Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000180.1:
Cluster 1Polyketide126866

BGC0000180, legioliulin biosynthetic gene cluster from Legionella parisiensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Legioliulin
SMILES string: Copy to clipboard
Molecular formula: C19H14O3
Exact molecular mass: 291.101571 Da ([M+H]+)
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Thioesterase type:
Type I
Release / cyclization type:

Modular polyketide synthases:
Module 1
Module 2
KR stereochemistry: Unknown
Module 3
Module 4
Module 5
KR stereochemistry: Unknown
Module 6

Gene cluster description

legioliulin (BGC0000180). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KM222819, positions 4550-31415. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Gene expression correlated with compound production, Sequence-based prediction
Contact for this cluster:Helge B. Bode (Molecular Biotechnology, Institute for Molecular Bioscience, Goethe University Frankfurt, 60438 Frankfurt/Main, Germany)

Literature references

1. Ahrendt T et al. (2013) Biosynthesis of the natural fluorophore legioliulin from legionella. Chembiochem 14(12):1415-8. doi: 10.1002/cbic.201300373. Epub 2013