Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000178.1:
Cluster 1Polyketide178240

BGC0000178, elansolid biosynthetic gene cluster from Chitinophaga sancti. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Elansolid A1
SMILES string: Copy to clipboard
Molecular formula: C37H48O6
Exact molecular mass: 589.3524 Da ([M+H]+)
Molecular activity: Antibacterial, Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
AEC04349.1,AEC04348.1
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
elaJ (AEC04356.1)
Module 0
AT specificity: Other
Evidence for specificity: Structure-based inference
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 2
AT specificity: None
Evidence for specificity: Unknown

elaK (AEC04357.1)
Module 2
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 3
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 4
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 5
AT specificity: None
Evidence for specificity: Unknown

elaO (AEC04361.1)
Module 6
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 7
AT specificity: None
Evidence for specificity: Unknown

elaP (AEC04362.1)
Module 7
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 8
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 9
AT specificity: None
Evidence for specificity: Unknown
Module 10
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group

elaQ (AEC04363.1)
Module 10
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 11
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 12
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 13
AT specificity: None
Evidence for specificity: Unknown

elaR (AEC04364.1)
Module 13
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 14
AT specificity: None
Evidence for specificity: Unknown

Gene cluster description

elansolid (BGC0000178). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank HQ680975, positions 1-78240. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Other
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Dehn R et al. (2011) Molecular basis of elansolid biosynthesis: evidence for an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition/macrolactonization. Angew Chem Int Ed Engl 50(17):3882-7. doi: 10.1002/anie.201006880.