BGC0000182: pseudomonic acid A biosynthetic gene cluster from Pseudomonas fluorescens
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Location: 1 - 75,137 nt. (total: 75,137 nt).
This entry is originally from NCBI GenBank AF318063.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000182
Short description pseudomonic acid A biosynthetic gene cluster from Pseudomonas fluorescens
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
AF318063.3
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • pseudomonic acid A
Species Pseudomonas fluorescens [taxonomy]
References
Chemical products information
pseudomonic acid A Evidence:
Copy SMILES
C26H44O9
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFD33556.1
  • mupZ
 201 - 569 (+) MupZ
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    • AAK28503.1
    • mupA
    		 600 - 1709 (+) MupA
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      • AAM12909.2
      • mmpA
      		 1706 - 10243 (+) MmpA
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        • AAM12910.1
        • mupB
        		 10278 - 11183 (+) MupB
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          • AAM12911.1
          • mmpB
          		 11325 - 17555 (+) MmpB
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            • AAM12912.1
            • mmpC
            		 17629 - 20961 (+) MmpC
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              • AAM12913.2
              • mmpD
              		 20958 - 40526 (+) MmpD
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                • AAM12914.1
                • mupC
                		 40523 - 41818 (+) MupC
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                  • AAM12915.1
                  • macpA
                  		 41870 - 42175 (+) MacpA
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                    • AAM12916.1
                    • mupD
                    		 42216 - 42959 (+) MupD
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                      • AAM12917.1
                      • mupE
                      		 42983 - 44005 (+) MupE
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                        • AAM12918.1
                        • macpB
                        		 44062 - 44313 (+) MacpB
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                          • AAM12919.1
                          • mupF
                          		 44334 - 45344 (-) MupF
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                            • AAM12920.1
                            • macpC
                            		 45506 - 45742 (+) MacpC
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                              • AAM12921.1
                              • mupG
                              		 45729 - 46967 (+) MupG
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                                • AAM12922.1
                                • mupH
                                		 46964 - 48229 (+) MupH
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                                  • AAM12923.1
                                  • mupJ
                                  		 48226 - 48993 (+) MupJ
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                                    • AAM12924.1
                                    • mupK
                                    		 49047 - 49790 (+) MupK
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                                      • AAM12925.2
                                      • mmpE
                                      		 49802 - 53377 (+) MmpE
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                                        • AAM12926.1
                                        • mupL
                                        		 53423 - 54361 (+) MupL
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                                          • AAM12927.2
                                          • mupM
                                          		 54444 - 57536 (+) MupM
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                                            • AAM12928.2
                                            • mupN
                                            		 57597 - 58448 (+) MupN
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                                              • AAM12929.2
                                              • mupO
                                              		 58574 - 59938 (+) MupO
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                                                • AAM12930.2
                                                • mupP
                                                		 59935 - 60864 (+) MupP
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                                                  • AAM12931.1
                                                  • mupQ
                                                  		 60912 - 62267 (+) MupQ
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                                                    • AAM12932.1
                                                    • mupS
                                                    		 62264 - 63037 (+) MupS
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                                                      • AAM12933.1
                                                      • macpD
                                                      		 63031 - 63351 (+) MacpD
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                                                        • AAM12934.1
                                                        • mmpF
                                                        		 63348 - 65585 (+) MmpF
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                                                          • AAM12935.1
                                                          • macpE
                                                          		 65730 - 65972 (+) MacpE
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                                                            • AAM12936.1
                                                            • mupT
                                                            		 65995 - 66345 (+) MupT
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                                                              • AAM12937.1
                                                              • mupU
                                                              		 66415 - 67992 (+) MupU
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                                                                • AAM12938.1
                                                                • mupV
                                                                		 68027 - 70015 (+) MupV
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                                                                  • AAM12939.1
                                                                  • mupW
                                                                  		 70055 - 71446 (+) MupW
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                                                                    • AAK28504.1
                                                                    • mupR
                                                                    		 71638 - 72342 (+) MupR
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                                                                      • AAM12940.1
                                                                      • mupX
                                                                      		 72380 - 73918 (+) MupX
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                                                                        • AAK28505.1
                                                                        • mupI
                                                                        		 73911 - 74486 (-) MupI
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                                                                          Biosynthesis information

                                                                          Biosynthetic modules

                                                                          Name
                                                                          1
                                                                          Type
                                                                          pks-trans-at
                                                                          Genes
                                                                          mmpD
                                                                          Substrates
                                                                          Integrated Monomers
                                                                          Domains
                                                                          ketosynthase, dehydratase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                                                                          Name
                                                                          2
                                                                          Type
                                                                          pks-trans-at
                                                                          Genes
                                                                          mmpD
                                                                          Substrates
                                                                          Integrated Monomers
                                                                          Domains
                                                                          ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                                                          Name
                                                                          3
                                                                          Type
                                                                          pks-trans-at
                                                                          Genes
                                                                          mmpD
                                                                          Substrates
                                                                          Integrated Monomers
                                                                          Domains
                                                                          ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                                                                          Name
                                                                          4
                                                                          Type
                                                                          pks-trans-at
                                                                          Genes
                                                                          mmpD
                                                                          Substrates
                                                                          Integrated Monomers
                                                                          Domains
                                                                          ketosynthase, ketoreductase, carrier (ACP)
                                                                          Name
                                                                          5
                                                                          Type
                                                                          pks-trans-at
                                                                          Genes
                                                                          mmpA
                                                                          Substrates
                                                                          Integrated Monomers
                                                                          Domains
                                                                          ketosynthase, carrier (ACP)
                                                                          Name
                                                                          6
                                                                          Type
                                                                          pks-trans-at
                                                                          Genes
                                                                          mmpA
                                                                          Substrates
                                                                          Integrated Monomers
                                                                          Domains
                                                                          ketosynthase, ketoreductase, carrier (ACP)
                                                                          Name
                                                                          7
                                                                          Type
                                                                          pks-trans-at
                                                                          Genes
                                                                          mmpA
                                                                          Substrates
                                                                          Integrated Monomers
                                                                          Domains
                                                                          ketosynthase, carrier (ACP), carrier (ACP)
                                                                          Name
                                                                          8
                                                                          Type
                                                                          pks-trans-at
                                                                          Genes
                                                                          mmpB
                                                                          Substrates
                                                                          Integrated Monomers
                                                                          Domains
                                                                          ketosynthase, dehydratase, ketoreductase, carrier (ACP), carrier (ACP), carrier (ACP)
                                                                          Annotation changelog

                                                                          Entry version: 4

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-10-07
                                                                          Update chemical activity to schema version 2.11
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Removed entry error in polyketide synthase gene list
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2022-09-15
                                                                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2022-09-15
                                                                          Sorted modules by module number
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2022-09-15
                                                                          Fix trans_at gene ID
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2019-10-16
                                                                          Updated compound(s) information (NPAtlas curation)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2015-06-12
                                                                          Submitted
                                                                          • (ID: E74IDV7HCE4GDGQ2TWFM7I3H)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          Detailed domain annotation
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