BGC0000180: legioliulin biosynthetic gene cluster from Legionella parisiensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 4,550 - 31,415 nt. (total: 26,866 nt).
This entry is originally from NCBI GenBank KM222819.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000180
Short description legioliulin biosynthetic gene cluster from Legionella parisiensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Trans-AT type I)
Loci
KM222819.1
4550 - 31415
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • legioliulin
Species Legionella parisiensis [taxonomy]
References
Chemical products information
legioliulin Evidence:
Copy SMILES
C19H14O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIU36103.1
 4550 - 19033 (+) LglD
    copy AA seq
    copy Nt seq
    • AIU36104.1
    		 19026 - 23054 (+) LglE
      copy AA seq
      copy Nt seq
      • AIU36105.1
      		 23271 - 24191 (-) LglF
        copy AA seq
        copy Nt seq
        • AIU36106.1
        		 24506 - 25210 (-) LglG
          copy AA seq
          copy Nt seq
          • AIU36107.1
          		 25387 - 26676 (-) LglH
            copy AA seq
            copy Nt seq
            • AIU36108.1
            		 26679 - 27743 (-) LglI
              copy AA seq
              copy Nt seq
              • AIU36109.1
              		 28311 - 29612 (-) LglJ
                copy AA seq
                copy Nt seq
                • AIU36110.1
                		 29694 - 31415 (-) PAL phenylalanine ammonia lyase
                • Precursor biosynthesis
                • Heterologous expression
                copy AA seq
                copy Nt seq
                Biosynthesis information

                Biosynthetic modules

                Name
                1
                Type
                pks-trans-at-starter
                Genes
                AIU36103.1
                Substrates
                Integrated Monomers
                Domains
                carrier (ACP)
                Name
                2
                Type
                pks-trans-at
                Genes
                AIU36103.1
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                Name
                3
                Type
                pks-trans-at
                Genes
                AIU36103.1
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, carrier (ACP)
                Name
                4
                Type
                pks-trans-at
                Genes
                AIU36103.1
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, carrier (ACP)
                Name
                5
                Type
                pks-trans-at
                Genes
                AIU36103.1
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, ketoreductase, carrier (ACP)
                Name
                6
                Type
                pks-trans-at
                Genes
                AIU36103.1
                Substrates
                Integrated Monomers
                Domains
                ketosynthase, dehydratase, carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: SCFYH7235HZBUM2XBV52IUHT)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
                Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                A domain glossary is available here, and an explanation of the visualisation is available here.
                Selected features only
                Show module domains
                Similar known gene clusters from MIBiG 4.0
                Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                Click on reference genes to show details of similarities to genes within the current region.
                Click on an accession to open that entry in the MiBIG database.