Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000174.1:
Cluster 1Polyketide172988

BGC0000174, bryostatin biosynthetic gene cluster from Candidatus Endobugula. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: bryostatin
PubChem ID: 25235992
SMILES string: Copy to clipboard
Molecular formula: C47H68O17
Average molecular mass: 905.044 Da

Class-specific details

Biosynthetic class(es):
Polyketide synthase subclass:
Trans-AT type I

Gene cluster description

bryostatin (BGC0000174). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank DQ889941. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Literature references

1. Hildebrand M et al. (2004) bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chem Biol 11(11):1543-52. doi: 10.1016/j.chembiol.2004.08.018.
2. Wharton J et al. (1991 TI) Localization of endothelin binding sites and endothelin-like immunoreactivity in human fetal heart. J Cardiovasc Pharmacol 17 Suppl 7:S378-84.