Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000187.1:
Cluster 1Polyketide163922

BGC0000187, asukamycin biosynthetic gene cluster from Streptomyces nodosus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: asukamycin
PubChem ID: 6441014
SMILES string: Copy to clipboard
Molecular formula: C31H34N2O7
Average molecular mass: 546.62 Da
Molecular activity: Antibacterial, Cytotoxic, Pigment

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Polyene (linear)
Polyketide synthase subclass:
Type II
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
ADI58634.1,ADI58635.1,ADI58649.1,ADI58650.1

Gene cluster description

asukamycin (BGC0000187). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank GQ926890. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Comments:3-amino-4-hydroxybenzoic acid is the precursor for 2-amino-4-hydroxy-5,6-epoxycyclohex-2-enone
Contact for this cluster:Zhe Rui (UC Berkeley)

Literature references

1. Rui Z et al. (2014) Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase. Proc Natl Acad Sci U S A 111(51):18237-42. doi: