BGC0000175: cycloheximide biosynthetic gene cluster from Streptomyces sp. YIM 56141
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Location: 1 - 45,467 nt. (total: 45,467 nt).
This entry is originally from NCBI GenBank JX014302.1.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
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Polyketide
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000175
Short description cycloheximide biosynthetic gene cluster from Streptomyces sp. YIM 56141
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: JX014302.1
Compounds
  • cycloheximide
Species Streptomyces sp. YIM 56141 [taxonomy]
References
Chemical products information
cycloheximide
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C15H23N1O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFO59859.1
 70 - 819 (+) hypothetical protein
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  • AFO59860.1
 971 - 1747 (+) hypothetical protein
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  • AFO59861.1
 2031 - 2456 (+) hypothetical protein
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  • AFO59862.1
 2506 - 5877 (-) ChxA
  • Regulation
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  • AFO59863.1
 6294 - 7169 (+) ChxB
  • Scaffold biosynthesis
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  • AFO59864.1
 7173 - 7430 (+) ChxC
  • Precursor biosynthesis
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  • AFO59865.1
 7447 - 9483 (+) amidotransferase
  • Precursor biosynthesis
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  • AFO59866.1
 9480 - 30236 (+) ChxE
  • Scaffold biosynthesis
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  • AFO59867.1
 30233 - 31192 (+) ChxF
  • Regulation
Sequence-based prediction
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  • AFO59868.1
 31680 - 32774 (-) the OYE family of flavoprotein oxidoreductase
  • Tailoring (Unknown)
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  • AFO59869.1
 33103 - 33891 (+) ChxH
  • Tailoring (Unknown)
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  • AFO59870.1
 33978 - 35171 (+) ChxI
  • Tailoring (Unknown)
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  • AFO59871.1
 35274 - 38720 (+) three-domain carboxylic acid reductase
  • Tailoring (Reduction)
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  • AFO59872.1
 38774 - 39163 (+) hypothetical protein
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  • AFO59873.1
 39752 - 42409 (+) hypothetical protein
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  • AFO59874.1
 43054 - 43290 (-) hypothetical protein
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  • AFO59875.1
 43925 - 44137 (+) hypothetical protein
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  • AFO59876.1
 44766 - 45029 (-) hypothetical protein
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
AFO59863.1 Synthase subclass: Trans-AT type I
Trans-acyltansferases: AFO59863.1
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: E2T2HCM4X7QXVS4LL4JVBPPK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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