BGC0000184: sorangicin A biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 148,058 nt. (total: 148,058 nt).
This entry is originally from NCBI GenBank HM584908.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000184
Short description sorangicin A biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Trans-AT type I)
Loci
HM584908.1
via Knock-out studies
Compounds
  • sorangicin A
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
sorangicin A Evidence:
Copy SMILES
C47H66O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADN68495.1
 23290 - 25626 (+) hypothetical protein
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    • ADN68496.1
    		 25632 - 27284 (+) hypothetical protein
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      • ADN68485.1
      • sorJ
      		 27367 - 28788 (-) SorJ
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        • ADN68486.1
        • sorK
        		 28969 - 30195 (-) SorK
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          • ADN68487.1
          • sorL
          		 30321 - 32447 (-) SorL
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            • ADN68497.1
            • sorM
            		 32731 - 36039 (-) SorM
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              • ADN68488.1
              • sorN
              		 36071 - 37480 (-) enoyl reductase
              • Scaffold biosynthesis
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              • ADN68489.1
              • sorO
              		 38018 - 39889 (+) tandem acyl transferase and enoyl reductase
              • Activation / processing
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              • ADN68490.1
              • sorP
              		 40160 - 41686 (+) SorP
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                • ADN68491.1
                • sorQ
                		 41933 - 43918 (+) SorQ
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                  • ADN68476.1
                  • sorA
                  		 44097 - 68231 (+) sorA
                  • Scaffold biosynthesis
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                  • ADN68477.1
                  • sorB
                  		 68228 - 83098 (+) SorB
                  • Scaffold biosynthesis
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                  • ADN68478.1
                  • sorC
                  		 83100 - 88016 (+) SorC
                  • Scaffold biosynthesis
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                  • ADN68479.1
                  • sorD
                  		 88020 - 97325 (+) SorD
                  • Scaffold biosynthesis
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                  • ADN68480.1
                  • sorE
                  		 97325 - 112942 (+) SorE
                  • Scaffold biosynthesis
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                  • ADN68481.1
                  • sorF
                  		 113013 - 114287 (+) SorF
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                    • ADN68482.1
                    • sorG
                    		 114338 - 122377 (+) sorG
                    • Scaffold biosynthesis
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                    • ADN68483.1
                    • sorH
                    		 121857 - 133514 (+) sorH
                    • Scaffold biosynthesis
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                    • ADN68484.1
                    • sorI
                    		 133608 - 141434 (+) sorI
                    • Scaffold biosynthesis
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                    • ADN68492.1
                    • sorR
                    		 141465 - 142616 (+) SorR
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                      • ADN68493.1
                      • sorS
                      		 142667 - 143881 (+) SorS
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                        • ADN68494.1
                        • sorT
                        		 144202 - 145995 (+) SorT
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                          • ADN68498.1
                          • sorU
                          		 146166 - 147548 (+) SorU
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            1
                            Type
                            pks-trans-at
                            Genes
                            sorA
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                            Name
                            2
                            Type
                            pks-trans-at
                            Genes
                            sorA
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, carrier (ACP)
                            Name
                            3
                            Type
                            pks-trans-at
                            Genes
                            sorA
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
                            Name
                            4
                            Type
                            pks-trans-at
                            Genes
                            sorA
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, carrier (ACP)
                            Name
                            5
                            Type
                            pks-trans-at
                            Genes
                            sorA
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, carrier (ACP)
                            Name
                            6
                            Type
                            pks-trans-at
                            Genes
                            sorA
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, carrier (ACP)
                            Name
                            7
                            Type
                            pks-trans-at
                            Genes
                            sorA sorB
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, carrier (ACP)
                            Name
                            8
                            Type
                            pks-trans-at
                            Genes
                            sorB
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, carrier (ACP)
                            Name
                            9
                            Type
                            pks-trans-at
                            Genes
                            sorB
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, carrier (ACP)
                            Name
                            10
                            Type
                            pks-trans-at
                            Genes
                            sorB
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                            Name
                            11
                            Type
                            pks-trans-at
                            Genes
                            sorB sorC
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, carrier (ACP)
                            Name
                            12
                            Type
                            pks-trans-at
                            Genes
                            sorC sorD
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                            Name
                            13
                            Type
                            pks-trans-at
                            Genes
                            sorD
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, carrier (ACP)
                            Name
                            14
                            Type
                            pks-trans-at
                            Genes
                            sorD sorE
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                            Name
                            15
                            Type
                            pks-trans-at
                            Genes
                            sorE
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                            Name
                            16
                            Type
                            pks-trans-at
                            Genes
                            sorE
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                            Name
                            17
                            Type
                            pks-trans-at
                            Genes
                            sorE sorG
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
                            Name
                            18
                            Type
                            pks-trans-at
                            Genes
                            sorG
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, carrier (ACP)
                            Name
                            19
                            Type
                            pks-trans-at
                            Genes
                            sorG sorH
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                            Name
                            20
                            Type
                            pks-trans-at
                            Genes
                            sorH
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                            Name
                            21
                            Type
                            pks-trans-at
                            Genes
                            sorH
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, carrier (ACP)
                            Name
                            22
                            Type
                            pks-trans-at
                            Genes
                            sorH sorI
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, carrier (ACP)
                            Name
                            23
                            Type
                            pks-trans-at
                            Genes
                            sorI
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
                            Annotation changelog

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Merged cross-CDS PKS modules
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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