BGC0000179: etnangien biosynthetic gene cluster from Sorangium cellulosum So ce56
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Location: 4,373,490 - 4,469,286 nt. (total: 95,797 nt).
This entry is originally from NCBI GenBank AM746676.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000179
Short description etnangien biosynthetic gene cluster from Sorangium cellulosum So ce56
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AM746676.1
Compounds
  • etnangien
Species Sorangium cellulosum So ce56 [taxonomy]
References
Chemical products information
etnangien
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C49H76O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • sce3185
  • CAN93344.1
 4373490 - 4373804 (+) hypothetical protein
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  • sce3186
  • CAN93345.1
  • fabD1
 4373801 - 4374718 (+) malonyl CoA-acyl carrier protein transacylase
  • Activation / processing
Sequence-based prediction
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  • sce3187
  • CAN93346.1
  • asnB1
 4374706 - 4376670 (+) asparagine synthetase
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  • sce3188
  • CAN93347.1
 4376667 - 4392107 (+) Polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • sce3189
  • CAN93348.1
 4392104 - 4403590 (+) polyketide synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • sce3190
  • CAN93349.1
 4403593 - 4414479 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • sce3191
  • CAN93350.1
 4414476 - 4429688 (+) polyketide synthase
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  • sce3192
  • CAN93351.1
 4429685 - 4440421 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • sce3193
  • CAN93352.1
 4440441 - 4458362 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • sce3194
  • CAN93353.1
 4458359 - 4459735 (+) MATE efflux family protein
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  • sce3195
  • CAN93354.1
 4459749 - 4461851 (+) malonyl CoA-acyl carrier protein transacylase
  • Activation / processing
Sequence-based prediction
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  • sce3196
  • CAN93355.1
 4462166 - 4462891 (+) hypothetical protein predicted by Glimmer/Critica
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  • sce3197
  • CAN93356.1
 4462937 - 4464595 (+) conserved carbohydrate-binding protein, Rhs family
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  • sce3198
  • CAN93357.1
 4464779 - 4465315 (+) hypothetical protein predicted by Glimmer/Critica
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  • sce3199
  • CAN93358.1
 4465312 - 4468080 (+) hypothetical protein predicted by Glimmer/Critica
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  • sce3200
  • CAN93359.1
 4468402 - 4469286 (+) hypothetical protein
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
sce3189
+
sce3193
+
sce3191
+
sce3192
+
sce3195
+
sce3190
+
fabD1
+
sce3188 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: fabD1, sce3195
Thioesterases:
  • sce3193 (Type I)
Module 1
Genes: sce3188
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 2
Genes: sce3188
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Genes: sce3188
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 4
Genes: sce3188, sce3189
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Genes: sce3189
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Genes: sce3189
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 7
Genes: sce3189, sce3190
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 8
Genes: sce3190
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 9
Genes: sce3190
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 10
Genes: sce3190, sce3191
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Genes: sce3191
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Non-canonical activity:
  • Skipped
Evidence for non-canonical activity:
  • Structure-based inference
Module 12
Genes: sce3191
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 13
Genes: sce3191
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 14
Genes: sce3191, sce3192
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Non-canonical activity:
  • Skipped
Evidence for non-canonical activity:
  • Structure-based inference
Module 15
Genes: sce3192
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 16
Genes: sce3192, sce3193
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP), Enoylreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 17
Genes: sce3193
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 18
Genes: sce3193
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 19
Genes: sce3193
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 20
Genes: sce3193
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Non-canonical activity:
  • Skipped
Evidence for non-canonical activity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
  • Merged cross-CDS PKS modules
  • Corrected PKS module 11 activity based on reference paper
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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