Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000179.1:
Cluster 1Polyketide195797

BGC0000179, etnangien biosynthetic gene cluster from Sorangium cellulosum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Etnangien
SMILES string: Copy to clipboard
Molecular formula: C49H76O11
Exact molecular mass: 841.546 Da ([M+H]+)
Molecular activity: Other
Molecular target: retroviral DNA polymerase

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
SCE3186,SCE3195
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
etnD (CAN93347.1)
Module 1
AT specificity: None
Evidence for specificity: Unknown
Module 2
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 3
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 4
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group

etnE (sce3189)
Module 4
AT specificity: None
Evidence for specificity: Unknown
Module 5
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 6
AT specificity: None
Evidence for specificity: Unknown
Module 7
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group

etnF (sce3190)
Module 7
AT specificity: None
Evidence for specificity: Unknown
Module 8
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 9
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 10
AT specificity: None
Evidence for specificity: Unknown

etnG (ctg1_orf00032)
Module 10
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 11
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module is skipped
Evidence for skipping: Unknown
Module 12
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 13
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 14
AT specificity: None
Evidence for specificity: Unknown
Module is skipped
Evidence for skipping: Unknown

etnH (CAN93351.1)
Module 14
AT specificity: None
Evidence for specificity: Unknown
Module is skipped
Evidence for skipping: Structure-based inference
Module 15
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 16
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation

etnI (sce3193)
Module 16
AT specificity: None
Evidence for specificity: Unknown
Module 17
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 18
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 19
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 20
AT specificity: None
Evidence for specificity: Unknown
Module is skipped
Evidence for skipping: Structure-based inference

Gene cluster description

etnangien (BGC0000179). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AM746676, positions 1-106829. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Menche D et al. (2008) Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum. J Am Chem Soc 130(43):14234-43. doi: 10.1021/ja804194c. Epub 2008