BGC0000188: saxitoxin biosynthetic gene cluster from Cylindrospermopsis raciborskii T3
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Location: 1 - 37,606 nt. (total: 37,606 nt).
This entry is originally from NCBI GenBank DQ787200.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000188
Short description saxitoxin biosynthetic gene cluster from Cylindrospermopsis raciborskii T3
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Alkaloid (Purine)
Loci NCBI GenBank: DQ787200.1
Compounds
  • saxitoxin
  • neosaxitoxin
  • decarbamoylsaxitoxin
  • gonyautoxin 3
  • gonyautoxin 2
Species Cylindrospermopsis raciborskii T3 [taxonomy]
References
Chemical products information
saxitoxin [synonyms: stx, saxitoxin hydrate]
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C10H17N7O4
Chemical database entries
PubCHEM
ChEBI
ChEMBL
ChemSpider
neosaxitoxin [synonyms: neo, neostx]
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C10H17N7O5
Chemical database entries
PubCHEM
ChemSpider
decarbamoylsaxitoxin [synonyms: dcstx]
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C9H16N6O3
Chemical database entries
PubCHEM
ChemSpider
gonyautoxin 3 [synonyms: gtx 3, gtx iii]
(no structure information available)
Chemical database entries
ChemSpider
gonyautoxin 2 [synonyms: gtx ii]
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C10H17N7O8S1
Chemical database entries
PubCHEM
ChEBI
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABI75088.1
 1 - 1320 (+) alr5035-like protein
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  • ABI75089.1
  • sxtD
 1625 - 2383 (+) sterole desaturase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75090.1
 2621 - 3016 (-) InsB-like protein
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  • ABI75091.1
 2955 - 3314 (-) InsA-like protein
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  • ABI75092.1
  • sxtC
 3647 - 4000 (-) Unknown
  • Unknown
Sequence-based prediction
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  • ABI75093.1
  • sxtB
 4030 - 4986 (-) cytidine deaminase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75094.1
  • sxtA
 5047 - 8784 (-) polyketide synthase-related protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75095.1
  • sxtE
 9140 - 9526 (+) chaperone-like protein
  • Unknown
Sequence-based prediction
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  • ABI75096.1
  • sxtF
 9686 - 11101 (+) sodium-driven multidrug and toxic compound extrusion protein
  • Transport
Sequence-based prediction
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  • ABI75097.1
  • sxtG
 11112 - 12245 (+) amidinotransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75098.1
  • sxtH
 12314 - 13318 (+) phenylpropionate dioxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75099.1
  • sxtI
 13476 - 15314 (+) NodU/CmcH-related carbamoyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75100.1
  • sxtJ
 15318 - 15761 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • ABI75101.1
  • sxtK
 15761 - 15925 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • ABI75102.1
  • sxtL
 15937 - 17235 (+) GDSL-lipase
  • Unknown
Sequence-based prediction
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  • ABI75103.1
  • sxtM
 17323 - 18771 (+) sodium-driven multidrug and toxic compound extrusion protein
  • Transport
Sequence-based prediction
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  • ABI75104.1
  • sxtN
 19119 - 19949 (+) sulfotransferase
  • Tailoring (Sulfation)
Sequence-based prediction
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  • ABI75105.1
  • sxtX
 20238 - 21011 (-) cephalosporin hydroxylase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • ABI75106.1
  • sxtW
 21175 - 21501 (-) ferredoxin
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75107.1
  • sxtV
 21542 - 23194 (-) FAD-dependent succinate dehydrogenase/fumarate reductase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75108.1
  • sxtU
 23199 - 23948 (-) short-chain alcohol dehydrogenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75109.1
  • sxtT
 24091 - 25095 (-) phenylpropionate dioxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75110.1
  • sxtS
 25173 - 25898 (-) phytanoyl-CoA dioxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ABI75111.1
 25974 - 26549 (-) cyanophage S-PM2 protein CAF34141-like protein
  • Unknown
Sequence-based prediction
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  • ABI75112.1
  • sxtR
 26605 - 27381 (-) acyl-CoA N-acyltransferase
  • Unknown
Sequence-based prediction
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  • ABI75113.1
  • sxtQ
 27392 - 28168 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • ABI75114.1
  • sxtP
 28281 - 29507 (-) putative saxitoxin-binding protein
  • Unknown
Sequence-based prediction
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  • ABI75115.1
  • sxtO
 29667 - 30269 (-) adenylylsulfate kinase
  • Activation / processing
Sequence-based prediction
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  • ABI75116.1
 30612 - 31961 (-) transposase
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  • ABI75117.1
  • sxtY
 32612 - 33277 (-) phosphate uptake regulator
  • Regulation
Sequence-based prediction
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  • ABI75118.1
  • sxtZ
 33325 - 34677 (-) histidine kinase
  • Regulation
Sequence-based prediction
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  • ABI75119.1
 35029 - 35847 (-) transcriptional regulator OmpR family
  • Regulation
Sequence-based prediction
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  • ABI75120.1
 35972 - 36745 (-) HisA-related protein
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  • ABI75121.1
 37060 - 37455 (+) unknown
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: EI7LXM427LE4WIOQ5U54V3BB, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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