BGC0000174 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000174 (Candidatus Endobugula sertula (Bugula neritina bacterial symbiont))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	transAT-PKS-like	1	72,988	High	bryostatin	PKS

BGC0000174 - Region 1 - transAT-PKS-like

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Location: 1 - 72,988 nt. (total: 72,988 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,989
Label		BGC0000174

Tailoring functions

Oxidoreductases: dehydrogenase

bryB: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

bryC: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

bryD: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: phosphatase

bryA: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000174.5	0.86	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001644.4	0.56	PKS	lacunalide A, lacunalide B	Gynuella sunshinyii YC6258
BGC0001795.3	0.54	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0001069.5	0.52	NRPS, PKS	chivosazol	Sorangium cellulosum
BGC0001186.4	0.52	PKS	misakinolide A	Candidatus Entotheonella serta
BGC0000184.5	0.51	PKS	sorangicin A	Sorangium cellulosum
BGC0001025.5	0.51	NRPS, PKS	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001031.5	0.51	NRPS, PKS	oocydin A	Serratia marcescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000174.5	0.86	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001644.4	0.56	PKS	lacunalide A, lacunalide B	Gynuella sunshinyii YC6258
BGC0001795.3	0.54	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0001069.5	0.52	NRPS, PKS	chivosazol	Sorangium cellulosum
BGC0001186.4	0.52	PKS	misakinolide A	Candidatus Entotheonella serta
BGC0000184.5	0.51	PKS	sorangicin A	Sorangium cellulosum
BGC0001025.5	0.51	NRPS, PKS	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001031.5	0.51	NRPS, PKS	oocydin A	Serratia marcescens

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

Predicted core structure(s)

For candidate cluster 1, location 0 - 72988:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - ccmal - ohmal - mal) + (ccmal - Me-mal - ohmal - mal) + (mal - mal - ccmal) + (ohmal) + (ohmal - ohmal - mal)
Non-colinear ordering:: bryB + bryC + bryX + bryD + bryA

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