Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000186.1:
Cluster 1NRP / Polyketide186560

BGC0000186, thailandamide biosynthetic gene cluster from Burkholderia thailandensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: thailandamide A
SMILES string: Copy to clipboard
Molecular formula: C43H60O8N
Exact molecular mass: 716.4134 Da ([M-H]-)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
None

Nonribosomal peptide synthetases:
ABC35522.1
Module 4
A specificity: D-alanine
Evidence for specificity: Sequence-based prediction
Amino acid biosynthesis subcluster:
C domain subtype: LCL
Polyketide subclass:
Polyene (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
Type I
Release / cyclization type:
None

Modular polyketide synthases:
ABC34832.1
Module 1
KR stereochemistry: A-group
Module 2
KR stereochemistry: B-group
Module 3
KR stereochemistry: B-group
Scaffold-modifying domain: Methylation

ABC35522.1
Module 5
KR stereochemistry: B-group
Module 6
Scaffold-modifying domain: Beta-branching

ABC34176.1
Module 7
KR stereochemistry: A-group
Module 8
Module 9
KR stereochemistry: B-group

ABC34675.1
Module 10
KR stereochemistry: B-group
Module 11
Scaffold-modifying domain: Beta-branching

ABC33986.1
Module 12
KR stereochemistry: B-group
Module 13
KR stereochemistry: B-group
Scaffold-modifying domain: Methylation

thaQ (ABC34599.1)
Module 14
Scaffold-modifying domain: Methylation

Gene cluster description

thailandamide (BGC0000186). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP000085, positions 1950416-2036975. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Proven expression in natural host, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Keishi Ishida (Leipniz Institute for Natural Product Research and Infection Biology)

Literature references

1. Nguyen T et al. (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat Biotechnol 26(2):225-33. doi: 10.1038/nbt1379. Epub 2008 Jan 27.
2. Ishida K et al. (2010) Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J Am Chem Soc 132(40):13966-8. doi: 10.1021/ja105003g.
3. Ishida K et al. (2012) Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis. Angew Chem Int Ed Engl 51(22):5470-4. doi: 10.1002/anie.201200067.