Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000184.1:
Cluster 1Polyketide1148058

BGC0000184, sorangicin biosynthetic gene cluster from Sorangium cellulosum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Sorangicin A
SMILES string: Copy to clipboard
Molecular formula: C47H66O11
Exact molecular mass: 807.4678 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Malonyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
ADN68489.1
Thioesterase type:
None
Release / cyclization type:
Unknown

Modular polyketide synthases:
sorA (ADN68476.1)
Module 1
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 2
AT specificity: None
Evidence for specificity: Unknown
Module 3
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation
Module 4
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 5
AT specificity: None
Evidence for specificity: Unknown
Module 6
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 7
AT specificity: None
Evidence for specificity: Unknown

sorB (ADN68477.1)
Module 7
AT specificity: None
Evidence for specificity: Unknown
Module 8
AT specificity: None
Evidence for specificity: Unknown
Module 9
AT specificity: None
Evidence for specificity: Unknown
Module 10
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 11
AT specificity: None
Evidence for specificity: Unknown

sorC (ADN68478.1)
Module 11
AT specificity: None
Evidence for specificity: Unknown
Module 12
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group

sorD (ADN68479.1)
Module 12
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 13
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 14
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group

sorE (ADN68480.1)
Module 14
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 15
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: B-group
Module 16
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 17
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group

sorG (ADN68482.1)
Module 17
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation
Module 18
AT specificity: None
Evidence for specificity: Unknown
Module 19
AT specificity: None
Evidence for specificity: Unknown

sorH (ADN68483.1)
Module 19
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 20
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 21
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 22
AT specificity: None
Evidence for specificity: Unknown

sorI (ADN68484.1)
Module 22
AT specificity: None
Evidence for specificity: Unknown
Module 23
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group

Gene cluster description

sorangicin (BGC0000184). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank HM584908, positions 23952-148058. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Irschik H et al. (2010) Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by trans-AT PKS. Chembiochem 11(13):1840-9. doi: 10.1002/cbic.201000313.