Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000188.1:
Cluster 1Alkaloid137606

BGC0000188, saxitoxin biosynthetic gene cluster from Cylindrospermopsis raciborskii. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Saxitoxin
PubChem ID: 37165
ChEBI ID: 34970
ChEMBL ID: 501134
ChemSpider ID: 34106
SMILES string: Copy to clipboard
Molecular formula: C10H17N7O4
Average molecular mass: 299.291 Da
Molecular activity: Other
Molecular target: Voltage-gated sodium channels of nerve cells

Class-specific details

Biosynthetic class(es):
Alkaloid
Alkaloid subclass:
Purine

Gene cluster description

saxitoxin (BGC0000188). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank DQ787200. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Brett Neilan (The University of New South Wales)

Literature references

1. Kellmann R et al. (2008) Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria. Appl Environ Microbiol 74(13):4044-53. doi: 10.1128/AEM.00353-08. Epub
2. Soto-Liebe K et al. (2010) Reassessment of the toxin profile of Cylindrospermopsis raciborskii T3 and function of putative sulfotransferases in synthesis of sulfated and sulfonated PSP toxins. Toxicon 56(8):1350-61. doi: 10.1016/j.toxicon.2010.07.022. Epub 2010