BGC0000179: etnangien biosynthetic gene cluster from Sorangium cellulosum So ce56
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Location: 4,373,490 - 4,469,286 nt. (total: 95,797 nt).
This entry is originally from NCBI GenBank AM746676.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000179
Short description etnangien biosynthetic gene cluster from Sorangium cellulosum So ce56
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Trans-AT type I)
Loci
AM746676.1
4373490 - 4469286
via Knock-out studies
Compounds
  • etnangien
Species Sorangium cellulosum So ce56 [taxonomy]
References
Chemical products information
etnangien Evidence:
Copy SMILES
C49H76O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • sce3185
  • CAN93344.1
 4373490 - 4373804 (+) hypothetical protein
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    • sce3186
    • CAN93345.1
    • fabD1
    		 4373801 - 4374718 (+) malonyl CoA-acyl carrier protein transacylase
    • Activation / processing
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    • sce3187
    • CAN93346.1
    • asnB1
    		 4374706 - 4376670 (+) asparagine synthetase
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      • sce3188
      • CAN93347.1
      		 4376667 - 4392107 (+) Polyketide synthase
      • Scaffold biosynthesis
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      • sce3189
      • CAN93348.1
      		 4392104 - 4403590 (+) polyketide synthase
      • Precursor biosynthesis
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      • sce3190
      • CAN93349.1
      		 4403593 - 4414479 (+) polyketide synthase
      • Scaffold biosynthesis
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      • sce3191
      • CAN93350.1
      		 4414476 - 4429688 (+) polyketide synthase
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        • sce3192
        • CAN93351.1
        		 4429685 - 4440421 (+) polyketide synthase
        • Scaffold biosynthesis
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        • sce3193
        • CAN93352.1
        		 4440441 - 4458362 (+) polyketide synthase
        • Scaffold biosynthesis
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        • sce3194
        • CAN93353.1
        		 4458359 - 4459735 (+) MATE efflux family protein
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          • sce3195
          • CAN93354.1
          		 4459749 - 4461851 (+) malonyl CoA-acyl carrier protein transacylase
          • Activation / processing
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          • sce3196
          • CAN93355.1
          		 4462166 - 4462891 (+) hypothetical protein predicted by Glimmer/Critica
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            • sce3197
            • CAN93356.1
            		 4462937 - 4464595 (+) conserved carbohydrate-binding protein, Rhs family
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              • sce3198
              • CAN93357.1
              		 4464779 - 4465315 (+) hypothetical protein predicted by Glimmer/Critica
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                • sce3199
                • CAN93358.1
                		 4465312 - 4468080 (+) hypothetical protein predicted by Glimmer/Critica
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                  • sce3200
                  • CAN93359.1
                  		 4468402 - 4469286 (+) hypothetical protein
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    1
                    Type
                    pks-trans-at
                    Genes
                    sce3188
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, carrier (ACP)
                    Name
                    2
                    Type
                    pks-trans-at
                    Genes
                    sce3188
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    3
                    Type
                    pks-trans-at
                    Genes
                    sce3188
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                    Name
                    4
                    Type
                    pks-trans-at
                    Genes
                    sce3188 sce3189
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                    Name
                    5
                    Type
                    pks-trans-at
                    Genes
                    sce3189
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                    Name
                    6
                    Type
                    pks-trans-at
                    Genes
                    sce3189
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, carrier (ACP)
                    Name
                    7
                    Type
                    pks-trans-at
                    Genes
                    sce3189 sce3190
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    8
                    Type
                    pks-trans-at
                    Genes
                    sce3190
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    9
                    Type
                    pks-trans-at
                    Genes
                    sce3190
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    10
                    Type
                    pks-trans-at
                    Genes
                    sce3190 sce3191
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                    Name
                    11
                    Type
                    pks-trans-at
                    Genes
                    sce3191
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    12
                    Type
                    pks-trans-at
                    Genes
                    sce3191
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, methyltransferase, carrier (ACP)
                    Name
                    13
                    Type
                    pks-trans-at
                    Genes
                    sce3191
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    14
                    Type
                    pks-trans-at
                    Genes
                    sce3191 sce3192
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, dehydratase, carrier (ACP)
                    Name
                    15
                    Type
                    pks-trans-at
                    Genes
                    sce3192
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    16
                    Type
                    pks-trans-at
                    Genes
                    sce3192 sce3193
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, dehydratase, enoylreductase, methyltransferase, carrier (ACP)
                    Name
                    17
                    Type
                    pks-trans-at
                    Genes
                    sce3193
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    18
                    Type
                    pks-trans-at
                    Genes
                    sce3193
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
                    Name
                    19
                    Type
                    pks-trans-at
                    Genes
                    sce3193
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, ketoreductase, carrier (ACP)
                    Name
                    20
                    Type
                    pks-trans-at
                    Genes
                    sce3193
                    Substrates
                    Integrated Monomers
                    Domains
                    ketosynthase, carrier (ACP)
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Corrected gene identifiers
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Merged cross-CDS PKS modules
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Corrected PKS module 11 activity based on reference paper
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2019-10-16
                    Updated compound(s) information (NPAtlas curation)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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