BGC0000175: cycloheximide biosynthetic gene cluster from Streptomyces sp. YIM 56141
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Location: 1 - 45,467 nt. (total: 45,467 nt).
This entry is originally from NCBI GenBank JX014302.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000175
Short description cycloheximide biosynthetic gene cluster from Streptomyces sp. YIM 56141
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Trans-AT type I)
Loci
JX014302.1
via Knock-out studies
Compounds
  • cycloheximide
Species Streptomyces sp. YIM 56141 [taxonomy]
References
Chemical products information
cycloheximide Evidence:
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C15H23N1O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFO59859.1
 70 - 819 (+) hypothetical protein
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    • AFO59860.1
    		 971 - 1747 (+) hypothetical protein
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      • AFO59861.1
      		 2031 - 2456 (+) hypothetical protein
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        • AFO59862.1
        		 2506 - 5877 (-) ChxA
        • Regulation
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        • AFO59863.1
        		 6294 - 7169 (+) ChxB
        • Scaffold biosynthesis
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        • AFO59864.1
        		 7173 - 7430 (+) ChxC
        • Precursor biosynthesis
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        • AFO59865.1
        		 7447 - 9483 (+) amidotransferase
        • Precursor biosynthesis
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        • AFO59866.1
        		 9480 - 30236 (+) ChxE
        • Scaffold biosynthesis
        • Knock-out
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        • AFO59867.1
        		 30233 - 31192 (+) ChxF
        • Regulation
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        • AFO59868.1
        		 31680 - 32774 (-) the OYE family of flavoprotein oxidoreductase
        • Tailoring
        • Knock-out
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        • AFO59869.1
        		 33103 - 33891 (+) ChxH
        • Tailoring
        • Activity assay
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        • AFO59870.1
        		 33978 - 35171 (+) ChxI
        • Tailoring
        • Knock-out
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        • AFO59871.1
        		 35274 - 38720 (+) three-domain carboxylic acid reductase
        • Tailoring
        • Knock-out
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        • AFO59872.1
        		 38774 - 39163 (+) hypothetical protein
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          • AFO59873.1
          		 39752 - 42409 (+) hypothetical protein
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            • AFO59874.1
            		 43054 - 43290 (-) hypothetical protein
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              • AFO59875.1
              		 43925 - 44137 (+) hypothetical protein
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                • AFO59876.1
                		 44766 - 45029 (-) hypothetical protein
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                  Biosynthesis information
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Updated bioactivity data
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: E2T2HCM4X7QXVS4LL4JVBPPK)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
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