BGC0000177: iso-migrastatin biosynthetic gene cluster from Streptomyces platensis subsp. rosaceus
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Location: 1 - 53,336 nt. (total: 53,336 nt).
This entry is originally from NCBI GenBank GQ274953.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000177
Short description iso-migrastatin biosynthetic gene cluster from Streptomyces platensis subsp. rosaceus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
GQ274953.1
via Knock-out studies, Heterologous expression
Compounds
  • iso-migrastatin
  • migrastatin
  • dorrigocin A
  • dorrigocin B
  • 13-epi-dorrigocin A
Species Streptomyces platensis subsp. rosaceus [taxonomy]
References
Chemical products information
iso-migrastatin Evidence:
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C27H39N1O7
Chemical database entries
NPAtlas
PubCHEM
ChEMBL
migrastatin Evidence:
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C27H39N1O7
Chemical database entries
NPAtlas
PubCHEM
dorrigocin A Evidence:
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C27H41N1O8
Chemical database entries
NPAtlas
PubCHEM
dorrigocin B Evidence:
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C27H41N1O8
Chemical database entries
NPAtlas
PubCHEM
13-epi-dorrigocin A Evidence:
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C27H41N1O8
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACY01386.1
 1 - 3654 (-) transcriptional regulator
  • Regulation
  • Knock-out
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  • ACY01387.1
 4026 - 5615 (+) trans-acting acyl transferase/thioesterase fusion protein
  • Scaffold biosynthesis
  • Knock-out
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  • ACY01388.1
 5701 - 5952 (+) acyl carrier protein
  • Scaffold biosynthesis
  • Knock-out
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  • ACY01389.1
 5957 - 7927 (+) amidotransferase
  • Tailoring
  • Knock-out
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  • ACY01390.1
 7943 - 17521 (+) AT-less polyketide synthase
  • Scaffold biosynthesis
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  • ACY01391.1
 17568 - 41648 (+) AT-less polyketide synthase
  • Scaffold biosynthesis
  • Knock-out
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  • ACY01392.1
 41705 - 47566 (+) AT-less polyketide synthase
  • Scaffold biosynthesis
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  • ACY01393.1
 47568 - 49823 (+) trans-acting acyl transferase/oxidoreductase fusion protein
  • Scaffold biosynthesis
  • Knock-out
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  • ACY01394.1
 49855 - 50871 (+) oxidoreductase
  • Tailoring
  • Knock-out
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  • ACY01395.1
 51167 - 52012 (+) O-methyl transferase
  • Tailoring
  • Knock-out
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  • ACY01396.1
 52125 - 53336 (+) hydroxylase
  • Tailoring
  • Knock-out
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Biosynthesis information

Biosynthetic modules

Name
0
Type
pks-trans-at-starter
Genes
ACY01388.1
Substrates
Integrated Monomers
Domains
carrier (ACP)
Name
1
Type
pks-trans-at
Genes
ACY01390.1
Substrates
Integrated Monomers
Domains
ketosynthase, dehydratase, ketoreductase, carrier (ACP)
Name
2
Type
pks-trans-at
Genes
ACY01390.1
Substrates
Integrated Monomers
Domains
ketosynthase, branching, carrier (ACP)
Name
3
Type
pks-trans-at
Genes
ACY01390.1 ACY01391.1
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, carrier (ACP)
Name
4
Type
pks-trans-at
Genes
ACY01391.1
Substrates
Integrated Monomers
Domains
ketosynthase, carrier (ACP)
Name
5
Type
pks-trans-at
Genes
ACY01391.1
Substrates
Integrated Monomers
Domains
ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
Name
6
Type
pks-trans-at
Genes
ACY01391.1
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
Name
7
Type
pks-trans-at
Genes
ACY01391.1
Substrates
Integrated Monomers
Domains
ketosynthase, carrier (ACP)
Name
8
Type
pks-trans-at
Genes
ACY01391.1
Substrates
Integrated Monomers
Domains
ketosynthase, dehydratase, ketoreductase, carrier (ACP), carrier (ACP)
Name
9
Type
pks-trans-at
Genes
ACY01391.1 ACY01392.1
Substrates
Integrated Monomers
Domains
ketosynthase, dehydratase, carrier (ACP)
Name
10
Type
pks-trans-at
Genes
ACY01392.1
Substrates
Integrated Monomers
Domains
ketosynthase, dehydratase, ketoreductase, carrier (ACP)
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Merged cross-CDS PKS modules
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Corrected gene identifiers
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Updated bioactivity data
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2019-10-16
Updated compound(s) information (NPAtlas curation)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: HPZ6LL7T2WJIC44FKRYGWFQ6)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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