Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000181.1:
Cluster 1Other154840

BGC0000181, macrolactin biosynthetic gene cluster from Bacillus amyloliquefaciens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: macrolactin A
PubChem ID: 6451096
SMILES string: Copy to clipboard
Molecular formula: C24H34O5
Average molecular mass: 402.531 Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Other biosynthetic class:

Gene cluster description

macrolactin (BGC0000181). Gene Cluster 1. Biosynthetic class = Other. GenBank AJ634061. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Contact for this cluster:Rainer Borriss (Humboldt University Berlin)

Literature references

1. Chen XH et al. (2006) Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42. J Bacteriol 188(11):4024-36. doi: 10.1128/JB.00052-06.
2. Chen XH et al. (2007) Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42. Nat Biotechnol 25(9):1007-14. doi: 10.1038/nbt1325. Epub 2007 Aug 19.
3. Schneider K et al. (2007) Macrolactin is the polyketide biosynthesis product of the pks2 cluster of Bacillus amyloliquefaciens FZB42. J Nat Prod 70(9):1417-23. doi: 10.1021/np070070k. Epub 2007 Sep 11.