BGC0000186: thailandamide biosynthetic gene cluster from Burkholderia thailandensis E264
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Location: 1,950,416 - 2,036,975 nt. (total: 86,560 nt).
This entry is originally from NCBI GenBank CP000085.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000186
Short description thailandamide biosynthetic gene cluster from Burkholderia thailandensis E264
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Polyene)
Loci NCBI GenBank: CP000085.1
Compounds
  • thailandamide
  • thailandamide lactone
Species Burkholderia thailandensis E264 [taxonomy]
References
Chemical products information
thailandamide
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C43H59N1O8
Chemical database entries
NPAtlas
thailandamide lactone
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C43H55N1O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTH_II1663
  • ABC36202.1
 1950416 - 1953928 (-) pyruvate ferredoxin/flavodoxin oxidoreductase family protein
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  • BTH_II1664
  • ABC34599.1
 1953925 - 1960173 (-) polyketide synthase, putative
  • Scaffold biosynthesis
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  • BTH_II1665
  • ABC33986.1
 1960098 - 1974047 (-) polyketide synthase, putative
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  • BTH_II1666
  • ABC34675.1
 1973189 - 1989889 (-) polyketide synthase, putative
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  • BTH_II1667
  • ABC34176.1
 1989915 - 1995620 (-) polyketide synthase, putative
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  • BTH_II1668
  • ABC35867.1
 1995632 - 1996378 (-) polyketide biosynthesis enoyl-CoA hydratase
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  • BTH_II1669
  • ABC35267.1
 1996375 - 1997175 (-) polyketide biosynthesis enoyl-CoA hydratase
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  • BTH_II1670
  • ABC34601.1
 1997172 - 1998428 (-) polyketide biosynthesis protein
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  • BTH_II1671
  • ABC34518.1
 1998412 - 1999665 (-) polyketide beta-ketoacyl synthase, putative
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  • BTH_II1672
  • ABC35804.1
 1999658 - 1999906 (-) acyl carier protein-related protein
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  • BTH_II1673
  • ABC35522.1
 1999941 - 2011718 (-) thiotemplate mechanism natural product synthetase
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  • BTH_II1674
  • ABC34832.1
 2011510 - 2028396 (-) polyketide synthase
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  • BTH_II1675
  • ABC34740.1
 2028449 - 2031913 (-) trans acyltransferase (AT-AT-ER)
  • Scaffold biosynthesis
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  • BTH_II1676
  • ABC34917.1
 2031959 - 2032756 (-) 4-phosphopantetheinyl transferase family protein
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  • BTH_II1677
  • ABC35757.1
 2033299 - 2033553 (+) phenolpthiocerol synthesis type-i polyketide synthase ppsa
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  • BTH_II1678
  • ABC35295.1
 2033561 - 2034322 (-) Ser/Thr protein phosphatase family
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  • BTH_II1679
  • ABC35022.1
  • accA-2
 2034376 - 2035344 (-) acetyl-CoA carboxylase, carboxyl transferase, alpha subunit
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  • BTH_II1680
  • ABC34496.1
 2035673 - 2036224 (-) hypothetical protein
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  • BTH_II1681
  • ABC34138.1
 2036259 - 2036975 (-) autoinducer-binding transcriptional regulator, LuxR family, putative
  • Regulation
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Polyketide-specific information
Subclass Polyene
Cyclic? no
Polyketide-synthases
Genes Properties Modules
BTH_II1664
+
BTH_II1667
+
BTH_II1674
+
BTH_II1665
+
BTH_II1673
+
BTH_II1666 		Synthase subclass: Modular type I
Module 1
Genes: BTH_II1674
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Genes: BTH_II1674
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Genes: BTH_II1674
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module 5
Genes: BTH_II1673
Core domains: Ketosynthase, Ketoreductase, Dehydratase
KR-domain stereochemistry: L-OH
Module 6
Genes: BTH_II1673
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Beta-branching
Module 7
Genes: BTH_II1667
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 8
Genes: BTH_II1667
Core domains: Ketosynthase
Module 9
Genes: BTH_II1667
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 10
Genes: BTH_II1666
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 11
Genes: BTH_II1666
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Beta-branching
Module 12
Genes: BTH_II1665
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 13
Genes: BTH_II1665
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module 14
Genes: BTH_II1664
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
BTH_II1673
Module 4
Specificity: D-alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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