BGC0000181: macrolactin H biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 1 - 54,840 nt. (total: 54,840 nt).
This entry is originally from NCBI GenBank AJ634061.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000181
Short description macrolactin H biosynthetic gene cluster from Bacillus velezensis FZB42
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AJ634061.2
via Knock-out studies
Compounds
  • macrolactin H
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
macrolactin H Evidence:
Copy SMILES
C24H34O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG23963.1
  • pks2A
 1 - 2307 (+) malonyl CoA [acyl-carrier-protein] transacylase
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    • CAG23964.1
    • pks2B
    		 2329 - 14589 (+) polyketide synthase type I
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      • CAG23965.1
      • pks2C
      		 14589 - 19361 (+) polyketide synthase type I
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        • CAG23966.1
        • pks2D
        		 19379 - 28117 (+) polyketide synthase type I
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          • CAG23967.1
          • pks2E
          		 28110 - 35114 (+) polyketide synthase type I
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            • CAG23968.1
            • pks2F
            		 35129 - 40849 (+) polyketide synthase type I
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              • CAG23969.1
              • pks2G
              		 40846 - 48228 (+) polyketide synthase type I
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                • CAG23970.2
                • pks2H
                		 48267 - 52130 (+) polyketide synthase type I
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                  • CAJ57404.1
                  • pks2I
                  		 52127 - 53254 (+) pbp related beta-lactamase precursor
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                    • CAJ57405.1
                    • pdhA
                    		 53725 - 54840 (+) pyruvate dehydrogenase (E1 alpha subunit)
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      0
                      Type
                      pks-modular-starter
                      Genes
                      pks2A
                      Substrates
                      Integrated Monomers
                      Domains
                      acyltransferase
                      Name
                      1
                      Type
                      pks-trans-at
                      Genes
                      pks2B
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, carrier (ACP)
                      Name
                      2
                      Type
                      pks-trans-at
                      Genes
                      pks2B
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                      Name
                      3
                      Type
                      pks-trans-at
                      Genes
                      pks2B pks2C
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                      Name
                      4
                      Type
                      pks-trans-at
                      Genes
                      pks2C pks2D
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                      Name
                      5
                      Type
                      pks-trans-at
                      Genes
                      pks2D
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, carrier (ACP)
                      Name
                      6
                      Type
                      pks-trans-at
                      Genes
                      pks2D pks2E
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, carrier (ACP), carrier (ACP)
                      Name
                      7
                      Type
                      pks-trans-at
                      Genes
                      pks2E
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, carrier (ACP)
                      Name
                      8
                      Type
                      pks-trans-at
                      Genes
                      pks2E pks2F
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                      Name
                      9
                      Type
                      pks-trans-at
                      Genes
                      pks2F pks2G
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, carrier (ACP)
                      Name
                      10
                      Type
                      pks-trans-at
                      Genes
                      pks2G
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, ketoreductase, carrier (ACP), carrier (ACP)
                      Name
                      11
                      Type
                      pks-trans-at
                      Genes
                      pks2G pks2H
                      Substrates
                      Integrated Monomers
                      Domains
                      ketosynthase, dehydratase, ketoreductase, thioesterase, carrier (ACP), carrier (ACP)
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Merged cross-CDS PKS modules
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Corrected gene identifiers
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: FICEQDRJCNKWHHGNCRVDDP5D)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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