BGC0000178: elansolid A1 biosynthetic gene cluster from Chitinophaga sancti
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Location: 1 - 78,240 nt. (total: 78,240 nt).
This entry is originally from NCBI GenBank HQ680975.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000178
Short description elansolid A1 biosynthetic gene cluster from Chitinophaga sancti
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: HQ680975.1
Compounds
  • elansolid A1
Species Chitinophaga sancti [taxonomy]
References
Chemical products information
elansolid A1
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C38H52O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEC04346.1
 40 - 1314 (-) major facilitator superfamily protein
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  • AEC04347.1
  • elaA
 1734 - 2258 (+) NusG antitermination factor
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  • AEC04348.1
  • elaB
 2293 - 4662 (+) PfaD family protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04349.1
  • elaC
 4683 - 5684 (+) acyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04350.1
  • elaD
 5688 - 5963 (+) hypothetical protein
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  • AEC04351.1
  • elaE
 5995 - 6240 (+) acyl carrier protein
  • Tailoring (Methylation)
Sequence-based prediction
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  • AEC04352.1
  • elaF
 6221 - 7450 (+) beta-ketoacyl acyl carrier protein synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04353.1
  • elaG
 7518 - 8780 (+) cytochrome P450
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AEC04354.1
  • elaH
 8805 - 9416 (+) hypothetical protein
  • Regulation
Sequence-based prediction
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  • AEC04355.1
  • elaI
 9455 - 10126 (+) putative chorismate lyase
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  • AEC04356.1
  • elaJ
 10135 - 18318 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04357.1
  • elaK
 18337 - 35742 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04358.1
  • elaL
 35776 - 37029 (+) hydroxymethylglutaryl-CoA synthase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AEC04359.1
  • elaM
 37017 - 37808 (+) enoyl-CoA hydratase/isomerase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AEC04360.1
  • elaN
 37815 - 38564 (+) enoyl-CoA hydratase/isomerase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AEC04361.1
  • elaO
 38576 - 43660 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04362.1
  • elaP
 43662 - 57434 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04363.1
  • elaQ
 57483 - 70769 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04364.1
  • elaR
 70776 - 76511 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEC04365.1
  • elaS
 76572 - 77399 (+) methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
elaC
+
elaB
+
elaO
+
elaJ
+
elaR
+
elaK
+
elaP
+
elaR
+
elaQ 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: elaC, elaB
Thioesterases:
  • elaR (Type I)
Module 0
Genes: elaJ
Core domains: CoA-ligase, Thiolation (ACP/PCP)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: elaJ
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Genes: elaJ, elaK
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 3
Genes: elaK
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 4
Genes: elaK
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Genes: elaK
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: elaO
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: elaO, elaP
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 8
Genes: elaP
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 9
Genes: elaP
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 10
Genes: elaP, elaQ
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 11
Genes: elaQ
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 12
Genes: elaQ
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 13
Genes: elaQ, elaR
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 14
Genes: elaR
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fixed incorrect gene id in annotations
  • Remove leading/trailing whitespace in gene identifiers
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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