BGC0000173: isobongkrekic acid biosynthetic gene cluster from Burkholderia gladioli
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Location: 1 - 67,546 nt. (total: 67,546 nt).
This entry is originally from NCBI GenBank JX173632.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000173
Short description isobongkrekic acid biosynthetic gene cluster from Burkholderia gladioli
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyene)
Loci NCBI GenBank: JX173632.1
Compounds
  • isobongkrekic acid
  • bongkrekic acid
Species Burkholderia gladioli [taxonomy]
References
Chemical products information
isobongkrekic acid
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C28H38O7
Chemical database entries
NPAtlas
bongkrekic acid
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C28H38O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFN27473.1
 1 - 1065 (+) putative regulator
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  • AFN27474.1
 2868 - 3371 (+) putative regulator
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  • AFN27475.1
  • bonL
 3781 - 5034 (+) cytochrome P-450 monooxygenase BonL
  • Tailoring (Carboxylation)
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  • AFN27476.1
  • bonJ
 5153 - 6166 (+) acyl transferase I BonJ
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  • AFN27477.1
  • bonK
 6650 - 7783 (+) acyl transferase II BonK
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  • AFN27478.1
  • bonF
 7851 - 9101 (+) beta-ketoacyl synthase BonF
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  • AFN27479.1
  • bonG
 9106 - 10380 (+) hydroxymethylglutaryl-coenzyme A synthase BonG
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  • AFN27480.1
  • bonA
 11410 - 35136 (+) pks BonA
  • Scaffold biosynthesis
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  • AFN27481.1
  • bonB
 35078 - 45826 (+) pks BonB
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  • AFN27482.1
  • bonC
 45853 - 50970 (+) pks BonC
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  • AFN27483.1
  • bonD
 51038 - 63328 (+) pks BonD
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  • AFN27484.1
  • bonH
 63448 - 64800 (+) enoyl-CoA hydratase BonH
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  • AFN27485.1
  • bonI
 65617 - 66366 (+) enoyl-CoA hydratase BonH
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  • AFN27486.1
  • bonM
 66740 - >67546 (+) O-methyltransferase BonM
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Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
bonD
+
bonC
+
bonB
+
bonA 		Synthase subclass: Modular type I
Module 0
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: bonA
Core domains: Acyltransferase, Thiolation (ACP/PCP)
Module 1
Genes: bonA
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Beta-branching
Module 2
Genes: bonA
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 3
Genes: bonA
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 4
Genes: bonA
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Genes: bonA
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Genes: bonA, bonB
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Non-canonical activity:
  • Skipped
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 7
Genes: bonB
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 8
Genes: bonB, bonC
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 9
Genes: bonC, bonD
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module 10
Genes: bonD
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 11
Genes: bonD
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Beta-branching
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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