BGC0000173: isobongkrekic acid biosynthetic gene cluster from Burkholderia gladioli
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Location: 1 - 67,546 nt. (total: 67,546 nt).
This entry is originally from NCBI GenBank JX173632.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000173
Short description isobongkrekic acid biosynthetic gene cluster from Burkholderia gladioli
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
JX173632.1
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • isobongkrekic acid
  • bongkrekic acid
Species Burkholderia gladioli [taxonomy]
References
Chemical products information
isobongkrekic acid Evidence:
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C28H38O7
Chemical database entries
NPAtlas
bongkrekic acid Evidence:
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C28H38O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFN27473.1
 1 - 1065 (+) putative regulator
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    • AFN27474.1
    		 2868 - 3371 (+) putative regulator
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      • AFN27475.1
      • bonL
      		 3781 - 5034 (+) cytochrome P-450 monooxygenase BonL
      • Tailoring
      • Knock-out
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      • AFN27476.1
      • bonJ
      		 5153 - 6166 (+) acyl transferase I BonJ
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        • AFN27477.1
        • bonK
        		 6650 - 7783 (+) acyl transferase II BonK
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          • AFN27478.1
          • bonF
          		 7851 - 9101 (+) beta-ketoacyl synthase BonF
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            • AFN27479.1
            • bonG
            		 9106 - 10380 (+) hydroxymethylglutaryl-coenzyme A synthase BonG
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              • AFN27480.1
              • bonA
              		 11410 - 35136 (+) pks BonA
              • Scaffold biosynthesis
              • Knock-out
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              • AFN27481.1
              • bonB
              		 35078 - 45826 (+) pks BonB
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                • AFN27482.1
                • bonC
                		 45853 - 50970 (+) pks BonC
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                  • AFN27483.1
                  • bonD
                  		 51038 - 63328 (+) pks BonD
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                    • AFN27484.1
                    • bonH
                    		 63448 - 64800 (+) enoyl-CoA hydratase BonH
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                      • AFN27485.1
                      • bonI
                      		 65617 - 66366 (+) enoyl-CoA hydratase BonH
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                        • AFN27486.1
                        • bonM
                        		 66740 - >67546 (+) O-methyltransferase BonM
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          0
                          Type
                          pks-modular-starter
                          Genes
                          bonA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, carrier (ACP)
                          Name
                          1
                          Type
                          pks-trans-at
                          Genes
                          bonA
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, carrier (ACP)
                          Name
                          2
                          Type
                          pks-trans-at
                          Genes
                          bonA
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
                          Name
                          3
                          Type
                          pks-trans-at
                          Genes
                          bonA
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, carrier (ACP)
                          Name
                          4
                          Type
                          pks-trans-at
                          Genes
                          bonA
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          5
                          Type
                          pks-trans-at
                          Genes
                          bonA
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, carrier (ACP)
                          Name
                          6
                          Type
                          pks-trans-at
                          Genes
                          bonA bonB
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, dehydratase, carrier (ACP)
                          Name
                          7
                          Type
                          pks-trans-at
                          Genes
                          bonB
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          8
                          Type
                          pks-trans-at
                          Genes
                          bonB bonC
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          9
                          Type
                          pks-trans-at
                          Genes
                          bonC bonD
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
                          Name
                          10
                          Type
                          pks-trans-at
                          Genes
                          bonD
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                          Name
                          11
                          Type
                          pks-trans-at
                          Genes
                          bonD
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, carrier (ACP)
                          Annotation changelog

                          Entry version: 4

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Merged cross-CDS PKS modules
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Updated bioactivity data
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated compound(s) information (NPAtlas curation)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2015-06-12
                          Submitted
                          • (ID: F65XGYSSLMUEJC2Q4T3BLCPS)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
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