BGC0000188: saxitoxin biosynthetic gene cluster from Cylindrospermopsis raciborskii T3
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Location: 1 - 37,606 nt. (total: 37,606 nt).
This entry is originally from NCBI GenBank DQ787200.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000188
Short description saxitoxin biosynthetic gene cluster from Cylindrospermopsis raciborskii T3
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
DQ787200.1
via
Compounds
  • saxitoxin
  • neosaxitoxin
  • decarbamoylsaxitoxin
  • gonyautoxin 3
  • gonyautoxin 2
Species Cylindrospermopsis raciborskii T3 [taxonomy]
References
Chemical products information
saxitoxin Evidence:
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C10H17N7O4
Chemical database entries
PubCHEM
ChEBI
ChEMBL
ChemSpider
neosaxitoxin Evidence:
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C10H17N7O5
Chemical database entries
PubCHEM
ChemSpider
decarbamoylsaxitoxin Evidence:
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C9H16N6O3
Chemical database entries
PubCHEM
ChemSpider
gonyautoxin 3 Evidence:
(no structure information available)
Chemical database entries
ChemSpider
gonyautoxin 2 Evidence:
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C10H17N7O8S1
Chemical database entries
PubCHEM
ChEBI
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABI75088.1
 1 - 1320 (+) alr5035-like protein
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    • ABI75089.1
    • sxtD
    		 1625 - 2383 (+) sterole desaturase
    • Scaffold biosynthesis
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    • ABI75090.1
    		 2621 - 3016 (-) InsB-like protein
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      • ABI75091.1
      		 2955 - 3314 (-) InsA-like protein
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        • ABI75092.1
        • sxtC
        		 3647 - 4000 (-) Unknown
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          • ABI75093.1
          • sxtB
          		 4030 - 4986 (-) cytidine deaminase
          • Scaffold biosynthesis
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          • ABI75094.1
          • sxtA
          		 5047 - 8784 (-) polyketide synthase-related protein
          • Scaffold biosynthesis
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          • ABI75095.1
          • sxtE
          		 9140 - 9526 (+) chaperone-like protein
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            • ABI75096.1
            • sxtF
            		 9686 - 11101 (+) sodium-driven multidrug and toxic compound extrusion protein
            • Transport
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            • ABI75097.1
            • sxtG
            		 11112 - 12245 (+) amidinotransferase
            • Scaffold biosynthesis
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            • ABI75098.1
            • sxtH
            		 12314 - 13318 (+) phenylpropionate dioxygenase
            • Scaffold biosynthesis
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            • ABI75099.1
            • sxtI
            		 13476 - 15314 (+) NodU/CmcH-related carbamoyltransferase
            • Scaffold biosynthesis
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            • ABI75100.1
            • sxtJ
            		 15318 - 15761 (+) hypothetical protein
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              • ABI75101.1
              • sxtK
              		 15761 - 15925 (+) hypothetical protein
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                • ABI75102.1
                • sxtL
                		 15937 - 17235 (+) GDSL-lipase
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                  • ABI75103.1
                  • sxtM
                  		 17323 - 18771 (+) sodium-driven multidrug and toxic compound extrusion protein
                  • Transport
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                  • ABI75104.1
                  • sxtN
                  		 19119 - 19949 (+) sulfotransferase
                  • Tailoring
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                  • ABI75105.1
                  • sxtX
                  		 20238 - 21011 (-) cephalosporin hydroxylase
                  • Tailoring
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                  • ABI75106.1
                  • sxtW
                  		 21175 - 21501 (-) ferredoxin
                  • Scaffold biosynthesis
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                  • ABI75107.1
                  • sxtV
                  		 21542 - 23194 (-) FAD-dependent succinate dehydrogenase/fumarate reductase
                  • Scaffold biosynthesis
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                  • ABI75108.1
                  • sxtU
                  		 23199 - 23948 (-) short-chain alcohol dehydrogenase
                  • Scaffold biosynthesis
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                  • ABI75109.1
                  • sxtT
                  		 24091 - 25095 (-) phenylpropionate dioxygenase
                  • Scaffold biosynthesis
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                  • ABI75110.1
                  • sxtS
                  		 25173 - 25898 (-) phytanoyl-CoA dioxygenase
                  • Scaffold biosynthesis
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                  • ABI75111.1
                  		 25974 - 26549 (-) cyanophage S-PM2 protein CAF34141-like protein
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                    • ABI75112.1
                    • sxtR
                    		 26605 - 27381 (-) acyl-CoA N-acyltransferase
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                      • ABI75113.1
                      • sxtQ
                      		 27392 - 28168 (-) hypothetical protein
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                        • ABI75114.1
                        • sxtP
                        		 28281 - 29507 (-) putative saxitoxin-binding protein
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                          • ABI75115.1
                          • sxtO
                          		 29667 - 30269 (-) adenylylsulfate kinase
                          • Activation / processing
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                          • ABI75116.1
                          		 30612 - 31961 (-) transposase
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                            • ABI75117.1
                            • sxtY
                            		 32612 - 33277 (-) phosphate uptake regulator
                            • Regulation
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                            • ABI75118.1
                            • sxtZ
                            		 33325 - 34677 (-) histidine kinase
                            • Regulation
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                            • ABI75119.1
                            		 35029 - 35847 (-) transcriptional regulator OmpR family
                            • Regulation
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                            • ABI75120.1
                            		 35972 - 36745 (-) HisA-related protein
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                              • ABI75121.1
                              		 37060 - 37455 (+) unknown
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                                Biosynthesis information
                                Annotation changelog

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Cleaned up synonym list
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Updated bioactivity data
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: EI7LXM427LE4WIOQ5U54V3BB)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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