ordering:: P615_14890 + P615_14885 + P615_14880 + P615_14875

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

P615_14895

PKS_AT (7..295): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 43.6
inactive: 27.2
Methoxymalonyl-CoA: 12.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (335..613): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 75.5
inactive: 37.4
Propionyl-CoA: 26.8
Methoxymalonyl-CoA: 26.8
Methylmalonyl-CoA: 17.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

P615_14910

AMP-binding (19..411): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GTGMLAIAVK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)