BGC0000184: sorangicin A biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 148,058 nt. (total: 148,058 nt).
This entry is originally from NCBI GenBank HM584908.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000184
Short description sorangicin A biosynthetic gene cluster from Sorangium cellulosum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: HM584908.1
Compounds
  • sorangicin A
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
sorangicin A
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C47H66O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADN68495.1
 23290 - 25626 (+) hypothetical protein
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  • ADN68496.1
 25632 - 27284 (+) hypothetical protein
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  • ADN68485.1
  • sorJ
 27367 - 28788 (-) SorJ
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  • ADN68486.1
  • sorK
 28969 - 30195 (-) SorK
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  • ADN68487.1
  • sorL
 30321 - 32447 (-) SorL
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  • ADN68497.1
  • sorM
 32731 - 36039 (-) SorM
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  • ADN68488.1
  • sorN
 36071 - 37480 (-) enoyl reductase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68489.1
  • sorO
 38018 - 39889 (+) tandem acyl transferase and enoyl reductase
  • Activation / processing
Sequence-based prediction
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  • ADN68490.1
  • sorP
 40160 - 41686 (+) SorP
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  • ADN68491.1
  • sorQ
 41933 - 43918 (+) SorQ
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  • ADN68476.1
  • sorA
 44097 - 68231 (+) sorA
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68477.1
  • sorB
 68228 - 83098 (+) SorB
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68478.1
  • sorC
 83100 - 88016 (+) SorC
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68479.1
  • sorD
 88020 - 97325 (+) SorD
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68480.1
  • sorE
 97325 - 112942 (+) SorE
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68481.1
  • sorF
 113013 - 114287 (+) SorF
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  • ADN68482.1
  • sorG
 114338 - 122377 (+) sorG
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68483.1
  • sorH
 121857 - 133514 (+) sorH
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68484.1
  • sorI
 133608 - 141434 (+) sorI
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADN68492.1
  • sorR
 141465 - 142616 (+) SorR
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  • ADN68493.1
  • sorS
 142667 - 143881 (+) SorS
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  • ADN68494.1
  • sorT
 144202 - 145995 (+) SorT
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  • ADN68498.1
  • sorU
 146166 - 147548 (+) SorU
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
sorC
+
sorD
+
sorG
+
sorH
+
sorI
+
sorA
+
sorE
+
sorB
+
sorO 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: sorO
Module 1
Genes: sorA
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Genes: sorA
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 3
Genes: sorA
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 4
Genes: sorA
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Genes: sorA
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: sorA
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: sorA, sorB
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 8
Genes: sorB
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 9
Genes: sorB
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 10
Genes: sorB
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Genes: sorB, sorC
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 12
Genes: sorC, sorD
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 13
Genes: sorD
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 14
Genes: sorD, sorE
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 15
Genes: sorE
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 16
Genes: sorE
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 17
Genes: sorE, sorG
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 18
Genes: sorG
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 19
Genes: sorG, sorH
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 20
Genes: sorH
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 21
Genes: sorH
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 22
Genes: sorH, sorI
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 23
Genes: sorI
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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