BGC0000187: asukamycin biosynthetic gene cluster from Streptomyces nodosus subsp. asukaensis
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Location: 1 - 63,922 nt. (total: 63,922 nt).
This entry is originally from NCBI GenBank GQ926890.1.

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core biosynthetic genes
additional biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000187
Short description asukamycin biosynthetic gene cluster from Streptomyces nodosus subsp. asukaensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "3-amino-4-hydroxybenzoic acid is the precursor for 2-amino-4-hydroxy-5,6-epoxycyclohex-2-enone"
Biosynthetic class(es)
  • Polyketide (Polyene)
Loci NCBI GenBank: GQ926890.1
Compounds
  • asukamycin
Species Streptomyces nodosus subsp. asukaensis [taxonomy]
References
Chemical products information
asukamycin
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C31H34N2O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADI58659.1
 29 - 1096 (+) hypothetical protein
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  • ADI58660.1
 1341 - 1643 (+) hypothetical protein
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  • ADI58661.1
 1866 - 3689 (+) hypothetical protein
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  • ADI58662.1
 3689 - 4354 (+) hypothetical protein
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  • ADI58663.1
 4347 - 5102 (+) hypothetical protein
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  • ADI58664.1
 5099 - 5866 (+) hypothetical protein
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  • ADI58665.1
 5853 - 7118 (-) hypothetical protein
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  • ADI58666.1
 7370 - 7933 (+) hypothetical protein
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  • ADI58667.1
 8052 - 8630 (+) hypothetical protein
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  • ADI58668.1
 8737 - 9168 (+) hypothetical protein
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  • ADI58669.1
 9251 - 10393 (-) hypothetical protein
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  • ADI58670.1
 10390 - 10692 (-) hypothetical protein
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  • ADI58671.1
 10698 - 11426 (-) hypothetical protein
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  • ADI58672.1
 11463 - 13016 (-) hypothetical protein
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  • ADI58673.1
 13013 - 14686 (-) hypothetical protein
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  • ADI58674.1
 14761 - 16332 (-) hypothetical protein
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  • ADI58675.1
 16427 - 17881 (-) hypothetical protein
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  • ADI58676.1
 18185 - 19852 (-) hypothetical protein
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  • ADI58677.1
 19965 - 20771 (-) hypothetical protein
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  • ADI58678.1
 20849 - 21142 (+) hypothetical protein
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  • ADI58679.1
 21139 - 22389 (+) hypothetical protein
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  • ADI58680.1
 22419 - 23357 (+) hypothetical protein
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  • ADI58681.1
 23354 - 23872 (+) hypothetical protein
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  • ADI58682.1
 23921 - 24289 (-) hypothetical protein
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  • ADI58683.1
 24430 - 24885 (-) hypothetical protein
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  • ADI58684.1
 25156 - 25386 (+) hypothetical protein
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  • ADI58623.1
  • asuR4
 25411 - 25836 (-) Transcriptional regulation
  • Regulation
Sequence-based prediction
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  • ADI58624.1
  • asuR3
 25976 - 26899 (-) Transcriptional regulation
  • Regulation
Sequence-based prediction
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  • ADI58625.1
  • asuR2
 26960 - 27535 (-) Transcriptional regulation
  • Regulation
Sequence-based prediction
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  • ADI58626.1
  • asuR1
 27554 - 28204 (-) Transcriptional regulation
  • Regulation
Sequence-based prediction
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  • ADI58627.1
  • asuC1
 28309 - 28968 (-) Phosphopantetheinyl transferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADI58628.1
  • asuE1
 29329 - 30552 (+) Protoasukamycin 4-hydroxylase
  • Tailoring (Oxidation)
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  • ADI58629.1
  • asuB4
 30611 - 32614 (-) 2,4-DienoylCoA reductase
  • Precursor biosynthesis
Sequence-based prediction
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  • ADI58630.1
  • asuB3
 32658 - 33491 (-) 1-Cyclohexenylcarbonyl CoA reductase
  • Precursor biosynthesis
Sequence-based prediction
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  • ADI58631.1
  • AsuB2
 33488 - 34672 (-) Acyl-CoA dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • ADI58632.1
  • asuB1
 34669 - 37620 (-) 5-Enolpyruvylshikimate-3-phosphate synthase/CHC-CoA ligase
  • Precursor biosynthesis
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  • ADI58633.1
  • asuC5
 37663 - 37917 (-) Asukamycin KSIII associated ACP
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADI58634.1
  • asuC4
 37928 - 39013 (-) Asukamycin ketosynthase III
  • Scaffold biosynthesis
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  • ADI58635.1
  • asuC3
 39010 - 40026 (-) Asukamycin ketosynthase III
  • Scaffold biosynthesis
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  • ADI58636.1
  • AsuC2
 40108 - 40917 (-) Arylamine N-acyltransferase
  • Scaffold biosynthesis
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  • ADI58637.1
  • asuC6
 41274 - 41729 (+) Thioesterase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADI58638.1
  • asuE2
 41746 - 42303 (+) Flavin reducatse
  • Tailoring (Reduction)
Activity assay
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  • ADI58639.1
  • asuC7
 42365 - 43069 (+) Ketoreductase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADI58640.1
  • asuC10
 43147 - 43431 (-) Unknown
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  • ADI58641.1
  • asuC9
 43428 - 43880 (-) Acyl dehydratase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADI58642.1
  • asuC8
 43877 - 44335 (-) Acyl dehydratase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADI58643.1
  • asuA2
 44332 - 45747 (-) 3,4-AHBA carboxyl group adenylation
  • Activation / processing
Activity assay
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  • ADI58644.1
  • asuA1
 45867 - 46985 (-) 3,4-AHBA synthase
  • Precursor biosynthesis
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  • ADI58645.1
  • asuD1
 47448 - 49043 (+) Amide synthase
  • Precursor biosynthesis
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  • ADI58646.1
  • asuD2
 49040 - 50269 (+) 2-Oxoamine synthase
  • Precursor biosynthesis
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  • ADI58647.1
  • asuD3
 50506 - 51912 (+) 5-Aminolevulinate CoA ligase
  • Precursor biosynthesis
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  • ADI58648.1
  • asuE3
 51995 - 53110 (-) 4-Hydroxyprotoasukamycin epoxidase
  • Tailoring (Oxidation)
Activity assay
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  • ADI58649.1
  • asuC14
 53157 - 53879 (-) Ketosynthase I/II
  • Scaffold biosynthesis
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  • ADI58650.1
  • asuC13
 53935 - 55116 (-) Ketosynthase I/II
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADI58651.1
  • asuC12
 55118 - 55381 (-) 3,4-AHBA carrier protein
  • Activation / processing
Activity assay
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  • ADI58652.1
  • asuC11
 55378 - 55653 (-) KSI/II associated ACP
  • Scaffold biosynthesis
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  • ADI58653.1
  • asuA3
 55734 - 56570 (-) Condensation of L-aspartate-4-semialdehyde and dihydroxyacetone phosphate
  • Precursor biosynthesis
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  • ADI58654.1
  • asuC15
 56829 - 57611 (+) Type II thioesterase
  • Activation / processing
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  • ADI58655.1
  • asuM1
 57721 - 59259 (+) Asukamycin exporter
  • Transport
Sequence-based prediction
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  • ADI58657.1
  • asuR5
 59539 - 60303 (+) Transcriptional regulation
  • Regulation
Sequence-based prediction
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  • ADI58656.1
  • asuH1
 60425 - 61579 (+) Hypothetical
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  • ADI58658.1
  • asuR6
 61590 - 62432 (-) Transcriptional regulation
  • Regulation
Sequence-based prediction
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Polyketide-specific information
Subclass Polyene
Ketide length 6
Cyclic? no
Polyketide-synthases
Genes Properties Modules
asuC4
+
asuC13
+
asuC14
+
asuC3 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: VQJTWYI3STDVOHG36EUY4LM4, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added AMP-binding domain substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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