Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000175.1:
Cluster 1Polyketide145467

BGC0000175, cycloheximide / actiphenol biosynthetic gene cluster from Streptomyces sp. YIM. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cycloheximide
PubChem ID: 6197
SMILES string: Copy to clipboard
Molecular formula: C15H23NO4
Average molecular mass: 281.352 Da
Molecular activity: Inhibitor
Molecular target: ribosome E site

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Malonyl-CoA
Trans-acyltransferases in this cluster:
AFO59863.1

Gene cluster description

cycloheximide / actiphenol (BGC0000175). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank JX014302, positions 2506-38720. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

No core peptides found.

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Xiaohui Yan (The Scripps Research Institute)

Literature references

1. Yin M et al. (2014) Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Org Lett 16(11):3072-5. doi: 10.1021/ol501179w. Epub 2014 May 9.
2. Huang SX et al. (2011) Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141. J Antibiot (Tokyo) 64(1):163-6. doi: 10.1038/ja.2010.150. Epub 2010 Dec